DC6308Sofosbuvir（PSI7977，GS-7977）
Sofosbuvir (PSI-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM.
View activity & pricesDC Chemicals · Research reagentsDC6308 
DC22228
DC7101
DC2086
DC7550
DC60394
DC7071
DC7035
DC9424
DC10821
DC7253
DC7528
DC7193
DC8459
DC22298
DC7206
DC7365
DC2093
DC7543
DC7708
DC22211
DC6315
DC7535
DC7252
DC10799
DC60152
DC7309
DC7731
DC7584
DC11468
DC8644
DC7698
DC7518
DC7162
DC7620
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DC8039
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DC5142
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DC6305
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Other Research Tools
1099 products · Page 1 of 23
All small molecule research tools
DC6308DC22228Fluzoparib
Fluzoparib (SHR-3162) is a novel, potent and orally available inhibitor of PARP; potently inhibited PARP1 enzyme activity and induced DNA double-strand breaks, G2/M arrest and apoptosis in homologous recombination…
View activity & pricesDC7101CGK733
CGK733 is a potent ATM/ATR inhibitor, used for the research of cancer.
View activity & pricesDC2086PF-670462
PF-670462 is a potent and selective inhibitor of casein kinase (CK1ε and CK1δ), with IC50s of 7.7 nM and 14 nM, respectively.
View activity & pricesDC7550PBIT
PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1(JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1 ) histone demethylase an IC50 of about 3 μM . PBIT also inhibits JARID1A and JARID1C with…
View activity & pricesDC60394PU-WS13
PU-WS13 is a selective Grp94 inhibitor, with an EC50 of 0.22 μM.
View activity & pricesDC7071AWD 131-138(Imepitoin)
AWD 131-138(Imepitoin) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.
View activity & pricesDC7035Merestinib(LY2801653 dihydrochloride)
Merestinib dihydrochloride (LY2801653 dihydrochloride) is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (Ki) of 2 nM.
View activity & pricesDC9424Fenoldopam (mesylate)
Fenoldopam(SKF 82526) mesylate is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.Target: D1 ReceptorFenoldopam is a selective dopamine-1 (DA1) agonist with…
View activity & pricesDC10821PKG drug G1
PKG drug G1 targets C42 of PKG Iα. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.
View activity & pricesDC7253CID-2011756
CID 2011756 is an ATP competitive PKD inhibitor, with an IC50 of 3.2 µM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50, 0.6 and 0.7 µM, respectively). CID…
View activity & pricesDC7528VGX-1027(GIT 27)
VGX-1027(GIT27) is an isoxazole compound that exhibits various immunomodulatory properties; reduce the secretion of IL-1beta, TNF-alpha and IL-10 from purified murine macrophages.Administration of VGX-1027 to NOD mice…
View activity & pricesDC7193MBX-2982
MBX-2982 is a selective, orally-available G protein-coupled receptor 119 (GPR119) agonist.
View activity & pricesStructure information available on request
DC8361CDDO(Bardoxolone; RTA 401)
Bardoxolone is a novel nuclear regulator factor (Nrf-2) activator.
View activity & pricesDC8459Palovarotene(R 667)
Palovarotene is a nuclear retinoic acid receptor γ (RAR-γ) agonist.
View activity & pricesDC22298AMG-510(Sotorasib)
AMG-510 is a specific covalent inhibitor of K-RAS(G12C) with potential antineoplastic activity. Upon oral administration, KRAS mutant-targeting AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA…
View activity & pricesDC7206R1530
R1530 is the multikinase inhibitor with potential antiangiogenesis and antineoplastic activities.R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in…
View activity & pricesDC7365ATB-346
ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity. IC50 value: Target: COX-2 ATB-346 suppressed gastric prostaglandin E(2) synthesis as effectively as naproxen, but…
View activity & pricesDC2093Genistin
Genistin is the major isoflavonoid of soybeans and soy products.
View activity & pricesDC7543Bromosporine
Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively.IC50 value: 0.41/0.29/0.122/0.017 uM (BRD2/BRD4/BRD9/CECR2)…
View activity & pricesDC7708UNBS5162
UNBS5162 is a pan-antagonist of CXCL chemokine expression, with anti-tumor activity.
