DC9488Cilengitide
Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50s of 4 and 79 nM, respectively.
View activity & pricesDC Chemicals · Research reagentsDC9488 
DC9267
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Small Molecule Research Tools
2816 products · Page 14 of 59
Browse 372 research categories
DC9488DC9267EPZ015866
EPZ015866 is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 22 nM.
View activity & pricesDC7742K02288
K02288 is a potent inhibitor of ALK, and inhibits ALK1/2/3/6 with IC50s of 1.8/1.1/34.4/6.3 nM; K02288 is less potent against ALK4/5, with IC50s of 302 nM and 321 nM.
View activity & pricesDC8021Indoximod (NLG-8189)
Indoximod (D-1MT, NLG8189) is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor with a Ki of 19 μM.
View activity & pricesDC65513HYNIC-FAPI-04
HYNIC-FAPI-04 is a useful ligand for making [99mTc]Tc-HYNIC-FAPI-04. In vitro experiments, the results indicated that [99mTc]Tc-HYNIC-FAPI-04 showed binding properties, and inhibited the migration of tumor cells. The…
View activity & pricesDC8026PFK-015
PFK-015 is an effective inhibitor of PFKFB3 with IC50 of 110 nM (recombinant PFKFB3) and inhibits PFKFB3 activity in cancer cells with IC50 of 20 nM.PFK-015 possesses compelling in vitro properties, has satisfactory PK…
View activity & pricesDCAPI1488Temsirolimus
Temsirolimus is an inhibitor of mTOR with an IC50 of 1.76 μM.
View activity & pricesDC7566GW-4064
GW 4064 is a potent FXR agonist with EC50 of 65 nM.
View activity & pricesDC8331GSK2256098
GSK2256098 is a selective FAK kinase inhibitor, which inhibits growth and survival of pancreatic ductal adenocarcinoma cells.
View activity & pricesDC7466MK-5108
MK-5108 inhibits Aurora-A activity in an ATP-competitive manner. MK-5108 shows robust selectivity against the other family kinases Aurora-B (220-fold) and Aurora-C (190-fold) in the biochemical assay. MK-5108 also…
View activity & pricesDC7465MK-2206 2HCl
MK 2206 is an orally active allosteric Akt inhibitor with IC50s of 5, 12 and 65 nM for Akt1, Akt2 and Akt3, respectively.
View activity & pricesDC8522KW-2449
KW-2449 is a multi-targeted kinase inhibitor of FLT3, ABL, ABLT315I and Aurora kinase with IC50s of 6.6, 14, 4 and 48 nM, respectively.
View activity & pricesDC5023Birinapant (TL32711)
Birinapant, a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with Kds of 45 nM and less than 1 nM, respectively.
View activity & pricesDCAPI1490Anidulafungin
Anidulafungin is a new semisynthetic echinocandin with antifungal potency.
View activity & pricesDC11399AVN-492
AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to 5-HT6R (Ki=91 pM).
View activity & pricesDC9704Unii-G55ZH52P57
BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), with MICs of of 2.3 nM and 9.2 nM for M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively.
View activity & pricesDC3111Canagliflozin
Canagliflozin is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively.
View activity & pricesDC3154Fingolimod HCl（FTY-720）
Fingolimod hydrochloride is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells.
View activity & pricesDC7418DNL201
GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM.Invitrogen kinase-selectivity profiling(188 kinases) of…
View activity & pricesDC7308TAK-733
TAK-733 is a potent and selective MEK allosteric site inhibitor with an IC50 of 3.2 nM.
View activity & pricesStructure information available on request
DC8237LRRK2-IN-1
LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 of 6 nM and 13 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.
View activity & pricesDC7284Scriptaid(GCK1026)
Scriptaid is a potent histone deacetylase (HDAC) inhibitor, used in cancer research.
View activity & pricesDC9278CWHM-12
CWHM-12 is a potent inhibitor of αV integrins with IC50s of 0.2, 0.8, 1.5, and 1.8 nM for αvβ8, αvβ3, αvβ6, and αvβ1.
View activity & pricesDC7740ML-324
ML324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity.ML324 is a probe molecule that displays submicromolar inhibitory activity toward JMJD2E (in vitro) and possesses excellent in vitro…
View activity & pricesDC9665EAI045
EAI045 is an allosteric inhibitor of mutant EGFR with IC50s of 1.9, 0.019, 0.19 and 0.002 μM for EGFR, EGFRL858R, EGFRT790M and EGFRL858R/T790M at 10 μM ATP, respectively.
