DC7076AZD-7762
AZD-7762 is a potent ATP-competitive checkpoint kinase (Chk) inhibitor in with an IC50 of 5 nM for Chk1.
View activity & pricesDC Chemicals · Research reagentsDC7076 
DC7294
DC7177
DC10034
DC7141
DC7943
DC11089
DC8103
DC7466
DC7308
DC7544
DC3169
DC3133
DC10563
DC7290
DC7369
DC9829
DC7488
DC8401
DC7812
DC11303
DC7081
DC3168
DC8023
DC11633
DC8418
DC7810
DC8223
DC10864
DC10408
DC9679
DC5084
DC8489
DC10463
DC10451
Solid Tumors
35 products · Page 1 of 1
All small molecule research tools
DC7076DC7294SGX-523
SGX-523 is a selective Met inhibitor with IC50 of 4 nM, no activity to BRAFV599E, c-Raf, Abl and p38α.
View activity & pricesDC7177JNJ 38877605
JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.
View activity & pricesDC10034GLPG0187
GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits αvβ1-integrin with an IC50 of 1.3 nM.
View activity & pricesDC7141Omipalisib
Omipalisib (GSK2126458) is a highly selective and potent inhibitor of PI3K with Kis of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively.
View activity & pricesDC7943LYS6K2(LY2584702) tosylate salt
LY-2584702 tosylate salt is a selective ATP competitive inhibitor of p70S6K with an IC50 of 4 nM. In S6K1 enzyme assay, the IC50 of LY-2584702 is 2 nM.
View activity & pricesDC11089TAS-120 (Futibatinib)
TAS-120 is a novel, potent and highly selective FGFR inhibitor, used for antitumor treatment.
View activity & pricesDC8103BLZ-945
BLZ945 is a potent, selective and brain-penetrant CSF-1R inhibitor with an IC50 of 1 nM, showing more than 1,000-fold selectivity against its closest receptor tyrosine kinase homologs.
View activity & pricesDC7466MK-5108
MK-5108 inhibits Aurora-A activity in an ATP-competitive manner. MK-5108 shows robust selectivity against the other family kinases Aurora-B (220-fold) and Aurora-C (190-fold) in the biochemical assay. MK-5108 also…
View activity & pricesDC7308TAK-733
TAK-733 is a potent and selective MEK allosteric site inhibitor with an IC50 of 3.2 nM.
View activity & pricesDC7544CUDC-101
CUDC-101 is a potent inhibitor of HDAC, EGFR, and HER2 with IC50s of 4.4, 2.4, and 15.7 nM, respectively.
View activity & pricesDC3169PF-562271
PF-562271 is a potent ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase, with an IC50 of 1.5 nM and 13 nM, respectively.
View activity & pricesDC3133NVP-BGT226 (BGT226）
NVP-BGT226 is a potent pan-class I PI3K and mTOR catalytic inhibitor with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ.
View activity & pricesDC10563E-7046
E7046 is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM, exhibiting anti-tumor activities.
View activity & pricesDC7290Semaxanib (SU5416)
Semaxinib (SU5416) is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) with an IC50 of 1.23 μM.
View activity & pricesDC7369AZD5438
AZD-5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM in cell-free assays. It also inhibits GSK3β, but is less potent to CDK5/6.
View activity & pricesDC9829IPI-549
IPI549 is a potent and selective PI3Kγ inhibitor with an IC50 of 16 nM.
View activity & pricesDC7488RO4987655
RO4987655 is an orally active and highly selective MEK inhibitor with an IC50 of 5.2 nM for inhibition of MEK1/MEK2.
View activity & pricesDC8401BI-847325
BI-847325 is an ATP competitive dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.
View activity & pricesDC7812GSK923295
GSK-923295 is a special, allosteric inhibitor of CENP-E kinesin motor ATPase activity, with Ki of 3.2±0.2 nM and 1.6± 0.1 nM for human and canine, respectively.
View activity & pricesDC11303CT7001(Samuraciclib hydrochloride）
CT7001 hydrochloride is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively.
View activity & pricesDC7081PF-04217903
PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM, susceptible to oncogenic mutations (no activity to Y1230C mutant).
View activity & pricesDC3168PF-562271 besylate
PF-562271 (besylate) is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 13 nM, and has > 100-fold selectivity against other protein kinases, except for some CDKs.
View activity & pricesDC8023KX2-391
KX2-391 is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
View activity & pricesDC11633TAK-243
TAK-243 is a potent and selective ubiquitin-like modifier activating enzyme 1 (UBA1) inhibitor.
View activity & pricesDC8418CH5183284 (Debio-1347)
CH5183284 is an orally available and selective FGFR inhibitor with IC50s of 9.3, 7.6, and 22 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.
View activity & pricesDC7810CX-5461
CX-5461 is a potent and oral rRNA synthesis inhibitor. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively.
View activity & pricesDC8223TP-0903
TP-0903 is a potent and selective Axl receptor tyrosine kinase inhibitor with an IC50 value of 27 nM.
View activity & pricesDC10864C188-9
C188-9 is a Stat3 inhibitor, with a Kd of 4.7 nM.
View activity & pricesDC10408BAY1125976
BAY1125976 is a selective allosteric Akt1/Akt2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.
View activity & pricesDC9679BAY1217389
BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM.
View activity & pricesDC5084AZD-8055
AZD-8055 is a novel ATP-competitive inhibitor of mTOR kinase with an IC50 of 0.8 nM. AZD-8055 inhibits both mTORC1 and mTORC2.
View activity & pricesDC8489ETC-159
ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
View activity & pricesDC10463Repotrectinib(TPX-005)
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.
View activity & pricesDC10451PFK158
PFK-158 is a potent and selective inhibitor of PFKFB3 that is currently being investigated in a phase I study in patients with advanced solid malignancies.
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