DC41887Cortagine
Cortagine is a specific corticotropin-releasing factor receptor subtype 1 (CRF1) agonist with an IC50 of 2.6 nM for rCRF1. Cortagine is an anxiolytic and antidepressive drug in the mouse model.
View activity & pricesDC Chemicals · Research reagentsDC41887 
DC12378
DC26189
DC9627
DC12282
DC12298
DC58000
DC21852
DC11026
DC48424
DC50025
DC2052
DC22995
DC23396
DC33464
DC23913
DC12047
DC9296
DC23954
DC60528
DC21839
DC9154
DC47616
DC3172
DC20987
DC28740
DC23122
DC7238
DC9206
DC70380
DC11136
DC2084
DC12478
DC8032
DC5073
DC7283
DC72750
DC21321
DC60068
DC28545
DC39823
DC12636
DC7953
DC60128
DC50166
DC20900
DC60180
DC12292
Small Molecule Research Tools
2816 products · Page 37 of 59
Browse 372 research categories
DC41887DC12378Itacitinib(INCB039110)
Itacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis.
View activity & pricesDC26189Denifanstat (TVB-2640)
TVB-2640(FASN-IN-2) is a Fatty Acid Synthase (FASN) inhibitor extracted from patent WO2012122391A1, compound 152, has an IC50 of 0.052 μM and an EC50 of 0.072 μM[1].
View activity & pricesDC9627AZM475271
AZM475271 is a potent and selective Src kinase inhibitor with IC50 of 5 nM; no inhibitory activity on Flt3, KDR, Tie-2.
View activity & pricesDC12282Semaglutide (sodium salt)
Semaglutide, a long-acting GLP-1 analogue, is a glucagon-like peptide-1 (GLP-1) receptor agonist that can be used in the treatment of type 2 diabetes.
View activity & pricesDC12298Octreotide acetate (SMS 201-995 (acetate))
Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.
View activity & pricesDC580004'-fluorouridine (4'-FlU, EIDD-2749)
4'-fluorouridine (4'-FlU, EIDD-2749) is a ribonucleoside analog that inhibits respiratory syncytial virus (RSV), related RNA viruses, and SARS-CoV-2 with high selectivity index (EC50/CC50 of ≥1877) in cells and human…
View activity & pricesDC21852ZINC02092166
ZINC02092166 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 1.7 and 7.0 uM in AlphaScreen and FP assay (wild-type β-catenin), respectively;…
View activity & pricesDC11026Tecovirimat
Tecovirimat(ST-246) is an orally bioavailable antipoxvirus compound; potent and selective active against multiple orthopoxviruses with EC50 about 10 nM.
View activity & pricesDC48424Enbezotinib
Enbezotinib, an inhibitor of RET, can inhibit the RET autophosphorylation. Enbezotinib can be used for the research of cancer[1].
View activity & pricesDC50025Deruxtecan
Deruxtecan, a topoisomerase I inhibitor, is an exatecan derivative (DX-8951 derivative) with a cleavable pepetide linker and a maleimide group. The maleimide group in Deruxtecan can react with antibody to form…
View activity & pricesDC2052ML-7 Hydrochloride
ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK (IC50=300 nM) and TRPC6 channel (IC50>10 μM).
View activity & pricesDC22995IRES-J007
IRES-J007 ia an improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to…
View activity & pricesDC23396TTK21(CBP-p300 activator TTK21)
TTK21 (CBP-p300 activator TTK21) is a small molecule activator of CBP/p300 histone acetyltransferase activity with a maximal effect at a concentration of 275 uM; induces acetylation of histones H3 and H4 in vitro but…
View activity & pricesDC33464GSK 2830371
GSK 2830371 is a highly selective Wip1 phosphatase inhibitor with IC50 of 6 nM.
View activity & pricesDC23913Chlorotoxin
Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity. Chlorotoxin is a chloride channel blocker.
View activity & pricesDC12047Sarolaner(PF-6450567)
Sarolaner (PF-6450567) is an orally active, broad-spectrum ectoparasiticide, has efficacy against fleas and ticks on dogs, with LC80 of 0.3 μg/mL against C. felis and an LC100 of 0.003 μg/mL against O. turicata[1].
View activity & pricesDC9296A-1331852
A-1331852 is an orally available BCL-XL selective inhibitor with a Ki of less than 10 pM.
View activity & pricesDC23954ISO-1
ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.
View activity & pricesDC60528DNL343
DNL343 is a potent, selective, and brain-penetrant eukaryotic translation initiation factor 2B (eIF2B) activator with ATF4 IC50 of 9.8 nM.