View activity & pricesDC8324CCT244747
CCT244747 is a potent, orally bioavailable and highly selective CHK1 inhibitor, with an IC50 of 7.7 nM; CCT244747 also abrogates G2 checkpoint with an IC50 of 29 nM.
View activity & pricesDC22516Nanvuranlat (JPH203)
JPH203 is a potent and selective L-type amino acid transporter 1 (LAT-1) inhibitor.
View activity & pricesDC7905beta-Lapachone (ARQ-501, CO-501)
Beta-Lapachone inhibits DNA relaxation induced by DNA topoisomerase I in a dose-dependent manner. Treatment of beta-lapachone (100 nM or greater) results in >95% inhibition of Topo I DNA unwinding activity compared to…
View activity & pricesDC8811LJH-685
LJH685 is a potent , specific and selective RSK inhibitor, inhibits RSK1, 2, and 3 biochemical activities with IC50 of 4 to 13 nM.IC50 value: 4 to 13 nM [1]Target: RSKin vitro: LJH685 efficiently inhibits RSK activity…
View activity & pricesDC9253ON123300
ON123300 is a potent inhibitor of CDK4, with an IC50 of 3.8 nM, with little inhibitory activity against CDKs 1,2,5 and 8.
View activity & pricesDC8187Ciraparantag(PER977)
Ciraparantag is a thrombin and factor Xa inhibitors as well as to heparin-based anticoagulants through non-covalent hydrogen bonding and charge interactions. It is reported to antagonize the effects of all coagulants…
View activity & pricesDC90442-Methoxyestradiol
2-Methoxyestradiol is an angiogenesis inhibitor and apoptosis inducer with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules.
View activity & pricesStructure information available on request
DC8330FIIN-2
FIIN-2 is an irreversible inhibitor of FGFR with an IC50 of 3.1, 4.3, 27, and 45 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.
View activity & pricesDC7063Apremilast
Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM.
View activity & pricesDC8563HA130
HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28 nM. IC50 value: 28 nM [2]Target: ATXin vitro: HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM…
View activity & pricesDC8380AZD8186
AZD8186 is a PI3K inhibitor, which potently inhibits PI3Kβ (IC50=4 nM) and PI3Kδ (IC5050=12 nM) with selectivity over PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM).
View activity & pricesDC9784Lu AF21934
Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with an IC50 of 500 nM for human mGlu4.
View activity & pricesDC4217Maraviroc
Maraviroc is a selective CCR5 antagonist with activity against human HIV.
View activity & pricesDC8855Fumagillin
Fumagillin(NSC9168) is a complex biomolecule and used as an antimicrobial agent.Target: AntiparasiticFumagillin is an active amebicide and anti-infective isolated from the fungus Aspergillus fumigatus. Fumagillin does…
View activity & pricesDC8382PF-03084014 (Nirogacestat)
Nirogacestat (PF-3084014) is a reversible, noncompetitive, and selective γ-secretase inhibitor with IC50 of 6.2 nM.
View activity & pricesDC7721RG7090（Basimglurant）
Basimglurant (RG7090) is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM.
View activity & pricesDC7657WH-4-023
WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively; little inhibition on p38α and KDR.
View activity & pricesDC8336Tizoxanide
Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses.
View activity & pricesDC11367PF-04447943
PF-04447943 is a potent inhibitor of human recombinant PDE9A (IC50=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC50>1000 nM).
View activity & pricesDC46844Emraclidine
Emraclidine is a muscarinic M4 receptor positive allosteric modulator (WO2018002760, compound 11). Emraclidine can be used for the research of neurological diseases.
View activity & pricesDC3117Torin2
Torin 2 is an mTOR inhibitor with EC50 of 0.25 nM for inhibiting cellular mTOR activity, and exhibits 800-fold selectivity over PI3K (EC50: 200 nM). Torin 2 also inhibits DNA-PK with an IC50 of 0.5 nM in the cell free…
View activity & pricesDC8741Plerixafor octahydrochloride
Plerixafor octahydrochloride is a selective CXCR4 antagonist with an IC50 of 44 nM.
View activity & pricesDC7716TMP269
TMP269 is a novel and selective class IIa histone deacetylase (HDAC) inhibitor with IC50s of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
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