Endothelin Receptor

5 products · Page 1 of 1

All small molecule research tools

DC4108

Sitaxentan sodium

Sitaxsentan (sodium) is an orally active, highly selective antagonist of endothelin A receptors.

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DC8191

Sparsentan(PS433540)

Sparsentan (RE-021; BMS-346567; PS433540; DARA-a) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively.

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DC11513

Aprocitentan (ACT-132577)

ACT-132577 is the major and pharmacologically active metabolite of macitentan, which is dual ETA/ETB antagonist designed for tissue targeting.

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DC8392

BQ-123

BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) . 1) Reduces ischemia-induced ventricular arrhythmias in a rat model.2) BQ-123 prevents LPS-induced…

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DC1012

Macitentan (Actelion-1,ACT-064992)

Macitentan is an orally active, non-peptide endothelin receptor antagonist for the treatment of idiopathic pulmonary fibrosis and pulmonary arterial hypertension.

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