DC9713GSK2981278
GSK2981278 is a retinoid-related orphan receptor gamma (RORy) modulator, extracted from patent WO/2015061515 A1, example 124.
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Small Molecule Research Tools
2816 products · Page 15 of 59
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DC9713DC8447KC7F2
KC7F2 is a potent HIF-1 pathway inhibitor and that its potential as a cancer therapy agent warrants further study.Target：HIFin vitro: KC7F2 is the second HIF-1α inhibitor. KC7F2 is shown to inhibit the proliferation of…
View activity & pricesDC8972Carmustine
Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.
View activity & pricesDC8454Nutlin-3a
Nutlin 3a is an active enantiomer of Nutlin-3, acts as a murine double minute (MDM2) antagonist that inhibits MDM2-p53 interactions and stabilizes the p53 protein, and thereby induces cell cycle arrest and apoptosis.
View activity & pricesDC7176Quisinostat (JNJ-26481585) 2HCl
Quisinostat (JNJ-26481585) is an orally available, potent HDAC inhibitor with an IC50 of 0.11 nM for HDAC1.
View activity & pricesDC9737SHP099 hydrochloride
SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC50 of 70 nM.
View activity & pricesDCAPI1021Cidofovir(Vistide)
Cidofovir is an anti-CMV drug which can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription.
View activity & pricesDC60225AOD-9604
AOD-9604 is a potential anti-obesity peptide based on human growth hormone. AOD9604 was originally developed after research on mice, but subsequent studies in human have shown no efficacy for the potential treatment of…
View activity & pricesDC2016MLN8237 (Alisertib)
Alisertib (MLN 8237) is a selective Aurora A inhibitor with an IC50 of 1.2 nM.
View activity & pricesDC10832(E/Z)-4-hydroxy Tamoxifen
(E/Z)-4-Hydroxytamoxifen is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is an estrogen receptor modulator.
View activity & pricesDC1071Vemurafenib (PLX4032)
Vemurafenib is a novel and potent inhibitor of B-RAF kinase, with IC50s of 31 and 48 nM for RAFV600E and c-RAF-1, respectively.
View activity & pricesDC8134Trichostatin A (TSA)
Trichostatin A is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC.
View activity & pricesDC9764Afoxolaner
Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA &…
View activity & pricesDC39262SBP-7455
SBP-7455 is an orally active dual-specific ULK1/2 autophagy inhibitor with improved binding affinity compared with SBI-0206965.
View activity & pricesDC22989BMS-204493
BMS-204493(BMS493) is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation[1][2].
View activity & pricesDC9303Taprenepag(CP-544326)
CP-544326 is a potent and selective prostaglandin E2 receptor agonist with an EC50 of 2.8 nM.
View activity & pricesDC7815Crisaborole(AN-2728)
AN-2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines. AN-2728 appears to have…
View activity & pricesDC2070GSK690693
GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2/13/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes.
View activity & pricesDC7694BAF312 (Siponimod)
Siponimod (BAF-312) is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. It is selective for S1P1 and S1P5 receptors over S1P2, S1P3, and S1P4 (EC50s of 0.39, 0.98, >10,000, >1,000, and 750 nM,…
View activity & pricesDC12023dBET1
dBET1 is a potent BRD4 protein degrader based on PROTAC technology with an EC50 of 430 nM.
View activity & pricesDC11360Pemafibrate
Pemafibrate is a potent PPARα agonist, with EC50s of 1 nM, 1.10 μM and 1.58 μM for h-PPARα, h-PPARγ and h-PPARδ, respectively, and possesses lipid-lowering effect.
View activity & pricesDC3112AS-252424
AS-252424 is a potent and selective PI3Kγ inhibitor with an IC50 of 30±10 nM.
View activity & pricesDC5027ABC294640（Opaganib）
Opaganib (ABC294640) is a selective, competitive sphingosine kinase 2 (SK2) inhibitor with Ki of 9.8 μM.
View activity & pricesDC9783Bay 59-3074
Bay 59-3074 is a novel, selective CB1/CB2 receptor partial agonist with Ki values of 48.3 and 45.5 nM at human CB1 and CB2 receptors respectively . Orally active CB1 agonist in vivo.
View activity & pricesDC6312SB525334
SB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC50 of 14.3 nM.
View activity & pricesDC1010BIBR-1048 (Dabigatran etexilate)
Dabigatran etexilate(BIBR-1048) is the orally active prodrug of dabigatran; Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM.
View activity & pricesDC2096AG490
AG-490 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
View activity & pricesDC7589Eniporide(EMD96785)
Eniporide is a The Na(+)/H(+) exchange inhibitor.
View activity & pricesDC7656Ro 61-8048
Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with IC50 of 37 nM.
View activity & pricesDC10895E260
E260 is a Fer/FerT kinase inhibitor.
View activity & pricesDC8327SANT-1
SANT-1 is a potent Smo antagonist, inhibits Hedgehog signaling, with IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively[1].
View activity & pricesDC7544CUDC-101
CUDC-101 is a potent inhibitor of HDAC, EGFR, and HER2 with IC50s of 4.4, 2.4, and 15.7 nM, respectively.
View activity & pricesDC10647EPZ015938(pemrametostat)
GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM.
View activity & pricesDC7373Betrixaban
Betrixaban is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with IC50 of 1.5 nM.
View activity & pricesDC8457BMS-309403
BMS-309403 is a potent, selective and cell-permeable inhibitor of fatty acid binding protein 4 (FABP4) with a Ki of less than 2 nM.
View activity & pricesDC26154LIT927
LIT-927 is a locally and orally active CXCL12 neutraligand with anti-inflammatory effect, with a Ki of 267 nM for CXCL12-TR binding.
View activity & pricesDC4128Ivacaftor (VX-770)
Ivacaftor is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively.
View activity & pricesDC9576Niraparib tosylate
Niraparib tosylate (MK-4827 tosylate) is an excellent PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively.
View activity & pricesDC5022XL019
XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1; shows good biochemical and cellular potency against JAK2 with good selectivity against the Janus Kinase family as well…
View activity & pricesDC9760Dihexa (PNB-0408)
Dihexa is an orally active, blood-brain barrier-permeable angiotensin IV analog; exhibits high affinity binding hepatocyte growth factor (HGF) with a Kd of 65 pM.
View activity & pricesDC9248Olodaterol(BI-1744) hydrochloride
Olodaterol (BI1744) hydrochloride is a selective, long acting β2-adrenoceptor (β2-AR) agonist (EC50=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive…
View activity & pricesDC7835H-89 2HCl
H-89 dihydrochloride is a potent inhibitor of protein kinase A (PKA) with an IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase.
View activity & pricesDC5049RAF265 (CHIR-265)
RAF265 is a potent RAF/VEGFR2 inhibitor.
View activity & pricesDC8592Sivelestat (sodium salt hydrate)
Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.ONO-5046 did not…
View activity & pricesDC12637Finerenone
Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid…
View activity & pricesDC2018LY335979 (Zosuquidar 3HCl)
Zosuquidar trihydrochloride is an inhibitor of P-glycoprotein with a Ki value of 59 nM.
View activity & pricesDC26030CCMI
CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7…
View activity & pricesDC8179Briciclib(ON 013105,ON 014185)
Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers.
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