DC11803GLPG-1690(Ziritaxestat)
GLPG1690 is a first-in-class autotaxin (ATX) inhibitor, with an IC50 of 131 nM and Ki of 15 nM.
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Small Molecule Research Tools
2816 products · Page 28 of 59
Browse 372 research categories
DC11803DC9536Sertindole
Sertindole, a neuroleptic, is one of the newer antipsychotic medications available.In vitro studies showed that sertindole exerts a potent antagonism at serotonin 5-HT2A, 5-HT2C, dopamine D2, and αl adrenergic…
View activity & pricesDC9299GRA Ex-25
GRA Ex-25 is an inhibitor of glucagon receptor, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively.
View activity & pricesDC22604Anisomycin
Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
View activity & pricesDC10905Exo1
Exo1 is a chemical inhibitor of the exocytic pathway.
View activity & pricesDC70714PSB-16671
PSB-16671 is a novel orthosteric and allosteric activator of GPR84, activates human GPR84 with EC50 of 41.3 nM in cAMP accumulation assays. PSB-16671 is selective versus related fatty acid receptors and the…
View activity & pricesDC5172NLG919(GDC-0919)
IDO-IN-7 (NLG-919 analogue) is a a potent IDO1 inhibitor with an IC50 of 38 nM.
View activity & pricesDC8004AZD6482
AZD 6482 is a potent and selective p110β inhibitor with IC50 of 0.69 nM.
View activity & pricesStructure information available on request
DC4242Pinometostat(EPZ5676)
Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor with a Ki of 80 pM.
View activity & pricesDC33598GSK-805
GSK805, also known as ROR gamma-t-IN-1, is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without…
View activity & pricesDC7126QNZ(EVP4593)
QNZ shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. EVP4593 is a neuroprotective inhibitor of SOC channel.
View activity & pricesDC10295IPSU
IPSU is a selective, orally available and brain penetrant OX2R antagonist with a pKi of 7.85.
View activity & pricesDC26136MRTX849(Adagrasib)
MRTX849 is a potent, orally-available, and mutation-selective covalent inhibitor of KRAS G12C with potential antineoplastic activity. MRTX849 covalently binds to KRAS G12C at the cysteine at residue 12, locks the…
View activity & pricesDC21691SR 8278
SR8278 is a competitive nuclear heme receptor REV-ERB synthetic antagonist. SR8278 inhibits the REV-ERBα transcriptional repression activity with an EC50 of 0.47μM. SR8278 is used to regulate the metabolism in…
View activity & pricesDC9335AT7867
AT7867 is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.
View activity & pricesDC10289PE859
PE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively.
View activity & pricesDC8780Flavopiridol Hydrochloride
Flavopiridol Hydrochloride is a broad inhibitor of CDK, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively.
View activity & pricesDC9446Y15
Y15 is a direct and specific inhibitor of FAK auto-phosphorylation.
View activity & pricesDC11303CT7001(Samuraciclib hydrochloride）
CT7001 hydrochloride is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively.
View activity & pricesDC8172Lefamulin(BC-3781)
Lefamulin is a semi-synthetic compound that inhibits the synthesis of bacterial protein, which is required for bacteria to grow.
View activity & pricesDC31473Icatibant
Icatibant is a peptidomimetic drug consisting of ten amino acids, which is a selective and specific antagonist of bradykinin B2 receptors. It has been approved by the European Commission for the symptomatic treatment…
View activity & pricesDC11363NSC 185058
NSC 185058 is an ATG4B inhibitor. NSC185058 markedly attenuates autophagic activity[1].
View activity & pricesDC72829Zuranolone
Zuranolone(SAGE-217, CS-2797) is an orally active and potent neuroactive steroid and positive allosteric modulator of the GABAA receptor, with EC50s of 296 nM for α1β2γ2 receptor.
View activity & pricesDC43798preQ1 Dihydrochloride
preQ1 is a precursor in the biosynthesis of queuosine, a bacterial nucleoside incorporated into tRNA by tRNA transglycosylase. preQ1 binds to an aptamer domain on tRNA that acts as a riboswitch to repress gene…
View activity & pricesDC10756PF-06291826(Tafamidis)
Tafamidis(Fx1006A) is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.Target: OthersTafamidis is a drug for the amelioration of transthyretin-related hereditary…
View activity & pricesDC8354Intepirdine (SB-742457, RVT-101）
SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63; exhibits >100-fold selectivity over other receptors.SB-742457, a 5-HT6 receptor antagonist, which extends into Alzheimer disease (AD) sufferers…
View activity & pricesDC8212SR9011
SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively.
View activity & pricesDC42723GSK840
Novel potent and selective RIP3 kinase inhibitor
View activity & pricesDC10899Ralinepag
Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.
View activity & pricesDC21382EIDD-1931(NHC)
Beta-d-N4-hydroxycytidine (NHC) is a nucleoside analogue that has antipestivirus and antihepacivirus activities; inhibits the production of cytopathic BVDV RNA with EC90 of 5.4 uM, also has an EC50 of 5 uM for replicon…
View activity & pricesDC11407Asapiprant(BGE-175)
Asapiprant is a potent and selective DP1 receptor antagonist with a Ki of 0.44 nM..
View activity & pricesDC11735Remdesivir(GS-5734)
Remdesivir(GS-5734) is a nucleoside analogue, with effective antiviral activity, with EC50s of 74 nM for ARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells.
View activity & pricesDC7143GSK-343
GSK343 is a highly potent and selective EZH2 inhibitor with an IC50 of 4 nM.
View activity & pricesDC8429Verdinexor (KPT-335)
Verdinexor(KPT-335) is a novel, orally bioavailable selective inhibitor of nuclear export (SINE), inhibits nuclear export protein Exportin 1(XPO1/CRM1) against canine tumor cell lines; also reduce influenza virus…
View activity & pricesDC7064Apalutamide（ARN509）
Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM.
View activity & pricesDC7404DMXAA
Vadimezan (ASA-404; DMXAA), the vascular disrupting agent, is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines.
View activity & pricesDC10548Auten-99
Auten-99 is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14), acrossing the blood-brain barrier and exerting potent neuroprotective effects.
View activity & pricesDCH-004Magnolol
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively.
View activity & pricesDC10107BAY-876
BAY-876 is the first highly selective GLUT1 inhibitor with IC50 of 0.002 uM. show good metabolic stability in vitro and high oral bioavailability in vivo.
View activity & pricesDC11329Fadrozole (hydrochloride)
Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM.
View activity & pricesDC7005Cangrelor free acid
Cangrelor is a P2Y12 inhibitor, and was approved in June 2015 as an antiplatelet drug for intravenous application. Cangrelor is a high-affinity, reversible inhibitor of P2Y12 receptors that causes almost complete…
View activity & pricesDC9776Pazopanib Hydrochloride
Pazopanib Hydrochloride is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.
View activity & pricesDC23206Bax inhibitor peptide V5
Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
View activity & pricesDC8876Rimonabant(SR141716)
Rimonabant(SR141716) is a selective central cannabinoid (CB1) receptor inverse agonist with Ki of 1.8 nM.
View activity & pricesDC8516BMS-5
BMS-5 is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.
View activity & pricesDC8540DM-1(Mertansine)
Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome…
View activity & pricesDC8272U-104
U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM; low inhibition for CA I and CA II.
View activity & pricesDC8313BD1047.2HBr
BD-1047 dihydrobromide is a selective functional antagonist of sigma receptors, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.
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