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Ionizable lipids / Antioxidant lipid AO16
Antioxidant lipid AO16 chemical structure
Product imageResearch use only
CAT. NO. DCL0001Featured

Antioxidant lipid AO16

Antioxidant ionizable lipids · Featured lipid products · phenylpropanoids

Ionizable lipid for LNP and nucleic-acid delivery research.

Research highlights
AO16 is the 3,4-dihydroxyphenylpropionate member of the antioxidant lipid series reported in the cited study.At 0.05 mM reactive-species challenge, AO16 LNPs had a reported antioxidant score of 67 versus 57 for the commercial control LNP.The paper screened AO16 in vitro; it did not report an AO16-specific in vivo efficacy study or standalone pKa.Formulation ratios are reported as AO16:SM-102:DSPC:cholesterol:DMG-PEG2000; N/P was not reported.
Derived from the cited study; not a product specification or performance guarantee.

Pack size & price

USD
Total$650
We match the best price and quality on market.
Research use onlyShips from ShanghaiIce-pack transportPure lipid recommended
Product overview

Description & Application

AO16 is a literature-reported antioxidant ionizable lipid derived from the SM-102 scaffold.

CAS No.Not available
Chemical NameAntioxidant lipid AO16
SynonymsAO16; antioxidant lipid AO16
SMILESCCCCCCCCCCCOC(=O)CCCCCN(CCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC)CCOC(=O)CCc1cc(O)c(O)cc1
FormulaC53H95NO8
M.Wt874.34
Purity>98%
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
PublicationLi B, Zhao M, Yang B, et al. Nature Communications. 2026;17:7166. DOI: 10.1038/s41467-026-73512-3.

Literature-reported formulation composition

The paper reports AO16 as an additive relative to SM-102. The values below retain the reported ratios; normalized mol% is shown separately.

ComponentReported molar ratioNormalized mol%Role
AO162.502.44Ionizable lipid
SM-10250.0048.78Ionizable lipid
DSPC10.009.76Helper phospholipid
Cholesterol38.5037.56Sterol
DMG-PEG20001.501.46PEG lipid
Reported ratio sum102.50100.00AO16 addition relative to SM-102
Not reported in the cited article
20:1 (total lipid:mRNA); this is not an N/P ratio.
Citrate buffer pH 4.0 and ethanol phase at 3:1 aqueous:ethanol, vortexed 5 min, incubated 10 min, then dialyzed against PBS for at least 12 h.
HEK293T reporter assay and reactive-species challenge; AO16-specific data are in vitro screening data.
mRNA screening used 250 ng per well; oxidative challenge used 0.05–0.50 mM reactive species for 2 h before dialysis.

AO16 literature screening results

Literature-reported67% for AO16 LNPs versus 57% for the commercial control LNPReactive species panel: O2−, ·OH, H2O2, ClO− and ONOO−; 5 mol% AO16 relative to SM-102Supplementary Information p. 76, Supplementary Table 2.
Literature-reported32% for AO16 LNPs versus 37% for the commercial control LNPSame five-species panel at the higher challenge concentrationSupplementary Information p. 78, Supplementary Table 2.
Literature-reportedO2− 87; ·OH 42; H2O2 72; ClO− 69; ONOO− 64These are the source table values used to calculate the reported average score of 67.Supplementary Information p. 76, Supplementary Table 2.

Interpretation boundary

What the source supports

The cited article supports AO16 as an in vitro antioxidant-lipid screening candidate with the formulation and challenge conditions listed above.

Nature Communications 2026;17:7166; DOI 10.1038/s41467-026-73512-3.
What is not assigned to AO16

AO12 was the lead selected for the paper's later regeneration, biodistribution and gene-editing experiments. Those AO12-specific animal results are not presented as AO16 product performance.

Product-page evidence boundary.
Literature Data DisclaimerAll formulation parameters and performance values shown here are derived from the cited publication and supplementary information. They are reference data, not product release specifications or performance guarantees. DC Chemicals supplies the lipid compound only.
Cited literatureLi B, Zhao M, Yang B, et al. Antioxidant lipid nanoparticles enhance mRNA stability for regeneration therapy and gene editing. Nature Communications. 2026;17:7166. DOI: 10.1038/s41467-026-73512-3
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg11.6504 mL2.3301 mL1.1650 mL
25 mg29.1260 mL5.8252 mL2.9126 mL
50 mg58.2520 mL11.6504 mL5.8252 mL
100 mg116.5039 mL23.3008 mL11.6504 mL
250 mg291.2599 mL58.2520 mL29.1260 mL

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.
How should I measure a small amount of oily or viscous lipid?
Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.
Can you support formulation optimization and scale-up?
Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.