View activity & pricesDC21839Yhhu-3792
Yhhu-3792 is a novel small molecule that enhances the self-renewal capability of neural stem cells (NSCs) in vitro and in vivo via activating the Notch signaling pathway; activates Notch signaling pathway and promotes…
View activity & pricesDC9154Cetirizine 2HCl
Cetirizine 2Hcl, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and…
View activity & pricesDC47616EPZ-719
EPZ-719 is a novel and potent SETD2 inhibitor ( IC50 = 0.005 μM) with a high selectivity over other histone methyltransferases.
View activity & pricesDC3172Mirabegron
Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
View activity & pricesDC20987Cedazuridine
Cedazuridine (E7727) is a Cytidine Deaminase (CDA) inhibitor with an IC50 value of 0.4 μM[1].
View activity & pricesDC28740ERAP1-IN-1
ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates.
View activity & pricesDC23122DiZPK
DiZPK is a photocrosslinker for identifying direct protein-protein interactions in living prokaryotic and eukaryotic cells.
View activity & pricesDC7238Gedatolisib(PKI-587)
Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively. PKI-587 is equally effective in both complexes of mTOR, mTORC1 and mTORC2.
View activity & pricesDC9206Cysteamine bitartrate
Cysteamine bitartrate is available from DC Chemicals for laboratory research. Contact us for application-specific product information.
View activity & pricesDC70380EGPI-1
EGPI-1 is a potent small molecule that inhibits the translation initiation factors eIF4E/eIF4G interaction.EGPI-1 has potent antiproliferative and proapoptotic activity in multiple myeloma cells, Jurkat cells, and A549…
View activity & pricesDC11136JAK2 inhibitor G5-7
JAK2 inhibitor G5-7 is a small molecule, allosteric JAK2 inhibitor that selectively inhibits JAK2-mediated phosphorylation and activation of EGFR and STAT3 by binding to JAK2; demonstrates inhibitor of U87MG/EGFR and…
View activity & pricesDC2084Necrostatin-1
Necrostatin-1 is a potent, selective and cell-permeable necroptosis inhibitor with an EC50 of 490 nM in Jurkat cells. It acts by inhibiting the death domain kinase RIP (RIP1) in the necroptosis pathway.
View activity & pricesDC12478NSC 260594
NSC260594 (NSC 260594) is a specific inhibitor of HIV-1 RNA packaging, which involves preventing the interaction of Gag with SL3 by stabilizing this small RNA stem-loop which then leads to stabilization of the global…
View activity & pricesDC8032Solithromycin
Solithromycin is a novel fluoroketolide with improved antimicrobial effectiveness.Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis. The mean 50% inhibitory concentrations…
View activity & pricesDC5073TAK-875(Fasiglifam)
Fasiglifam (TAK-875) is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 72 nM.
View activity & pricesDC7283SCH-772984
SCH772984 potently inhibits ERK1 and ERK2 activity with IC50s of 4 and 1 nM, respectively.
View activity & pricesDC72750GNE-9822
GNE-9822 is a potent, orally active and selective ITK inhibitor with a Ki value of 0.7 nM. GNE-9822 has good ADME properties. GNE-9822 can be used in research of asthma.
View activity & pricesDC21321ML349
ML349 is a potent and specific acyl protein thioesterase 2 (APT-2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM.
View activity & pricesDC60068PD-123319 free base
PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
View activity & pricesDC28545N-Desmethyltamoxifen hydrochloride
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen.…
View activity & pricesDC39823Diphenylterazine (DTZ)
Diphenylterazine is a bioluminescence agent.
View activity & pricesDC12636Apararenone
Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.
View activity & pricesDC7953GNE-493
GNE-493 is a potent, selective, and orally available dual pan-PI3-kinase/mTOR inhibitor with IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.
View activity & pricesDC60128Benitrobenrazide
Benitrobenrazide is a novel selective hexokinase 2 (HK2) inhibitor, blocking cancer cells growth by targeting glycolysis.
View activity & pricesDC50166Bim-IN-1
Bim-IN-1 is a potent Bim expression inhibitor. Bim-IN-1 reduces Bim expression levels and has little inhibitory effect upon protein kinase A activity and minimal toxicity.
View activity & pricesDC20900ML382
ML382 is a potent, selective, positive allosteric modulator of Mas-related G protein-coupled receptor X1 (MrgprX1) with EC50 of 190 nM in cell based Ca2+ imaging assay; displays >100-fold selectivity versus MrgX2;…
View activity & pricesDC60180BUN79398
BUN79398(MRGPRX1 agonist 1) is a highly potent agonist of MRGPRX1 (Mas-related G-protein-coupled receptor X1), with an EC50 of 50 nM, and is inactive on MRGPRC11. Analgesic effect[1].
View activity & pricesDC12292Cl-amidine hydrochloride
In Vitro Cl-amidine is a peptidylarginine deminase (PAD) inhibitor, with an IC50 of 5.9±0.3 μM for PAD4 and Cl-amidine is a bioavailable haloacetamidine-based compound that inhibits all the active PAD isozymes with…
View activity & prices