DC Chemicals · Product datasheet

IKK(epsilon)-IN-1 (IKKE-IN-1) — Datasheet

CAT. NO. DC7802

Product page and current package options

ParameterValue
Chemical NameIKK epsilon-IN-1
CAS No.1292310-49-6
SynonymsIKK epsilon-?IN-?1;Ikk epsilon-in-1;IKKε-IN-1;IKK;A-IN-1;IKKepsilon-IN-1;TBK1/IKKepsilon-IN-2;5-(2-((4-Morpholinophenyl)amino)pyrimidin-4-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile;5-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)-2-(oxan-4-yloxy)benzonitrile;AOB6849;BWABTWGSXHTHCG-UHFFFAOYSA-N;BCP10993;IKK(epsilon)-IN-1 (IKKE-IN-1);B4825;5-[2-[(4-morpholinophenyl)amino]py;TBK1/IKKε-IN-2
FormulaC26H27N5O3
M.Wt457.5243
SMILESO1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])OC1C([H])=C([H])C(C2C([H])=C([H])N=C(N=2)N([H])C2C([H])=C([H])C(=C([H])C=2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C=1C#N
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.

In Vitro

TBK1/IKKε-IN-2 (Cmpound #1) inhibits TBK1 biochemical function in Ulight kinase assay at 5 and 250 μM ATP concentration with IC50s of 0.6 and 2.6 nM, rsespectively. TBK1/IKKε-IN-2 inhibits IKKε biochemical function in Ulight kinase assay at 10 μM ATP with an IC50 of 3.9 nM. The IC50 of TBK1/IKKε-IN-2 in the Panc 02.13 proliferation assay is 5 μM[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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