GSK-805 chemical structure
Chemical structureResearch use only
CAT. NO. DC33598Featured

GSK-805

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TotalUS$650
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Product overview

Description & Application

GSK805, also known as ROR gamma-t-IN-1, is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA binding.

ParameterValue
Chemical NameN-[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)-benzeneacetamide
CAS No.1426802-50-7
SynonymsGSK805; GSK 805; GSK-805; ROR gamma-t-IN-1; RORγt Inverse Agonist II;
FormulaC23H18Cl2F3NO4S
M.Wt532.3552
SMILESO=C(NC1=CC(Cl)=C(C2=CC=CC=C2OC(F)(F)F)C(Cl)=C1)CC3=CC=C(S(=O)(CC)=O)C=C3
Purity98%

Biological Activity

GSK805, also known as ROR gamma-t-IN-1, is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA binding.

In Vitro

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In Vivo

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References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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