Heat Shock Protein (HSP)

15 products · Page 1 of 1

All small molecule research tools

DC9948

SNX-5422(PF04929113)

SNX-5422 (PF-04929113), a prodrug of SNX-2112, is an orally active Hsp90 inhibitor, with a Kd of 41 nM, and also induces Her-2 degradation, with an IC50 of 37 nM.

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DC8167

Onalespib（AT13387,ATI13387X）

AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. in vitro: AT13387 is a synthetic, orally bioavailable, small-molecule inhibitor of heat…

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DC6307

XL888

XL888 is a heat shock protein-90 (HSP90) inhibitor, with an IC50 of 24 nM.

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DC8299

VER155008

VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 μM for Hsp70.

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DC4178

NVP-HSP990 (HSP990)

NVP-HSP990 is a potent and selective Hsp90 inhibitor, with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively.

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DC5202

Luminespib (NVP-AUY922)

Luminespib (NVP-AUY922) is a potent HSP90 inhibitor with IC50s of 7.8 and 21 nM for HSP90α and HSP90β, respectively.

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DC7320

Ganetespib(STA-9090)

Ganetespib is a heat shock protein 90 (HSP90) inhibitor which exhibits potent cytotoxicity in a wide variety of hematological and solid tumor cell lines.

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DC9994

ML-346

ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC50 of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity.…

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DC7390

CUDC-305(DEBIO 0932)

Debio 0932 is an orally active HSP90 inhibitor, with IC50s of 100 and 103 nM for HSP90α and HSP90β, respectively.

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DC8247

KNK437

KNK437 is a HSP inhibitor, and inhibits the induction of HSP105, HSP70, and HSP40.

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DC8142

TAS-116

TAS-116 is a potent and selective HSP90α/β inhibitor with Kis of 34.7 nM, 21.3 nM, respectively.

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DC10498

CCT251236

CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction.

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DC9482

17-AAG

17-AAG is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90.

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DC7806

Geldanamycin (NSC122750)

Geldanamycin binds in the ATP-binding site in the N-terminus domain of Hsp90s (residues 1-220). Geldanamycin inhibits the ATPase activity of Hsp90 in a dose-dependent manner. Geldanamycin causes a dose-dependent G2…

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DC70417

Foldamer 33

Foldamer 33 is a small molecule HSP110 inhibitor, directly binds to the nucleotide-binding domain (NBD) of HSP110, blocks HSP110 chaperone function and colorectal cancer growth.Foldamer 33 significantly inhibit HSP110…

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