Edicotinib（JNJ-40346527）

Name: Edicotinib（JNJ-40346527）
Brand: DC Chemicals
SKU: DC11398
Price: 950.0 USD

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TotalUS$950

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Product overview

Description & Application

Edicotinib（JNJ-40346527）is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS tyrosine kinase inhibitor JNJ-40346527 blocks the receptor-ligand interaction between FMS and its ligand CSF1, thereby preventing autophosphorylation of FMS. As a result, unphosphorylated FMS can not activate FMS-mediated signaling pathways, thus potentially inhibiting cell proliferation in FMS-overexpressed tumor cells. FMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation, recruitment, and activation as well as the regulation of cell proliferation.

Parameter	Value
Chemical Name	Edicotinib
CAS No.	1142363-52-7
Synonyms	4-cyano-N-(2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)pyridin-3-yl)- 1H-imidazole-2-carboxamide;4-Cyano-1H-imidazole-2-carboxylic acid N-[2-(4,4-dimethylcyclohex-1-enyl)-6-(2,2,6,6-tetramethyltetrahydropyran-4-yl)pyridin-3-yl]amide;Edicotinib;JNJ40346527;3NU609VYNF;Edicotinib [USAN];Edicotinib (USAN);US8497376, 15;4-cyano-N-[2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyloxan-4-yl)pyridin-3-yl]-1H-imidazole-2-carboxamide;BNVPFDRNGHMRJS-UHFFFAOYSA-N;GTPL8942;BDBM98634;BDBM276743;BCP25086;US10071991, Compound (P);DB12504;AK549463;D11378;Q27893923;4-Cyano-1H-imidazole-2-carboxylic acid N-(2-(4,4-dimet
Formula	C27H35N5O2
M.Wt	461.5991
SMILES	O1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])(C2C([H])=C([H])C(=C(C3=C([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C3([H])[H])N=2)N([H])C(C2=NC([H])=C(C#N)N2[H])=O)C([H])([H])C1(C([H])([H])[H])C([H])([H])[H]
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

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