BFL-1 inhibitor 4E14 chemical structure
Chemical structureResearch use only
CAT. NO. DC70246Featured

BFL-1 inhibitor 4E14

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TotalUS$500
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Product overview

Description & Application

BFL-1 inhibitor 4E14 (4E14) is a potent, selective, covalent BFL-1 inhibitor that disrupt BH3-binding activity with IC50 of 1.3 uM, targets a unique C55 residue in the BFL-1 groove.4E14 blocks BFL-1 suppression of BAX-mediated mitochondrial apoptosis.

ParameterValue
Chemical NameBFL-1 inhibitor 4E14
FormulaC19H28N4O2S2
M.Wt408.579
SMILESCC(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(=O)NCCSSCCN(C)C
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

BFL-1 inhibitor 4E14 (4E14) is a potent, selective, covalent BFL-1 inhibitor that disrupt BH3-binding activity with IC50 of 1.3 uM, targets a unique C55 residue in the BFL-1 groove.4E14 blocks BFL-1 suppression of BAX-mediated mitochondrial apoptosis.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

1. Edward P Harvey, et al. Cell Chem Biol. 2020 Jun 18;27(6):647-656.e6.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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