DC7036TUG-770
TUG-770 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist with EC50 of 6 nM for hFFA1.
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Small Molecule Research Tools
2816 products · Page 18 of 59
Browse 372 research categories
DC7036DC10489UNC926
UNC-926 is a methyl-lysine (Kme) reader domain inhibitor; inhibits L3MBTL1 with an IC50 of 3.9 μM.
View activity & pricesDC9272K 858
K858 Racemic is an ATP-uncompetitive inhibitor of Eg5 with an IC50 of 1.3 μM.
View activity & pricesDC2085Compound 401
Compound 401 is a synthetic inhibitor of DNA-PK (IC50 = 0.28 μM) that also targets mTOR but not PI3K in vitro.
View activity & pricesDC7301SSR128129E
SSR128129E is an orally available and allosteric FGFR inhibitor with an IC50 of 1.9 μM for FGFR1.
View activity & pricesDC9761RK-33
RK-33 is an RNA helicase inhibitor against DDX3, and inhibits its helicase activity.
View activity & pricesDC8281Ozanimod (RPC1063)
Ozanimod is a potent and selective S1P1 and S1P5 receptor agonist with EC50s of 410±160 pM and 11±4.3 nM in [35S]-GTPγS binding, respectively.
View activity & pricesDC10048APS-2-79
APS-2-79 behaves as a kinase suppressor of Ras (KSR)-dependent antagonist of RAF-mediated MEK phosphorylation. APS-2-79 binds directly to KSR2 within the KSR2-MEK1 complex with an IC 50 of 120±23 nM for KSR2.
View activity & pricesDC10067T-5601640（T56-LIMKi）
T56-LIMKi is a selective inhibitor of LIMK2; inhibits the growth of Panc-1 cells with an IC50 of 35.2 μM.
View activity & pricesDC7794MG149
MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM); little potent for PCAF and p300(IC50 >200 uM).IC50 value: 74/47 uM (Tip60/MOF) [1]Target: Tip60/MOFMG 149, at…
View activity & pricesDC8485E-64d(Aloxistatin)
Aloxistatin (E64d) is a cell-permeable and irreversible broad-spectrum cysteine protease inhibitor.
View activity & pricesDC3133NVP-BGT226 (BGT226）
NVP-BGT226 is a potent pan-class I PI3K and mTOR catalytic inhibitor with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ.
View activity & pricesDCAPI1196Eltrombopag (SB-497115-GR)
Eltrombopag is a thrombopoietin (TPO) receptor agonist developed for certain conditions that lead to thrombocytopenia.
View activity & pricesDC7470MPI-0479605
MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC50 of 1.8 nM.
View activity & pricesDC9639iCRT 14
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT), with IC50 of 40.3 nM against Wnt responsive STF16 luciferase.
View activity & pricesDC7939CH-223191
CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 blocks the binding of TCDD to AhR with an IC50 of 0.03 µM.
View activity & pricesDC7226Perampanel(E2007）
Perampanel(E2007; ER 155055-90) is a selective noncompetitive AMPA-type glutamate receptor antagonist which has demonstrated anticonvulsant activity in experimental seizure models and antiepileptic activity in clinical…
View activity & pricesDC7337VS-5584
VS-5584 is a pan-PI3K/mTOR kinase inhibitor with IC50s of 16 nM, 68 nM, 42 nM, 25 nM, and 37 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively. VS-5584 simultaneously blocks mTORC2 as well as mTORC1.
View activity & pricesDC8089BVT 2733(BVT.2733)
BVT 2733 is a new, small molecule, non-steroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1).
View activity & pricesDC7582KX1-004
KX1-004 is a potent small molecule inhibitor of Src-PTK as a potential protective drug for NIHL.IC50 value:Target: Src-PTK inhibitorKX1-004, KX1-005 and KX1-174 as potential protective drugs for NIHL. Chinchillas were…
View activity & pricesDC7689Evofosfamide(TH-302)
Evofosfamide (TH-302) is a hypoxia-activated prodrug with IC50 of 10 μM and 1000 μM in hypoxia (N2) and normoxia (21% O2), respectively.
