Isocitrate Dehydrogenase (IDH)

5 products · Page 1 of 1

All small molecule research tools

DC7174

AGI-6780

AGI-6780 that potently and selectively inhibits the tumor-associated mutant IDH2R140Q with IC50 of 23±1.7 nM. AGI-6780 is less potent against IDH2WT with IC50 of 190±8.1 nM.

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DC8374

Enasidenib ( AG-221)

Enasidenib is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K, respectively.

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DC10439

Vorasidenib (AG881)

Vorasidenib is a pan isocitrate dehydrogenase (IDH) inhibitor.

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DC8051

AG-120 (Ivosidenib)

Ivosidenib (AG-120) is a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor with an IC50 of 12 nM for mouse IDH1R132H.

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DC10830

IDH-889

IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and…

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