DC12287delta-Valerobetaine
Delta-valerobetaine is a microbiome-derived metabolite used to investigate mitochondrial fatty-acid oxidation and diet-dependent obesity.
View activity & pricesDC Chemicals · Research reagentsDC12287 
DC12312
DC12391
DC12396
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DC12482
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DC53045
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Small Molecule Research Tools
2816 products · Page 2 of 59
Browse 372 research categories
DC12287DC12312OTX008 (Calixarene 0118; PTX008)
OTX008 (Calixarene 0118, PTX008) is a galectin-1 inhibitor used in tumor-cell signaling and viability research.
View activity & pricesDC12391BL-AD008
BL-AD008 is an AMPK/ZIPK-directed activator investigated in cervical-cancer apoptosis research.
View activity & pricesDC12396CR4056
CR4056 is an imidazoline-I2 ligand for pain signaling and monoaminergic research.
View activity & pricesDC12438G6PD activator AG1
AG1 is a small-molecule G6PD activator for enzyme oligomerization, NADPH metabolism and redox research.
View activity & pricesDC12482PTC299
PTC299 (Emvododstat) is a DHODH inhibitor for pyrimidine metabolism and hematological-cancer research.
View activity & pricesDC53131Sulfopin
Sulfopin is a covalent PIN1 inhibitor used to study prolyl-isomerase signaling and MYC-driven cancer biology.
View activity & pricesDC53045STM2457
STM2457 is a catalytic METTL3 inhibitor for RNA methylation, leukemia-cell differentiation and cancer research.
View activity & pricesDC11886Adavivint
Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.
View activity & pricesDC5090WZ4002
WZ4002 is a mutant selective EGFR inhibitor with IC50s of 2, 8, 3 and 2 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746_A750 and EGFRE746_A750/T790M, respectively.
View activity & pricesDC7146GW788388
GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, and also inhibits TGF-β type II receptor and activin type II receptor activities, without inhibiting BMP type II receptor.
View activity & pricesDC6308Sofosbuvir（PSI7977，GS-7977）
Sofosbuvir (PSI-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM.
View activity & pricesDC8042CB-839(Telaglenastat)
Telaglenastat (CB-839) is a potent and selective inhibitor of glutaminase with an IC50 of less than 50 nM.
View activity & pricesDC7060AZD1152
AZD1152 is a pro-drug of Barasertib-hQPA, which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.
View activity & pricesDC22228Fluzoparib
Fluzoparib (SHR-3162) is a novel, potent and orally available inhibitor of PARP; potently inhibited PARP1 enzyme activity and induced DNA double-strand breaks, G2/M arrest and apoptosis in homologous recombination…
View activity & pricesDC4119YM155
YM-155 is a survivin inhibitor with an IC50 of 0.54 nM.
View activity & pricesDC10871MTX211
MTX-211 is a dual inhibitor of EGFR and PI3K, used for the treatment of cancer and other diseases.
View activity & pricesDC1062GNF-2
GNF-2 is a highly selective non-ATP competitive inhibitor of oncogenic Bcr-Abl activity (IC50 = 0.14 μM).IC50 value: 0.14 uM [1]Target: Bcr-Ablin vitro: Ba/F3 cells harboring native or T315I mutated Bcr-Abl constructs…
View activity & pricesDC3138Canertinib dihydrochloride
Canertinib dihydrochloride (CI-1033;PD-183805) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM.
View activity & pricesDCAPI1150Calcitriol (Rocaltrol)
Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
View activity & pricesDC7101CGK733
CGK733 is a potent ATM/ATR inhibitor, used for the research of cancer.
View activity & pricesDC2086PF-670462
PF-670462 is a potent and selective inhibitor of casein kinase (CK1ε and CK1δ), with IC50s of 7.7 nM and 14 nM, respectively.
View activity & pricesDC7550PBIT
PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1(JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1 ) histone demethylase an IC50 of about 3 μM . PBIT also inhibits JARID1A and JARID1C with…
View activity & pricesDC7154BMS-833923 (XL-139)
BMS-833923 (XL-139) is an orally bioavailable small-molecule inhibitor of Smoothened with potential antineoplastic activity; inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21…
View activity & pricesDCAPI1434Romidepsin（FK-228）
Romidepsin is a potent HDAC1 and HDAC2 inhibitor with IC50s of 36 and 47 nM, respectively.
