DC70426GAT1508
GAT1508 (GAT-1508) is a potent, specific activator for brain-expressed GIRK1/2 channels (EC50=75 nM), specifically activates the brain GIRK1/2 over the cardiac GIRK1/4; GAT1508 is an allosteric modulator of…
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Small Molecule Research Tools
2816 products · Page 13 of 59
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DC70426DC11089TAS-120 (Futibatinib)
TAS-120 is a novel, potent and highly selective FGFR inhibitor, used for antitumor treatment.
View activity & pricesDC8838Indirubin
Indirubin(Couroupitine B) is a purple 3,2- bisindole and a stable isomer of indigo isolated from Indigo naturalis (Apiaceae); anti-inflammatory and anticancer activities.IC50 value:Target:in vitro: The activation of…
View activity & pricesDC21522Balixafortide(POL6326)
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7.…
View activity & pricesDC7551RG3039(PF-06687859)
RG3039 (PF-06687859) is an orally bioavailable and brain-penetrant DcpS inhibitor with an IC50 of 0.069 nM.
View activity & pricesDC7053IWR-1
IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
View activity & pricesDC10542KIRA6
KIRA6 allosterically inhibits IRE1α RNase kinase activity with an IC50 of 0.6 µM.
View activity & pricesStructure information available on request
DCAPI1155Celastrol
Tripterin (Celastrol) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM.
View activity & pricesDC8458Akt Inhibitor VIII
AKT inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity with IC50s of 58 nM, 210 nM, and 2119 nM,…
View activity & pricesDC10574CID-25014542
CID-25014542 is novel inhibitor of Raf kinases.
View activity & pricesDC8065LY2409881 trihydrochloride
LY2409881 trihydrochloride is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM.
View activity & pricesDC12513RIP1 inhibitor GSK547
GSK547, a highly selective and potent RIP1 inhibitor, inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer[1].
View activity & pricesDC7679(R)PFI-2 HCl
PFI-2 hydrochloride is a a first-in-class, potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 with IC50 of 2 nM, 500 fold active than (S)-PFI-2.(R)-PFI-2 is highly selective…
View activity & pricesDC12624RAS activator compound 1
RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM; targets SOS1 induced biphasic modulation of RAS-GTP and ERK…
View activity & pricesDC60033SN-011
STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-mediated disease.
View activity & pricesDC7670SB-3CT
SB-3CT is a potent and competitive inhibitor of matrix metalloproteinase (MMP-2) and MMP-9.
View activity & pricesDC6910NS-1643
NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM).
View activity & pricesDC4123PHA-793887
PHA-793887 is a potent, ATP-competitive CDK inhibitor, can inhibit Cdk2, Cdk1, Cdk4, and Cdk9 with IC50s of 8 nM, 60 nM, 62 nM and 138 nM, respectively, and also inhibits glycogen synthase kinase 3β with an IC50 of 79…
View activity & pricesDC9298thiotepa
Thio-TEPA is a DNA alkylating agent, with antitumor activity.
View activity & pricesDC8266GW-627368X
GW627368(GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor(Ki= 100 nM) with additional human TP receptor affinity(Ki= 150 nM).IC50 value: Target: EP4 antagonistin vitro: At…
View activity & pricesDC7653THZ1 free base
THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM.
View activity & pricesDC8376TAS-301
TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, and inhibits PKC activation induced by PDGF.
View activity & pricesDC7015INCB024360 analogue(IDO-IN-1)
IDO5L is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 67 nM.
View activity & pricesDC8224Lifitegrast(SAR 1118)
Lifitegrast is an integrin lymphocyte function-associated antigen-1 (LFA-1) antagonist; inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM.
View activity & pricesDC9266Cabozantinib S-malate
Cabozantinib (S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
View activity & pricesDC8061SGC-707
SGC707 is a first-in-class PRMT3 chemical probe which is a potent, selective, and cell-active allosteric inhibitor of PRMT3 with IC50 of 31 nM.
View activity & pricesDC6302AZD2858
AZD2858 is a potent, orally active GSK-3 inhibitor, with IC50s of 0.9 and 5 nM for GSK-3α and GSK-3β, respectively, used in the research of fracture healing.
