DC8444Sabutoclax
Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC50s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively.
View activity & pricesDC Chemicals · Research reagentsDC8444 
DC2002
DC5005
DC7233
DC7950
DC9768
DC9955
DC4127
DC12163
DC10447
DC9296
DC50166
DC59120
DC70246
Bcl-2
14 products · Page 1 of 1
All small molecule research tools
DC8444DC2002Venetoclax(ABT-199)
Venetoclax (ABT-199; GDC-0199) is a highly selective, orally bioavailable small-molecule inhibitor of Bcl-2, exhibiting sub-nanomolar binding affinity with a Ki of less than 0.01 nM. This compound has been demonstrated…
View activity & pricesDC5005tw-37
TW-37 is a potent Bcl-2 inhibitor with Ki values of 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL, respectively.
View activity & pricesDC7233Pifithrin-u
Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.
View activity & pricesDC7950UMI-77
UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of…
View activity & pricesDC9768A1155463
A-1155463 is a highly potent and selective BCL-XL inhibitor with an EC50 of 70 nM in Molt-4 cell.
View activity & pricesDC9955BCL6 inhibitor(CID5721353)
CID5721353 is an inhibitor of BCL6 with an IC50 value of 212 μM, which corresponds to a Ki of 147 μM.
View activity & pricesDC4127ABT-263 (Navitoclax)
Navitoclax (ABT-263) is a potent and oral Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM.
View activity & pricesDC12163S55746 (BLC201)
S55746 is an orally active, selective and potent BCL-2 inhibitor, with a Ki of 1.3 nM.
View activity & pricesDC10447FX1
FX1 is a potent and specific BCL6 inhibitor, with an IC50 of around 35 μM.
View activity & pricesDC9296A-1331852
A-1331852 is an orally available BCL-XL selective inhibitor with a Ki of less than 10 pM.
View activity & pricesDC50166Bim-IN-1
Bim-IN-1 is a potent Bim expression inhibitor. Bim-IN-1 reduces Bim expression levels and has little inhibitory effect upon protein kinase A activity and minimal toxicity.
View activity & pricesDC59120BTSA1.2
BTSA1.2 is a rationalized BTSA1 analog with improved binding to BAX, cellular cytotoxicity, and better toleratence in vivo. Combination of BTSA1.2 with Navitoclax demonstrates synergistic efficacy in…
View activity & pricesDC70246BFL-1 inhibitor 4E14
BFL-1 inhibitor 4E14 (4E14) is a potent, selective, covalent BFL-1 inhibitor that disrupt BH3-binding activity with IC50 of 1.3 uM, targets a unique C55 residue in the BFL-1 groove.4E14 blocks BFL-1 suppression of…
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