DC11886Adavivint
Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.
View activity & pricesDC Chemicals · Research reagentsDC11886 
DC7137
DC9841
DC8024
DC5014
DC9715
DC11398
DC5146
DC10380
DC1013
DC10431
DC10779
DC8168
DC8171
DC5165
DC8736
Rheumatoid Arthritis
16 products · Page 1 of 1
All small molecule research tools
DC11886DC7137Filgotinib(GLPG0634)
GLPG0634 is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
View activity & pricesDC9841Fostamatinib(R788)
Fostamatinib (R788), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
View activity & pricesDC8024T-5224
T-5224 is a selective inhibitor of c-Fos/activator protein (AP)-1. It also inhibits MMP3/13 with IC50s of 10 nM.
View activity & pricesDC5014AVL-292
Spebrutinib (AVL-292; CC-292) is a covalent, orally active, and highly selective with an IC50 of 0.5 nM.
View activity & pricesDC9715CHR5154
GSK3117391 (CHR5154) is a HDAC inhibitor.
View activity & pricesDC11398Edicotinib（JNJ-40346527）
Edicotinib（JNJ-40346527）is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS tyrosine kinase inhibitor JNJ-40346527 blocks…
View activity & pricesDC5146RN486
RN486 is a selective Btk inhibitor with an IC50 Value of 4.0 nM.
View activity & pricesDC10380Evobrutinib
Evobrutinib is an inhibitor of Bruton's tyrosin kinase (Btk) inhibitor extracted from patent US20140162983 example 0174.
View activity & pricesDC1013R788 disodium (Fostamatinib)
Fostamatinib Disodium (R788 Disodium), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
View activity & pricesDC10431Upadacitinib
Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor with an IC50 of 43 nM, being developed for the treatment of several autoimmune disorders.
View activity & pricesDC10779PF-06651600
PF-06651600 is a potent JAK3-selective inhibitor with an IC50 of 33.1 nM.
View activity & pricesDC8168Peficitinib（ASP015K,JNJ-54781532）
Peficitinib is an oral JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively.
View activity & pricesDC8171Decernotinib (VX-509,adelatinib)
Decernotinib is a potent, orally active JAK3 inhibitor, with Kis of 2.5, 11, 13 and 11 nM for JAK3, JAK1, JAK2, and TYK2, respectively.
View activity & pricesDC5165Tofacitinib (CP-690550) Citrate
Tofacitinib citrate is a JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively.
View activity & pricesDC8736Tofacitinib
Tofacitinib is a JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively.
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