View activity & pricesDC100142-PMPA(NAALADaseinhibitor)
2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM.
View activity & pricesDC9805Preladenant(SCH420814)
Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a Ki of 1.1 nM and has over 1000-fold selectivity over other adenosine receptors.
View activity & pricesDC9981TUG891
TUG-891 is a potent and selective agonist of the long chain free fatty acid (LCFA) receptor 4.
View activity & pricesDC106163-TYP
3-TYP is a selective SIRT3 inhibitor, with an IC50 of 16 nM, more potent over SIRT1 (IC50=88 nM), SIRT2 (IC50=92 nM).
View activity & pricesDC9256KS176
KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory…
View activity & pricesDC1016VU-0357121(VU0357121)
VU0357121 is a novel positive and highly selective allosteric modulator (PAM) of mGlu5R with EC50 of 33 nM.
View activity & pricesDC9723PBTZ169
Macozinone is a new drug candicate that inhibits decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1), more efficiently than BTZ043target: DprE1In vitro: PBTZ169, inhibit decaprenylphosphoryl-β-d-ribose 2′-oxidase…
View activity & pricesDC10843CGP 52432
CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM.
View activity & pricesDC10074MX69
MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.
View activity & pricesDC8648GSK4112
GSKGSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα
View activity & pricesDC23993Aldose reductase-IN-1
An inhibitor of aldose reductase with IC50 of 28.9 pM; extracted from Patent WO2014113380 A1 and US20130225592.
View activity & pricesStructure information available on request
DC8934Irinotecan
Irinotecan is a water soluble topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex.
View activity & pricesDC7320Ganetespib(STA-9090)
Ganetespib is a heat shock protein 90 (HSP90) inhibitor which exhibits potent cytotoxicity in a wide variety of hematological and solid tumor cell lines.
View activity & pricesDC7989PEPA
PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
View activity & pricesDC8826DB07268
DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM.
View activity & pricesDC9292CHIR-090
CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase. It binds to E. coli LpxC with a Ki of 4.0 nM.
View activity & pricesDC7168Ki20227
Ki-20227 is a highly selective c-Fms tyrosine kinase(CSF1R) inhibitor with IC50 value of 2 nM; 6 fold and > 100 fold selectivity over VEGFR2(IC50=12 nM) and c-Kit/PDGFRβ(IC50=451/217 nM), respectively.IC50 value:…
View activity & pricesDC9954A 804598
A-804598 is a novel, competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively.
View activity & pricesDC10439Vorasidenib (AG881)
Vorasidenib is a pan isocitrate dehydrogenase (IDH) inhibitor.
View activity & pricesDC8437AGK2
AGK2 is a selective SIRT2 inhibitor with IC50 of 3.5 μM. AGK2 can also inhibit SIRT1 and SIRT3 with IC50 of 30 and 91 μM, respectively.
View activity & pricesDC9775WZ3146
WZ3146 is a mutant selective EGFR inhibitor with IC50s of 2, 2, 5, 14 and 66 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746_A750, EGFRE746_A750/T790M and EGFR, respectively.
View activity & pricesDC11486D-Luciferin (potassium salt)
D-Luciferin potassium salt is the substrate of luciferases that catalyze the production of light in bioluminescent insects.
View activity & pricesDC9765CERC-501(LY-2456302,Aticaprant)
LY-2456302 is a potent and centrally-penetrant kappa opioid receptor antagonist with a Ki of 0.807 nM.
View activity & pricesDC7263RGFP 966
RGFP966 is a highly selective HDAC3 inhibitor with an IC50 of 80 nM and shows no inhibition to other HDACs at concentrations up to 15 μM.
View activity & pricesDC9741Mad2 inhibitor-1 (M2I-1)
M2I-1 a small Mad2 inhibitor-1. the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential proteinprotein interaction (PPI) within the SAC. It can disturbs conformational dynamics of Mad2…
View activity & pricesDC9270Eg5 Inhibitor III（Dimethylenastron）
Dimethylenastron is a potent Eg5 inhibitor, with an IC50 of 200 nM.
View activity & pricesDC7508SU 5402
SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGFRβ, respectively.
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