DC11513Aprocitentan (ACT-132577)
ACT-132577 is the major and pharmacologically active metabolite of macitentan, which is dual ETA/ETB antagonist designed for tissue targeting.
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Small Molecule Research Tools
2816 products · Page 40 of 59
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DC11513DC33859Sulfo-Cy 5 NHS Ester
Sulfo-Cyanine 5 NHS Ester is a water soluble amine reactive red emitting fluorescent dye.Used for the labeling of various amine containing molecules in aqueous phase without use of any organic co-solvent. Useful for…
View activity & pricesDC11451STING agonist compound 1
diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
View activity & pricesDC7242VX-11e(TCS ERK 11e)
VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK with Ki < 2 nM.
View activity & pricesDC32524MTDIA
MTDIA, also known as MT-DADMe-ImmA, and Methylthio-DADMe-Immucillin A, is a MTAP inhibitor. Human 5'-methylthioadenosine phosphorylase (MTAP) is solely responsible for 5'-methylthioadenosine (MTA) metabolism to permit…
View activity & pricesDC20945DC_AC50
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance[1].
View activity & pricesDC45287TRPC6-PAM-C20
TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. TRPC6-PAM-C20 selectively activates TRPC6 over other TRP channels and also activates TRPA1. TRPC6-PAM-C20 induces transient increase in intracellular…
View activity & pricesDC48721Biotin-aniline
Biotin-aniline is a probe with substantially high reactivity towards RNA and DNA. Biotin-aniline emerges as more efficient probe for capturing subcellular transcriptome in living cells with high spatial specificity.
View activity & pricesDC8265Endoxifen
Endoxifen Z-isomer is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα). Endoxifen inhibits hERG…
View activity & pricesDC48369AGB1
AGB1 is a fast, highly selective, and potent bump-and-hole (B&H)-PROTAC degrader for BromoTag. AGB1 exhibits degradation for Ab:Brd4BD2 L387A and Ab: BromoTag-Brd2 with pDC50s of 7.8 and 7.9. AGB1 exhibits binary…
View activity & pricesDC8464Rucaparib(AG-014447)
Rucaparib is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, and also shows binding affinity to eight other PARP domains.
View activity & pricesDC33611PSMA-617 Linker
Vipivotide tetraxetan Ligand-Linker Conjugate (PSMA-617 Ligand-Linker Conjugate) is composed of a linker and Glutamate-urea-Lysine, can be used to synthesize Vipivotide tetraxetan (PSMA-617). Glutamate-urea-Lysine is…
View activity & pricesDC31239NSC729477
Exherin, also known as ADH-1, is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin,…
View activity & pricesDC60460SJ3149
SJ3149 is a uniquely potent and selective CK1α degrader with DC50 of 3.7 nM. SJ3149 shows high activity across a range of acute leukemia (AL) cell lines derived from different hematologic neoplasms, such as B-cell and…
View activity & pricesDC46193BRM/BRG1 ATP Inhibitor-1
BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4…
View activity & pricesDC38000Leupeptin
Leupeptin is a protease inhibitor, will strongly inhibit Trypsin, Papain, Plasmin, Thrombokinase, Kallikrein and Cathepsin B. The half-maximal inhibitory concentration ranges from 0.5 to 75 μg/ml, depending on the…
View activity & pricesDC65679BI-2493
BI-2493 is a structural analogue of BI-2865 and a highly selective pan-KRAS inhibitor. BI-2493 can attenuate tumor growth. BI-2493 can be used for cancer iseases research.
View activity & pricesDC65676Fenretinide Glucuronide Monosodium Salt
Fenretinide Glucuronide Monosodium Salt, is the metabolite of Fenretinide (F250000), which is a synthetic retinoid deriverative, substances related to vitamin A. They are also shown to be used for the treatment of…
View activity & pricesDC22826Suramin sodium salt
Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity; inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34; induces…
View activity & pricesDC9679BAY1217389
BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM.
View activity & pricesDC34025AkaLumine
AkaLumine is a luciferin analogue. The bioluminescence produced by AkaLumine in reactions with native firefly luciferase is in the near-infrared wavelength ranges (λmax=677?nm), and yields significantly increased…
View activity & pricesDC23522Aplaviroc HCl
Aplaviroc, also known as AK-602; GW-873140; GW873140A; ONO-4128, is a CCR5 entry inhibitor for the potential treatment of HIV infection. Aplaviroc (GW873140) binds specifically to human cellular CC chemokine receptor 5…
View activity & pricesDC21570Azvudine
Azvudine (RO 0622) is a potent HCV NS5B RNA polymerase inhibitor, inhibits HCV replication in the replicon system with IC50 of 24 nM; inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or…
View activity & pricesDC44905Vepdegestrant (ARV-471)
ARV-471 is a best-in-class, orally active estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.
