Lipid composition
Compare candidate ionizable lipids, helper phospholipids, sterols and PEG lipids within an agreed formulation design space.
Explore the lipid catalog →A defined formulation study for your RNA program
LNP Formulation Optimization Service
Build a formulation optimization project around your payload, target application and measurable goals. Discuss lipid selection, formulation ratios, preparation conditions and a staged evaluation plan.
Start with the delivery question
Define the payload, biological model, administration route and reference formulation first. Then agree a focused screening plan, its controls and the criteria for advancing candidates. Assay availability, experimental scope and acceptance criteria are confirmed before the project starts.
Ratios & payload loading
Evaluate component molar fractions and payload loading. Record N/P and lipid-to-RNA mass ratio separately, with their calculation basis defined.
Explore formulation components →Preparation conditions
Discuss mixing approach, flow conditions where applicable, buffer pH, concentrations, solvent removal and final formulation buffer.
Need a custom lipid? →Application-driven evaluation
Define the relevant model and endpoint, such as reporter expression or target knockdown, alongside suitable controls and tolerability readouts.
Browse siRNA delivery products →Choose the evaluation package
| Evaluation area | Items to discuss in the study plan |
|---|---|
| Particle attributes | Particle size, polydispersity and measurement conditions; surface charge or apparent pKa where relevant and included in scope. |
| Payload & composition | RNA concentration, encapsulation measurement, recovery and the agreed approach to RNA integrity or composition analysis. |
| Functional activity | Expression or knockdown in the agreed model, with dose, time point, normalization and biological replicates specified. |
| Tolerability | Cell viability or other agreed endpoints evaluated alongside activity. Confirm model-specific testing requirements during scoping. |
| Stability | Defined storage conditions, time points and readouts; include freeze-thaw or handling studies only when relevant to the project. |
| Reproducibility | Repeat preparation of selected formulations and comparison of agreed quality and functional readouts. |
| Advanced studies | Discuss requirements for in vivo, biodistribution or specialized assays separately; availability and scope require confirmation. |
Working together
From project brief to agreed deliverables
Define the target profile
Agree the payload, application, current formulation, key problem and measurable success criteria.
Design the screen
Choose factors, ranges, controls and a screening matrix; agree sample requirements and assay scope.
Compare & refine
Evaluate the agreed readouts, review trade-offs and select candidates for a focused second round.
Confirm & document
Confirm selected candidates within scope and provide the agreed formulation records, methods and results.
A report you can use for the next experiment
Agree a report containing formulation identifiers, component ratios, preparation records, assay methods, results and a comparison of candidates. Separate measured results from interpretation and recommendations. Record model, dose, time point and replicate details so that comparisons remain traceable.
Start a conversation
Tell us about your project
Include payload type and size, target model, administration route, current formulation, available material and the main limitation you want to address.
Opens your email application with a project brief. Add your details and attachments, then send.
For research use only. Project scope, analytical methods and delivery schedule are agreed during quotation.