Explore ionizable lipids with reported antioxidant or reactive-oxygen-species-scavenging activity in the cited study context.
4 products currently listedResearch-use products only
Evidence noteCategory membership indicates research relevance. Organ targeting, cell specificity and performance must be verified from the formulation and study conditions cited for each product.
In vitro and in vivo AO12 is an antioxidant lipid evaluated for reactive-species scavenging, RNA protection and delivery in inflammation-associated models.
[1] Source Main Figure 2; antioxidant screening and RNA-protection experiments
In vitro and in vivo DA lipid contains a dopamine-derived antioxidant moiety and was evaluated for reactive-oxygen-species scavenging during mRNA delivery.
[3] Source Primary abstract; Main Figure 1a–d; SI Figure S15
In vitro AO16-containing LNPs were evaluated in the in vitro reactive-species screening; AO12 animal efficacy is not assigned to AO16.
[1] Source Main Figure 2 candidate library; SI antioxidant screening; prior documents/dcl0001/instructions.html
Each entry identifies the reported lipid or complete formulation, experimental setting and source. Reference products and limited-expression findings are labeled in their study context.
DA lipid is a dopamine-derived ionizable lipid incorporating a catechol antioxidant headgroup, one tertiary amine and two ester-linked branched hydrophobic tails. In the cited study, DA lipid and DA lipid nanoparticles scavenged reactive oxygen species more effectively than their oxidized ODA counterparts. DA LNPs supported higher mRNA-derived protein expression than ODA LNPs in DC2.4 cells and after intramuscular administration in mice, with expression comparable to ALC-0315 LNPs. OVA mRNA-loaded DA LNPs improved antigen presentation and suppressed tumor growth in a prophylactic B16-OVA melanoma model relative to ODA LNPs. These results support research into antioxidant mRNA delivery and preventive cancer vaccination.
AO12 is a novel antioxidant ionizable lipid derived from SM-102 skeleton with para-hydroxyphenyl propionic acid side chains. Integrated into LNPs, it efficiently scavenges diverse reactive oxygen species including ·OH and ONOO⁻, shielding encapsulated mRNA from oxidative degradation. It retains fine LNP formulation features and cellular uptake capacity of conventional lipids, boosting in vivo mRNA translation. Applied for regenerative mRNA therapy and CRISPR gene editing against fibrosis and inflammatory disorders.
C-a16 is an ionizable lipid engineered through Mannich reaction chemistry, designed to revolutionize mRNA delivery by synergizing high efficiency with minimized immune activation. Synthesized by reacting a phenolic tail derivative, formaldehyde, and a branched tertiary amine core under optimized ethanol conditions, this lipid integrates antioxidant phenol groups directly into its structure. These phenol moieties serve as intrinsic radical scavengers, effectively neutralizing intracellular reactive oxygen species that typically degrade mRNA and trigger inflammation.In lipid nanoparticle formulations, C-a16 constitutes the functional backbone, enabling superior mRNA encapsulation efficiency while maintaining a stable nanoparticle size of approximately 80–100 nm. Critically, it outperforms conventional lipids like DLin-MC3-DMA by achieving significantly higher target-protein expression in vivo alongside markedly reduced pro-inflammatory cytokine secretion. The antioxidant capability is not incidental but fundamental—quenching the phenol groups drastically diminishes both ROS suppression and delivery efficacy, confirming the design's mechanistic elegance.C-a16 represents a paradigm shift: its biomimetic antioxidant architecture addresses the chronic trade-off between delivery potency and immunogenicity, unlocking safer therapeutic applications for vaccines and gene therapies.
