DC12037Triptolide
Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory and antiproliferative effects. Triptolide is a NF-κB activation inhibitor.
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Small Molecule Research Tools
2816 products · Page 25 of 59
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DC12037DC7160SGI-1776
SGI-1776 is an inhibitor of Pim kinases, with IC50s of 7 nM, 363 nM, and 69 nM for Pim-1, -2 and -3, respectively.
View activity & pricesDC70509IMP-1710
IMP-1710 (IMP1710) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 38 nM.IMP-1710 demonstrated exquisite selectivity in a cross-screening against 20 DUBs.IMP-1710 can profile activity of endogenous UCHL1…
View activity & pricesDC8373GSK8573
GSK8573 (compound 23) is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 with a Kd value of 1.04 μM and is inactive against BAZ2A/B and other bromodomain familiy[1].
View activity & pricesDC20219D159687
D159687 is a selective PDE4D inhibitor[1].
View activity & pricesDC8846HhAntag
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway; antitumor agent.IC50 value:Target: Gli
View activity & pricesDC22313PS48
PS48 is an activator of PDK1 with an AC50 of 8 μM.
View activity & pricesDC10028NIH-12848
NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.
View activity & pricesDC9799CNDAC
CNDAC is the active component of sapacitabine. Sapacitabine is an oral nucleoside analog prodrug that acts through a dual mechanism. The compound interferes with DNA synthesis by causing single-strand DNA breaks and…
View activity & pricesDC7602DBeQ
DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A), respectively; DBeQ also inhibits Vps4 with an IC50 of 11.5 μM.
View activity & pricesDC7055AMG517
AMG 517 is a potent and selective vanilloid receptor-1 (TRPV1) antagonist with an IC50 of 0.5 nM.
View activity & pricesDC10124GSK180736A
GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.
View activity & pricesStructure information available on request
DC9834Dioscin
Dioscin(CCRIS 4123; Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines.
View activity & pricesDC7480PF-3274167（cligosiban）
Cligosiban (PF-3274167) is a high-affinity nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM.
View activity & pricesDCAPI1500Bepotastine Besilate
Bepotastine Beslilate (Bepreve) is a histamine H1 receptor anatagonist.
View activity & pricesDC10483INF39
INF39 is an irreversible and noncytotoxic NLRP3 inhibitor.
View activity & pricesDC10541Cyclo(RGDfC)
Cyclo (RGDfC), avb3 Integrin Binding Cyclic RGD Peptide,This is a cyclic RGDfC sequence, an integrin avb3-affine peptide.
View activity & pricesDC8399Cyclo(RGDyK)
Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
View activity & pricesDC5111PHA-680632
PHA-680632 is an aurora kinase inhibitor with IC50s of 27, 135 and 120 nM for aurora A, B and C, respectively.
View activity & pricesDC12028MDK7526(Protein degrader 1)
Protein degrader 1 hydrochloride is used in the synthesis of HaloPROTACs.
View activity & pricesDC9442PF-04457845
PF-04457845 is a highly efficacious and selective FAAH inhibitor with IC50 values is 7.2±0.63 nM and 7.4±0.62 nM for hFAAH and rFAAH, respectively.
View activity & pricesDC39083BI-3406(SOS1-IN-2)
BI-3406(SOS1-IN-2) is a Son of Sevenless 1 (SOS1) inhibitor extracted from patent WO2018115380A1, compound I-6, and it has an IC50 of 6 nM[1].
View activity & pricesDC68140PACAP-38 (31-38), human, mouse, rat
PACAP-38 (31-38), human, mouse, rat is a fragment containing the C-terminal 31-38 fragment of PACAP (1-38), human, ovine, rat (HY-P0221). PACAP-38 (31-38), human, mouse,
View activity & pricesDC7662GW4869
GW4869 is a noncompetitive neutral sphingomyelinase inhibitor with an IC50 of 1 μM.
View activity & pricesDC7188Lomeguatrib(PaTrin-2)
Lomeguatrib is a O6-methylguanine-DNA methyltransferase (MGMT) inhibitor, with IC50s of 9 nM in cell-free assay and ∼6 nM in MCF-7 cells.
View activity & pricesDC10587SPI 112
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively[1][2].
View activity & pricesDC10879AZ3451
AZ3451 is a protease-activated receptor-2 (PAR2) antagonist.
View activity & pricesDC8400AZD3839
AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.
View activity & pricesDC10500PF-06282999
PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potential useful for the treatment of cardiovascular diseases.
View activity & pricesDC8435LY2119620
LY2119620 is a high-affinity muscarinic M2/M4 receptor agonist.
View activity & pricesDC7191LY-2940680(Taladegib)
Taladegib (LY2940680) is an antagonist of the smoothened receptor.
View activity & pricesDC7107BI-78D3
BI-78D3 functions as a substrate competitive inhibitor of JNK, inhibit the JNK kinase activity (IC50=280 nM).
View activity & pricesDC10007Ibiglustat(Genz-682452）
Ibiglustat (Venglustat) is an inhibitor of glucosylceramide synthase extracted from patent WO 2015089067 A1, compound example 64.
View activity & pricesDC9930NOD-IN-1
NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.
View activity & pricesDC32856Devazepide
Devazepide is a potent, and orally active CCK1 (CCK-A) receptor antagonist that displays appetite-stimulant effects. It blocks the anorectic response to CCK-8 and increases food intake in rats following systemic and…
View activity & pricesDC12042TGN-020
TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
View activity & pricesStructure information available on request
DC9650Homoharringtonine
Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.
View activity & pricesDC7802IKK(epsilon)-IN-1 (IKKE-IN-1)
TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.
View activity & pricesDC7755TRCP6 inhibitor(SAR7334)
SAR7334 hydrochloride is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.
View activity & pricesDC10883GI254023X
GI254023X is a potent MMP9 and ADAM10 inhibitor with IC50s of 2.5 and 5.3 nM, respectively.
View activity & pricesDC4196Bleomycin Sulfate
Bleomycin sulfate is a DNA synthesis inhibitor with potent antitumor activity.
View activity & pricesDC10869Olodanrigan(EMA401)
Olodanrigan (EMA401), a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.
View activity & pricesDC9337Deguelin
Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to have an anti-tumor effect on several cancers; decrease levels of phosphorylated Akt. in vitro: Deguelin in a dose and time dependent…
View activity & pricesDC7448KU-60019
KU-60019 is an improved ATM kinase-specific inhibitor with IC50 of 6.3 nM.
View activity & pricesDC7406Dynasore
Dynasore is a cell-permeable dynamin inhibitor with an IC50 of 15 μM.
View activity & pricesDC8663UF010
UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.IC50 value: 0.06 μM (HDAC3), 0.1 μM…
View activity & pricesDC7051AG-18
Tyrphostin 23 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively.
View activity & pricesDC9485IKK-16(free base)
IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM.
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