DC5002BIX02188 (BIX 02188）
BIX02188 is a potent MEK5-selective inhibitor with an IC50 of 4.3 nM. BIX02188 inhibits ERK5 catalytic activity, with an IC50 of 810 nM.
View activity & pricesDC Chemicals · Research reagentsDC5002 
DC7723
DC1099
DC8473
DC7308
DC10048
DC7868
DC7488
DC8401
DC9808
DC1069
DC74339
DC1056
DC4177
MEK (MAP2K)
14 products · Page 1 of 1
All small molecule research tools
DC5002DC7723OTS-964
OTS-964 is a potent TOPK inhibitor (IC50=28 nM), which inhibits TOPK kinase activity with high affinity and selectivity.
View activity & pricesDC1099Trametinib
Trametinib is a potent MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Due to the poor solubility of Trametinib, Trametinib DMSO solvate (Cat. No.: HY-10999A) is recommeded.
View activity & pricesDC8473Vacquinol-1
Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells.
View activity & pricesDC7308TAK-733
TAK-733 is a potent and selective MEK allosteric site inhibitor with an IC50 of 3.2 nM.
View activity & pricesDC10048APS-2-79
APS-2-79 behaves as a kinase suppressor of Ras (KSR)-dependent antagonist of RAF-mediated MEK phosphorylation. APS-2-79 binds directly to KSR2 within the KSR2-MEK1 complex with an IC 50 of 120±23 nM for KSR2.
View activity & pricesDC7868AS703026（Pimasertib）
Pimasertib (AS703026) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2, used for cancer treatment.
View activity & pricesDC7488RO4987655
RO4987655 is an orally active and highly selective MEK inhibitor with an IC50 of 5.2 nM for inhibition of MEK1/MEK2.
View activity & pricesDC8401BI-847325
BI-847325 is an ATP competitive dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.
View activity & pricesDC9808APS-2-79 hydrochloride
APS-2-79 hydrochloride behaves as a kinase suppressor of Ras (KSR)-dependent antagonist of RAF-mediated MEK phosphorylation. APS-2-79 binds directly to KSR2 within the KSR2-MEK1 complex with an IC 50 of 120±23 nM for…
View activity & pricesDC1069AZD6244 (Selumetinib,ARRY-142886)
Selumetinib is a highly potent MEK inhibitor, with an IC50 of 14 nM against MEK1.
View activity & pricesDC74339HRX-0233
HRX-0233 (HRX0233) is a potent and selective inhibitor of MAP2K4 (MKK4), a kinase involved in the stress-activated protein kinase (SAPK) signaling pathway. MAP2K4 plays a role in regulating cellular responses to…
View activity & pricesDC1056PD0325901 (Mirdametinib)
PD0325901 is a selective and cell permeable MEK inhibitor with an IC50 of 0.33 nM.
View activity & pricesDC4177Cobimetinib(GDC-0973; XL518)
Cobimetinib (GDC-0973, RG7420) is a potent, selective and oral MEK inhibitor with an IC50 of 4.2 nM for MEK1.
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