View activity & pricesDC2002Venetoclax(ABT-199)
Venetoclax (ABT-199; GDC-0199) is a highly selective, orally bioavailable small-molecule inhibitor of Bcl-2, exhibiting sub-nanomolar binding affinity with a Ki of less than 0.01 nM. This compound has been demonstrated…
View activity & pricesDC7098BI-D1870
BI-D1870 is an ATP-competitive inhibitor of RSK isoforms, with IC50s of 31 nM/24 nM/18 nM/15 nM for RSK1/SK2/SK3/SK4, respectively.
View activity & pricesDC1024Afatinib (BIBW2992)
For the detailed information about the solubility of Afatinib (BIBW2992) in water, the solubility of Afatinib (BIBW2992) in DMSO, the solubility of Afatinib (BIBW2992) in PBS buffer, the animal experiment（test） of…
View activity & pricesDC26141TPT-260
TPT-260(TPU260) is a thiophene thiourea derivative with molecule weight 260.00 in free base form; There is no formal name yet, we temporally call this molecule as TPT-260.IC50 value:Target:
View activity & pricesDC9304LY2334737
LY2334737 is an orally available prodrug of gemcitabine which is a nucleoside analog used as chemotherapy.IC50 Value:Target: Nucleoside analogin vitro: Five cell lines that express CES2 responded to LY2334737treatment.…
View activity & pricesDC5005tw-37
TW-37 is a potent Bcl-2 inhibitor with Ki values of 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL, respectively.
View activity & pricesDC7926AZ-6102
AZ6102 is a potent dual TNKS1 and TNKS2 inhibitor, with IC50s of 3 nM and 1 nM, respectively, and alao has 100-fold selectivity against other PARP family enzymes, with IC50s of 2.0 μM, 0.5 μM, and >3 μM, for PARP1,…
View activity & pricesDC7643DMH1
DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively.
View activity & pricesDC8866DEL-22379
DEL-22379 is an ERK dimerization Inhibitor. DEL-22379 readily binds to ERK2 with a Kd estimated in the low micromolar range, though binding is detectable even at low nanomolar concentrations. ERK2 dimerization is…
View activity & pricesDC9031Clodronate disodium
Clodronate disodium is available from DC Chemicals for laboratory research. Contact us for application-specific product information.
View activity & pricesDC5128MC1568
MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor, used for cancer research.
View activity & pricesDC8577FFA4 (GPR120) agonist GSK137647A
GSK137647A is a selective FFA4 agonist, with pEC50 of 6.3, 6.2, and 6.1 for human, Mouse and Rat FFA4, respectively.IC50 value: 6.3/6.2/6.1 (pEC50, for human/mouse/rat FFA4)Target: FFA4The pEC50s for Human , Mouse and…
View activity & pricesDC5183I-BET151
I-BET151 is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively.
View activity & pricesDC10878Raphin1
Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding…
View activity & pricesDC8012EPZ015666
EPZ015666 is an orally available inhibitor of PRMT5 with an IC50 of 22 nM.
View activity & pricesDC7312Tasisulam(LY573636)
Tasisulam is a small molecule antitumor agent that inhibits mitotic progression and induces vascular normalization. Tasisulam induces apoptosis via the intrinsic pathway[1].
View activity & pricesDC9305PF-CBP1(PF-06670910) hydrochloride
PF-CBP1 is potent and highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) that down regulates targets of CBP in macrophages primary neurons.
View activity & pricesDC8839RS-1
RS-1 is a RAD51 activator, and also increases CRISPR/Cas9-mediated knock-in efficiencies.
View activity & pricesDC8103BLZ-945
BLZ945 is a potent, selective and brain-penetrant CSF-1R inhibitor with an IC50 of 1 nM, showing more than 1,000-fold selectivity against its closest receptor tyrosine kinase homologs.
View activity & pricesDC8870Eupatilin
Eupatilin, a lipophilic flavonoid isolated from Artemisia species, is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.
View activity & pricesDC7233Pifithrin-u
Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.
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