DC Chemicals · Research reagents

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Cytarabine hydrochloride chemical structureDCAPI1566

Cytarabine hydrochloride

For the detailed information of Cytarabine hydrochloride, the solubility of Cytarabine hydrochloride in water, the solubility of Cytarabine hydrochloride in DMSO, the solubility of Cytarabine hydrochloride in PBS…

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5-Fluorouracil chemical structureDC8944

5-Fluorouracil

5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools.5-Fluorouracil is metabolized to ribonucleotides and…

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Thalidomide chemical structureDC9009

Thalidomide

Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo.Thalidomide was commonly used therapeutically in the late 1950's; however, it was withdrawn from the market when it was discovered to cause…

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Tex Red-X Acid chemical structureDC67959

Tex Red-X Acid

Tex Red-X dye is an innovative alternative to Tex Red. A key difference lies in its chemical structure - it features an additional seven - atom aminocaproyl spacer ("X") between the fluorophore and the carboxyl group.…

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Trpm2 Inhibitor A23 chemical structureDCC5248

Trpm2 Inhibitor A23

Novel selective inhibitor of the transient receptor potential melastatin 2 (TRPM2) channel, exhibiting TRPM2 selectivity over TRPM8 and TRPV1 channels as well as phospholipase A2 and showing neuroprotective activity in…

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AH001 chemical structureDC78346

AH001

AH001 is a orally active RhoA inhibitor, which binds a cryptic pocket proximate to GDP within RhoA with a KD of 73.16 nM. AH001 interacts with GDP, stabilizing RhoA’s interaction with its endogenous inhibitor, RhoGDIα.…

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Trilostane(Win 24540; Modrastane) chemical structureDC8629

Trilostane(Win 24540; Modrastane)

Trilostane(Win 24540; Modrastane) is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome.Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase (3-β-HSD or delta 5-delta…

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YTHDC1 inhibitor 40 (compound 40) chemical structureDC60707

YTHDC1 inhibitor 40 (compound 40)

YTHDC1 inhibitor 40 is a potent, selective m6A reader YTHDC1 inhibitor with ITC Kd of 49 nM, HTRF IC50 of 0.35 uM. Compound 40 shows antiproliferative activity against the acute myeloid leukemia (AML) cell lines THP-1,…

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Sutezolid (PNU-100480) chemical structureDC10733

Sutezolid (PNU-100480)

Sutezolid (PNU-100480) is an oxazolidinone antimicrobial being developed for the treatment of tuberculosis.Target: AntibacterialSutezolid is a much-awaited drug candidate for treatment of Mycobacterium tuberculosis.…

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Val-Cit-PAB-MMAF chemical structureDC71665

Val-Cit-PAB-MMAF

Val-Cit-PAB-MMAF is a drug-linker conjugate for ADC. Val-Cit-PAB-MMAF contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin polymerization inhibitor MMAF.

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DOCK5-IN-C21 chemical structureDC34489

DOCK5-IN-C21

DOCK5-IN-C21 functions as an allosteric inhibitor targeting the guanine nucleotide exchange factor DOCK5, effectively modulating its activity through a non-competitive mechanism.

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FL-1607 chemical structureDC74445

FL-1607

FL-1607, a novel Fam20C inhibitor, has shown remarkable anti-proliferative effects in triple-negative breast cancer (TNBC) cells. This compound induces apoptosis and significantly reduces the migration ability of…

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Indacaterol chemical structureDC8914

Indacaterol

Indacaterol is a potent, orally administered ultra-long-acting β2 adrenergic receptor (ADRB2) agonist, widely recognized for its therapeutic potential in respiratory and cardiovascular conditions. By selectively…

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Idoxuridine chemical structureDC31184

Idoxuridine

Idoxuridine is an anti-herpesvirus antiviral and anticancer drug. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to…

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Disodium (R)-2-Hydroxyglutarate chemical structureDC8385

Disodium (R)-2-Hydroxyglutarate

D-alpha-Hydroxyglutaric acid disodium salt is a weak competitive α-Ketoglutarate(α-KG)-dependent dioxygenase inhibitor with Ki of 10.87±1.85 mM. Ki for L-Hydroxyglutaric acid (L-2-HG) is 0.628±0.036 mM.

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Fluorocholine chloride chemical structureDC67510

Fluorocholine chloride

Fluorocholine chloride serves as a versatile biochemical tool for life science investigations, functioning both as an organic compound and biological marker in various research applications.

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SNC-80 chemical structureDC22902

SNC-80

SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a Ki of 1.78 nM and an IC50 of 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8…

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PI-2620 precursor chemical structureDC67437

PI-2620 precursor

PI-2620 precursor is the precursor of PI2620. 18F-PI-2620 is a PET tracer with high binding affinity for aggregated tau, a key pathologic feature of Alzheimer disease (AD) and other neurodegenerative disorders.