View activity & pricesDC21105H3B-8800
H3B-8800 is an orally available splicing modulator that targets spliceosome SF3b complex containing either WT or mutant SF3B1 (binding IC50 of 0.3-2 nM); demonstrates dose-dependent inhibition of both canonical…
View activity & pricesDC65502BI-2865
BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 blocked nucleotide exchange to prevent the activation of wild-type KRAS and a broad range of KRAS mutants, including G12A/C/D/F/V/S, G13C/D, V14I, L19F, Q22K,…
View activity & pricesDC21584MIN-101
MIN-101 (Roluperidone, CYR-101, MT-210) is a higly potent 5-HT2A and sigma 2 receptor antagonist, with no direct dopamine affinities, for treatment of negative symptoms in schizophrenia. Schizophrenia Phase 3 Clinical
View activity & pricesDC60219Camibirstat (FHD-286)
FHD-286 is a BRG1/BRM ATPase inhibitor for the treatment of BAF-related disorders such as acute myeloid leukemia.
View activity & pricesDC3156Elesclomol (STA-4783)
Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis.
View activity & pricesDC9717amyloid P-IN-1(GSK3039294)
pharmaceutical compositions comprising the same and the use of the same for treatment of diseases or disorders wherein depletion of serum amyloid P component (SAP) would be beneficial, including amyloidosis,…
View activity & pricesDC21821Perhexiline maleate
Perhexiline maleate is a potent carnitine palmitoyltransferase 1 (CPT 1) inhibitor with IC50s of 77 and 148 μM for rat heart and liver CPT 1, respectively.
View activity & pricesDC7913SB225002
SB225002 is a potent and selective CXCR2 antagonist with an IC50 of 22 nM.
View activity & pricesDC10153GDC-0077
GDC-0077 is an orally available PI3K inhibitor with potential antineoplastic activity. GDC-0077 is extracted from patent WO 2017001645 A1, formula I.
View activity & pricesDC4198Epothilone B
Epothilone B is a microtubule stabilizer with a Ki of 0.71μM. It acts by binding to the αβ-tubulin heterodimer subunit which causes decreasing of αβ-tubulin dissociation.
View activity & pricesDC65521PTC-258 2HCl
PTC-258 2HCl is a specific and orally active splicing modulator of Elongator complex protein 1 gene (ELP1). PTC258 increases the expression of ELP1 in vitro and in vivo. PTC258 is well tolerated in mouse model.
View activity & pricesDC7410Erastin
Erastin is a ferroptosis activator.
View activity & pricesDC9651Ingenol 3-angelate
Ingenol 3-Angelate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has…
View activity & pricesDCL-072Vinblastine sulfate
For the detailed information of Vinblastine sulfate, the solubility of Vinblastine sulfate in water, the solubility of Vinblastine sulfate in DMSO, the solubility of Vinblastine sulfate in PBS buffer, the animal…
View activity & pricesDC50008Colchicine
Colchicine is a potent therapeutic tool against COVID-19. Colchicine is a tricyclic alkaloid that is extracted from the plant Colchicum autumnale. Colchicine acts as a potent inhibitor of tubulin polymerization.
View activity & pricesDC47470SBP-3264
SBP-3264 (SBP3264) is a sepecific inhibitor of Hippo signaling pathway kinases STK3 and STK4 with low nanomolar potency. SBP-3264 specifically inhibited the Hippo signaling pathway in cultured mammalian cells and…
View activity & pricesDC65841MC1
MC1 is a selective and potent COX-2 inhibitor, and its radiolabeled form, ¹¹CMC1, is a promising PET radiotracer for detecting COX-2 expression in vivo. Its ability to visualize COX-2 in neuroinflammation and other…
View activity & pricesDC8688Leupeptin hemisulfate
Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor, which has been shown to inhibit cathepsins B, H, L, and S, calpain, and trypsin. Leupeptin hemisulfate is an orally active,…
View activity & pricesDC72663SW222746
SW222746 (SW 222746) is a potent selective, orally active inhibitor of 15-Prostaglandin dehydrogenase (15-PGDH) with IC50 of 3 nM.
View activity & pricesDC65839MC1 Precursor
Precursor of MC1, is a vital component in the synthesis of MC1, a selective and potent COX-2 inhibitor. Radiolabeled MC1, ¹¹CMC1, serves as a promising PET radioligand for imaging COX-2 expression in vivo. Its high…
View activity & pricesDC60535NT-0796
NT-0796 is a Brain-Penetrant and Highly Potent. NLRP3 Inflammasome Inhibitor (IC50 = 0.32 nM) for Neuroinflammatory Disorders.
View activity & pricesDC70046MRTX 0902
MRTX0902 is a potent SOS1 inhibitor with an IC50 of 46 nM (WO2021127429A1; Example 12-10).
View activity & pricesDC70840TH9619
TH9619 (TH-9619) is a potent and selective inhibitor of folate metabolism enzyme MTHFD2 with IC50 of 47 nM.TH9619 demonstrated efficacy on HL-60 cell viability with EC50 of 11 nM.TH9619 potently inhibits related MTHFD…
View activity & pricesDC60646GSDMD agonist DMB (C-185)
DMB(C-185) is a direct and selective GSDMD agonist that activates GSDMD pore formation and pyroptosis without cleaving GSDMD. DMB treatment synergizes with anti-PD-1 and does not alter circulating proinflammatory…
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