Geldanamycin (NSC122750) chemical structure
Chemical structureResearch use only
CAT. NO. DC7806Featured

Geldanamycin (NSC122750)

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Product overview

Description & Application

Geldanamycin binds in the ATP-binding site in the N-terminus domain of Hsp90s (residues 1-220). Geldanamycin inhibits the ATPase activity of Hsp90 in a dose-dependent manner. Geldanamycin causes a dose-dependent G2 arrest and reversible inhibiton o f entry into the S phase in A2780 human ovarian cell line. This inhibition is accompanied by p53 increase and finally demonstrated to be p53 dependent. Geldanamycin causes polyubiquitination and proteasomal degradation of the p185 receptor protein-tyrosin kinase and shows a IC50 with 70 nM. [3, 4] Geldanamycin is a typical anti-tumor reagent, shows a mean GI50 with 0.18 μM against the panel of 60 human tumor cell lines. [5] Geldanamycin (50 mg//kg) shows 30% inhibition on pl85-associated phosphotyrosine levels in FRE/erbB-2 mice. [6]. For the detailed information of Geldanamycin (NSC122750), the solubility of Geldanamycin (NSC122750) in water, the solubility of Geldanamycin (NSC122750) in DMSO, the solubility of Geldanamycin (NSC122750) in PBS buffer, the animal experiment (test) of Geldanamycin (NSC122750), the cell expriment (test) of Geldanamycin (NSC122750), the in vivo, in vitro and clinical trial test of Geldanamycin (NSC122750), the EC50, IC50,and affinity,of Geldanamycin (NSC122750), Please contact DC Chemicals.

ParameterValue
Chemical NameGeldanamycin
CAS No.30562-34-6
SynonymsGeldanamycin;GeldanamyCln;Geldanamycin from Streptomyces hygroscopicus;Geldanamycin (Geldanomycin,U-29135, NSC 122750);GeldanaMycin, froM StreptoMyces hygroscopicus var geldanus;GELDANAMYCIN FROM STRE;GELDANAMYCIN,STREPTOMYCES HYGROSCOPICUS;Streptomyces hygroscopicus;[(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate;CCG-208040;HMS1990E15;2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-[(aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, [8S-(4E,6Z,8R*,9R*,10E,12R*,13S*,14R*,16S*)]-;SCHEMBL4154;GTPL9829;U-29135;HMS1792E15;GELDANAMYCIN [MI];BRN 1633093;BSPBio_001073;G0334;GMY;NSC 122750;NCGC00163449-02;MFCD00274570;geldanamycin;HMS3403E15;Geldanamycin from Streptomyces hygroscopicus, >=98% (HPLC), powder;SR-05000002266-3;[8S-(4E,6Z,8R*,9R*,10E,12R*,13S*,14R*,16S*)]-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione;SCHEMBL13037476;QTQAWLPCGQOSGP-KSRBKZBZSA-N;Geldanamycin, Streptomyces hygroscopicus - CAS 30562-34-6;GDM;[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate;2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-[(aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-;[(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate;HMS1362E15;EI-280;U 29135;(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate;DB02424;Z2568648438;1yet;[(3S,5S,6R,7S,8E,10R,11S,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-8,12,14,18,21-pentaen-10-yl] carbamate;BDBM50008059;Geldanamycin (9CI);Z3K3VJ16KU;SR-05000002266;2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate (8CI);UNII-Z3K3VJ16KU;IDI1_002122;NSC-122750;CHEBI:91381;BRD-K11528507-001-01-8;NCGC00163449-01;CHEBI:5292;NS00011696;J-018017;AKOS024456552;J-521410;DTXSID7042691;30562-34-6;A1-50253;2-Azabicyclo[16.3.1]docosa-4,10,18,21-pentaene- 3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy- 4,10,12,16-tetramethyl-, 9-carbamate;2-Azabicyclo[16.3.1]docosa-4,10,18,21-pentaene- 3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy- 4,10,12,16-tetramethyl-, 9-carbamate;Antibiotic U 29135;Antibiotic U 29135;NSC122750;NSC122750;CHEMBL182055;CHEMBL182055;Antibiotic (U-29,135);Antibiotic (U-29,135);Geldanamicin;Gel...
FormulaC29H40N2O9
M.Wt560.6359
SMILESCOC(C(C=C1NC(/C(C)=C/C=C/[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H]2O)=O)=O)=C(C[C@H](C[C@@H]2OC)C)C1=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Geldanamycin binds in the ATP-binding site in the N-terminus domain of Hsp90s (residues 1-220). Geldanamycin inhibits the ATPase activity of Hsp90 in a dose-dependent manner. Geldanamycin causes a dose-dependent G2 arrest and reversible inhibiton o f entry into the S phase in A2780 human ovarian cell line. This inhibition is accompanied by p53 increase and finally demonstrated to be p53 dependent. Geldanamycin causes polyubiquitination and proteasomal degradation of the p185 receptor protein-tyrosin kinase and shows a IC50 with 70 nM. [3, 4] Geldanamycin is a typical anti-tumor reagent, shows a mean GI50 with 0.18 μM against the panel of 60 human tumor cell lines. [5] Geldanamycin (50 mg//kg) shows 30% inhibition on pl85-associated phosphotyrosine levels in FRE/erbB-2 mice. [6]. For the detailed information of Geldanamycin (NSC122750), the solubility of Geldanamycin (NSC122750) in water, the solubility of Geldanamycin (NSC122750) in DMSO, the solubility of Geldanamycin (NSC122750) in PBS buffer, the animal experiment (test) of Geldanamycin (NSC122750), the cell expriment (test) of Geldanamycin (NSC122750), the in vivo, in vitro and clinical trial test of Geldanamycin (NSC122750), the EC50, IC50,and affinity,of Geldanamycin (NSC122750), Please contact DC Chemicals.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Refer to the certificate supplied with your lot for batch-specific release results.

Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

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