Sabutoclax chemical structure
Chemical structureResearch use only
CAT. NO. DC8444Featured

Sabutoclax

Pack Sizes & Prices

TotalUS$680
We match the best price and quality on market.
Product overview

Description & Application

Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC50s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively.

ParameterValue
Chemical Name[2,2'-Binaphthalene]-5,5'-dicarboxamide, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-, (1R)
CAS No.1228108-65-3
FormulaC42H40N2O8
M.Wt700.78
SMILESC(O)1=C2C(C(C(NC[C@@H](C3=CC=CC=C3)C)=O)=C(O)C(O)=C2)=CC(C)=C1C1=C(C)C=C2C(=C1O)C=C(O)C(O)=C2C(NC[C@@H](C1=CC=CC=C1)C)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC50s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

View online datasheetRequest COA / MSDS

Refer to the certificate supplied with your lot for batch-specific release results.

Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

Related research products

Venetoclax(ABT-199) chemical structureDC2002

Venetoclax(ABT-199)

Venetoclax (ABT-199; GDC-0199) is a highly selective, orally bioavailable small-molecule inhibitor of Bcl-2, exhibiting sub-nanomolar binding affinity with a Ki of less than 0.01 nM. This compound has been demonstrated…

View activity & prices
tw-37 chemical structureDC5005

tw-37

TW-37 is a potent Bcl-2 inhibitor with Ki values of 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL, respectively.

View activity & prices
UMI-77 chemical structureDC7950

UMI-77

UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of…

View activity & prices
ABT-263 (Navitoclax) chemical structureDC4127

ABT-263 (Navitoclax)

Navitoclax (ABT-263) is a potent and oral Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM.

View activity & prices

Cart

Request quotation