BAY-985 chemical structure
Chemical structureResearch use only
CAT. NO. DC28732Featured

BAY-985

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TotalUS$850
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Product overview

Description & Application

BAY-985 is a highly potent, orally active and selective ATP-competitive dual inhibitor of TBK1 and IKKε with IC50s of 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε, respectively. Antitumor efficacy.

ParameterValue
Chemical NameBAY985;BAY 985
CAS No.2409479-29-2
SynonymsBAY985;BAY 985
FormulaC27H30F3N9O
M.Wt553.58
SMILESO=C(CC(F)(F)F)N1CCN([C@H](C)C2C=CN=C(NC3NC4C(=CC=C(C=4)C4C=C(N(C)C)N=CN=4)N=3)C=2)CC1
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

BAY-985 is a highly potent, orally active and selective ATP-competitive dual inhibitor of TBK1 and IKKε with IC50s of 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε, respectively. Antitumor efficacy.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Lefranc J, et al. Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor. J Med Chem. 2020 Jan 10.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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