IKK(epsilon)-IN-1 (IKKE-IN-1) chemical structure

Chemical structureResearch use only

CAT. NO. DC7802Featured

IKK(epsilon)-IN-1 (IKKE-IN-1)

Name: IKK(epsilon)-IN-1 (IKKE-IN-1)
Brand: DC Chemicals
SKU: DC7802
Price: 400.0 USD

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TotalUS$400

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Product overview

Description & Application

TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.

Parameter	Value
Chemical Name	IKK epsilon-IN-1
CAS No.	1292310-49-6
Synonyms	IKK epsilon-?IN-?1;Ikk epsilon-in-1;IKKε-IN-1;IKK;A-IN-1;IKKepsilon-IN-1;TBK1/IKKepsilon-IN-2;5-(2-((4-Morpholinophenyl)amino)pyrimidin-4-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile;5-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)-2-(oxan-4-yloxy)benzonitrile;AOB6849;BWABTWGSXHTHCG-UHFFFAOYSA-N;BCP10993;IKK(epsilon)-IN-1 (IKKE-IN-1);B4825;5-[2-[(4-morpholinophenyl)amino]py;TBK1/IKKε-IN-2
Formula	C26H27N5O3
M.Wt	457.5243
SMILES	O1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])OC1C([H])=C([H])C(C2C([H])=C([H])N=C(N=2)N([H])C2C([H])=C([H])C(=C([H])C=2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C=1C#N
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.

In Vitro

TBK1/IKKε-IN-2 (Cmpound #1) inhibits TBK1 biochemical function in Ulight kinase assay at 5 and 250 μM ATP concentration with IC50s of 0.6 and 2.6 nM, rsespectively. TBK1/IKKε-IN-2 inhibits IKKε biochemical function in Ulight kinase assay at 10 μM ATP with an IC50 of 3.9 nM. The IC50 of TBK1/IKKε-IN-2 in the Panc 02.13 proliferation assay is 5 μM[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

View online datasheet Request COA / MSDS

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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