Repotrectinib(TPX-005) chemical structure

Chemical structureResearch use only

CAT. NO. DC10463Featured

Repotrectinib(TPX-005)

Name: Repotrectinib(TPX-005)
Brand: DC Chemicals
SKU: DC10463
Price: 450.0 USD

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TotalUS$450

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Product overview

Description & Application

Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.

Parameter	Value
Chemical Name	Repotrectinib
CAS No.	1802220-02-5
Synonyms	TPX-0005;Repotrectinib;Ropotrectinib;08O3FQ4UNP;Repotrectinib (USAN);Repotrectinib [USAN];GTPL10316;TPX0005;TPX 0005 [WHO-DD];BDBM374727;US10246466
Formula	C18H18FN5O2
M.Wt	355.3662
SMILES	FC1C=CC2=C(C=1)[C@@H](C)NC1C=CN3C(=C(C=N3)C(NC[C@H](C)O2)=O)N=1
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.

In Vitro

Repotrectinib (TPX-0005) effectively overcomes this primary resistance (IC50 100 nM in cell proliferation assay) with strong inhibition of the phosphorylation of EML4-ALK (IC50 13 nM) and the SRC substrate paxillin (IC50 107 nM). Repotrectinib inhibits H2228 cell migration in a wound healing assay with similar activity to saracatinib[1].

In Vivo

Repotrectinib (TPX-0005) effectively inhibits tumor growth in vivo in ALK WT and ALK G1202R xenografts[1].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

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