DM-1(Mertansine) chemical structure
Chemical structureResearch use only
CAT. NO. DC8540Featured

DM-1(Mertansine)

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Product overview

Description & Application

Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery.

ParameterValue
CAS No.139504-50-0
SynonymsMertansine; DM 1; Maytansinoid DM 1; 139504-50-0; UNII-DDZ29HGH0E; DM1 Compound;
FormulaC35H48ClN3O10S
M.Wt738.29
SMILESSCCC(N(C(C(OC1CC(=O)N(C)C2=C(C(=CC(=C2)CC(C)=CC=CC(OC)C2(O)NC(OC(C2)C(C)C2OC12C)=O)OC)Cl)=O)C)C)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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