BAF312 (Siponimod) chemical structure
Chemical structureResearch use only
CAT. NO. DC7694Featured

BAF312 (Siponimod)

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Product overview

Description & Application

Siponimod (BAF-312) is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. It is selective for S1P1 and S1P5 receptors over S1P2, S1P3, and S1P4 (EC50s of 0.39, 0.98, >10,000, >1,000, and 750 nM, respectively.)

ParameterValue
Chemical NameSiponimod
CAS No.1230487-00-9
SynonymsBAF-312(SiponiMod);1-(4-[1-[(E)-4-Cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl]-2-ethyl-benzyl)-azetidine-3-carboxylic acid;BAF 312;Siponimod;BAF312 (Siponimod);BAF312;RR6P8L282I;Siponimod [INN];3-Azetidinecarboxylic acid, 1-((4-((1E)-1-(((4-cyclohexyl-3-(trifluoromethyl)phenyl)methoxy)imino)ethyl)-2-ethylphenyl)methyl)-;1-[[4-[(E)-N-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-C-methylcarbonimidoyl]-2-ethylphenyl]methyl]azetidine-3-carboxylic acid;Siponimod [WHO-DD];3-Azetidinecarboxylic acid, 1-[[4-[(1E)-1-[[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino]ethyl]
FormulaC29H35F3N2O3
M.Wt516.6
SMILESFC(C1C([H])=C(C([H])([H])O/N=C(\C([H])([H])[H])/C2C([H])=C([H])C(=C(C=2[H])C([H])([H])C([H])([H])[H])C([H])([H])N2C([H])([H])C([H])(C(=O)O[H])C2([H])[H])C([H])=C([H])C=1C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(F)F
Purity>98%
Storage2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Biological Activity

Siponimod (BAF-312) is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. It is selective for S1P1 and S1P5 receptors over S1P2, S1P3, and S1P4 (EC50s of 0.39, 0.98, >10,000, >1,000, and 750 nM, respectively.)

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

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References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

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