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Lycorine hydrochloride chemical structureDCY-118

Lycorine hydrochloride

For the detailed information of Lycorine hydrochloride, the solubility of Lycorine hydrochloride in water, the solubility of Lycorine hydrochloride in DMSO, the solubility of Lycorine hydrochloride in PBS buffer, the…

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Desmopressin (Acetate) chemical structureDC9637

Desmopressin (Acetate)

Desmopressin(DDAVP) acetate is the synthetic analogue of the antidiuretic hormone arginine vasopressin. IC50 Value:Target: Vasopressin ReceptorThe antidiuretic properties of desmopressin have led to its use in polyuric…

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LM10 chemical structureDC48542

LM10

LM10 is a potent inhibitor of tryptophan 2,3-dioxygenase (TDO). Tryptophan 2,3-dioxygenase (TDO) is an unrelated hepatic enzyme that also degrades tryptophan along the kynurenine pathway. LM10 has the potential for the…

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LY2880070 chemical structureDC74584

LY2880070

LY2880070 is an orally active inhibitor of CHK1. LY2880070 can be used as an anticancer agent and shows promise in preclinical models of pancreatic ductal adenocarcinoma (PDAC) when used in combination with…

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PAA-38 HCl chemical structureDC68137

PAA-38 HCl

PAA-38 is a highly potent selective inhibitor targeting bacterial prolyl-tRNA synthetase (ProRS). PAA-38 againsts Pseudomonas aeruginosa ProRS (PaProRS) with a Kd value of 0.399 nM and an IC50 value of 4.97 nM. PAA-38…

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Peptide T7 with N-Cysteine chemical structureDC67516

Peptide T7 with N-Cysteine

This study developed CRD-PEG-T7, a prostate cancer-targeting gene delivery system featuring a disulfide-crosslinked arginine-aspartic acid peptide vector modified with T7 targeting ligands for selective pDNA delivery…

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Hydroxyurea (Cytodrox) chemical structureDCAPI1045

Hydroxyurea (Cytodrox)

For the detailed information of Hydroxyurea (Cytodrox), the solubility of Hydroxyurea (Cytodrox) in water, the solubility of Hydroxyurea (Cytodrox) in DMSO, the solubility of Hydroxyurea (Cytodrox) in PBS buffer, the…

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Motixafortide(BKT140) chemical structureDC10423

Motixafortide(BKT140)

BKT140 4-fluorobenzoyl is a novel CXCR4 antagonist with an IC50 vakue of ~1 nM. Sequence: 4F-Benzoyl-Arg-Arg-{2-Naph-Ala}-Cys-Tyr-{Cit}-Lys-Lys-Pro-Tyr-Arg-{Cit}-Cys-Arg-NH2(Disulfide bridge: Cys4-Cys13).

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Mifepristone (RU486) chemical structureDC31256

Mifepristone (RU486)

Mifepristone (RU-486) is a potent steroidal antagonist exhibiting subnanomolar affinity for progesterone receptors (PR IC₅₀ = 0.2 nM) and nanomolar activity against glucocorticoid receptors (GR IC₅₀ = 2.6 nM). This…

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Savirin chemical structureDC72952

Savirin

Savirin (S. aureus virulence inhibitor) is a small molecule that targets the agr (accessory gene regulator) quorum sensing system in Staphylococcus aureus (S. aureus). The agr system is a key regulatory pathway that…

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Foxy-5(Wnt5a peptide mimetic) chemical structureDC23893

Foxy-5(Wnt5a peptide mimetic)

Foxy-5 is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 is a WNT5A agonist and effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic…

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Leuprorelin chemical structureDC22504

Leuprorelin

Leuprolide is an agonist at pituitary GnRH receptors. Target: GnRH receptorLeuprorelin is a gonadotrophin-releasing hormone (GnRH) analogue used to treat a wide range of sex hormone-related disorders including advanced…

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MOTS-c chemical structureDC71255

MOTS-c

MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway.

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Semax chemical structureDC26045

Semax

Semax is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) (4-10) that has neuroprotective, analgesic, and anxiolytic properties.In vivo, semax (0.3 mg/kg) reduces cortical nitric oxide (NO) production…

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Quercetin chemical structureDCH-009

Quercetin

For the detailed information of Quercetin, the solubility of Quercetin in water, the solubility of Quercetin in DMSO, the solubility of Quercetin in PBS buffer, the animal experiment(test) (test) of Quercetin, the cell…

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LY3502970 (Orforglipron) chemical structureDC70577

LY3502970 (Orforglipron)

LY-3502970 (Orforglipron) is a potent, selective, orally active non-peptide agonist of glucagon-like peptide-1 (GLP-1) receptor.LY3502970 is a partial agonist, biased toward G protein activation over β-arrestin…

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Elacridar hydrochloride chemical structureDC22621

Elacridar hydrochloride

Elacridar Hcl (GF120918; GW0918) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of…

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Lorcaserin chemical structureDC1011

Lorcaserin

LLorcaserin (APD-356)is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic

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