View activity & pricesDC60394PU-WS13
PU-WS13 is a selective Grp94 inhibitor, with an EC50 of 0.22 μM.
View activity & pricesDC7071AWD 131-138(Imepitoin)
AWD 131-138(Imepitoin) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.
View activity & pricesDC10700Seladelpar
Seladelpar is an orally active, potent (50% effect concentration EC50 2 nM), and specific PPAR-δ agonist.
View activity & pricesDC7035Merestinib(LY2801653 dihydrochloride)
Merestinib dihydrochloride (LY2801653 dihydrochloride) is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (Ki) of 2 nM.
View activity & pricesDC7751FLLL32
FLLL32 is a STAT3 inhibitor derived from the natural product curcumin. FLLL32 retains the cellular response to cytokines with anti-tumor activity[1].
View activity & pricesDC8643LY2835219 free base (Abemaciclib)
Abemaciclib (LY2835219) is a selective CDK4/6 inhibitor with IC50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively.
View activity & pricesDC9424Fenoldopam (mesylate)
Fenoldopam(SKF 82526) mesylate is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.Target: D1 ReceptorFenoldopam is a selective dopamine-1 (DA1) agonist with…
View activity & pricesDC10821PKG drug G1
PKG drug G1 targets C42 of PKG Iα. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.
View activity & pricesDC7799AZD2932
AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3 and c-Kit with IC50s of 8, 4, 7 and 9 nM in cell assay, respectively.
View activity & pricesDC7179Ki16425
Ki16425 is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with Kis of 0.34 μM and 0.93 μM, respectively.
View activity & pricesDC5021PD153035 HCl (SU-5271, AG1517)
PD153035 (ZM 252868;AG 1517;Tyrphostin AG 1517;SU 5271) is a potent EGFR inhibitor with Ki and IC50 of 6 and 25 pM, respectively.
View activity & pricesDC7253CID-2011756
CID 2011756 is an ATP competitive PKD inhibitor, with an IC50 of 3.2 µM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50, 0.6 and 0.7 µM, respectively). CID…
View activity & pricesDC9264S1RA hydrochloride
S1RA Hcl(E-52862 Hcl) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
View activity & pricesDC7528VGX-1027(GIT 27)
VGX-1027(GIT27) is an isoxazole compound that exhibits various immunomodulatory properties; reduce the secretion of IL-1beta, TNF-alpha and IL-10 from purified murine macrophages.Administration of VGX-1027 to NOD mice…
View activity & pricesDC10792DIM-C-pPhOCH3(C-DIM5)
DIM-C-pPhOCH3 is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.
View activity & pricesDC7314Tenovin-3
Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.Target: p53in vitro: Tenovins inhibit the activities of human SirT1 and SirT2, two members of the NAD+-dependent class III…
View activity & pricesDC8036CAY10603
CAY10603 is a potent and selective HDAC6 inhibitor, with an IC50 of 2 pM; CAY10603 also inhibits HDAC1, HDAC2, HDAC3, HDAC8, HDAC10, with IC50s of 271, 252, 0.42, 6851, 90.7 nM.
View activity & pricesDC7193MBX-2982
MBX-2982 is a selective, orally-available G protein-coupled receptor 119 (GPR119) agonist.
View activity & pricesDC7341WZ 811
WZ811 is a potent CXCR4 antagonist, effectively inhibits TN14003 binding to CXCR4, with an EC50 of 0.3 nM.
View activity & pricesDC4174NVP-AEW541
NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 0.15 μM, also inhibits InsR, with IC50 of 0.14 μM.
View activity & pricesDC7106Rociletinib (CO-1686)
Rociletinib (CO-1686) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the Ki values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively.
View activity & pricesStructure information available on request
DC8361CDDO(Bardoxolone; RTA 401)
Bardoxolone is a novel nuclear regulator factor (Nrf-2) activator.
View activity & pricesDC7386CK-636
CK-636 is a cell permeable inhibitor of Arp2/3 complex, that could inhibit actin polymerization, with IC50 values of 4 μM, 24 μM and 32 μM for human, fission yeast and bovine, respectively.
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