View activity & pricesDC22211ALG1001 (Risuteganib)
ALG1001 (Risuteganib, ALG-1001) is a first-in-class, RGD class oligopeptide that inhibits integrin receptors (αvβ3, αvβ5, and α5β1) associated with angiogenesis; ALG1001 inhibits an integrin-mediated pathway of the…
View activity & pricesDC6315GSK2636771
GSK2636771 is a potent, selective and oral inhibitor of PI3Kβ with a Ki of 0.89 nM and an IC50 of 5.2 nM, showing 900-fold selectivity over p110α and p110γ, and 10-fold selectivity over p110δ isoforms.
View activity & pricesDC7535Y-320
Y-320 is a new phenylpyrazoleanilide immunomodulator; inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.Y-320 inhibited IL-17 production by CD4 T cells stimulated with IL-15…
View activity & pricesDC7252PR-619
PR-619 is a broad-range DUB inhibitor with EC50 of 3.93, 4.9, 6.86, 7.2, and 8.61 μM for USP4, USP8, USP7, USP2, and USP5, respectively.
View activity & pricesDC10799SSR-240612 HCl
SSR240612 is a potent, and orally active specific non-peptide bradykinin B1 receptor antagonist, with Kis of 0.48 nM and 0.73 nM for B1 kinin receptors of human fibroblast MRC5 and HEK cells expressing human B1…
View activity & pricesDC60152SHIN2
SHIN-2 is a novel SHMT inhibitor, increasing survival in NOTCH1-driven mouse primary T-ALL in vivo
View activity & pricesDC7309TAK-960
TAK-960 is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM at 10 μM ATP; TAK-960 also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM,…
View activity & pricesDC7731Emapunil(AC-5216)
Emapunil(AC-5216;XBD-173) is a translocator protein[TSPO (18 kDa)] ligand.IC50 value:Target: TSPO ligandXBD173 enhanced gamma-aminobutyric acid-mediated neurotransmission and counteracted induced panic attacks in…
View activity & pricesDC7584RG108
RG108 is a non-nucleoside inhibitor of DNA methyltransferase with an IC50 of 115 nM.
View activity & pricesDC11468Rbin-1
Rbin-1 is a potent, reversible, and specific chemical inhibitor of eukaryotic ribosome biogenesis. Rbin-1 inhibits the ATPase with GI50 of 136±7 nM.
View activity & pricesDC8644Lorcaserin Hydrochloride
Lorcaserin (APD-356, trade name upon approval Belviq,expected trade name during development, Lorqess is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic.…
View activity & pricesDC7698AC 55541
AC-55541 is a novel small-molecule protease-activated receptor 2(PAR2) agonist; activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with…
View activity & pricesDC7518Tirasemtiv
Tirasemtiv is an activator of the fast skeletal muscle troponin complex.
View activity & pricesDC7162SNS-314 Mesylate
SNS-314 is a potent and selective aurora kinase inhibitor with IC50s of 9, 31, and 6 nM for aurora A, B and C, respectively.
View activity & pricesStructure information available on request
DC12804JND3229
JND3229 is a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy (IC50 = 5.8 nM).
View activity & pricesDC7620MS436
MS436 is a new class of bromodomain inhibitor, exhibits potent affinity of an estimated Ki=30-50 nM for the BRD4 BrD1 and a 10-fold selectivity over the BrD2.
View activity & pricesDC1033S3I-201 (NSC-74859)
NSC 74859 is a selective Stat3 inhibitor with an IC50 of 86±33 μM.
View activity & pricesDC8290(S)-PFI-2 HCl
Negative control of (R)-PFI 2 hydrochloride. Exhibits 500-fold lower activity in a SETD7 enzymatic assay (IC50 = 1 μM) compared to the active enantiomer.
View activity & pricesDC8039SP-420
SP-420 is a desferrithiocin analogue with iron-clearing efficiency with ICE value of 26.7; more potent than desferrithiocin.
View activity & pricesDC7811Fexinidazole
Fexinidazole is an antiparasitic agent. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani. The biologically…
View activity & pricesDC7527VE-822 (Berzosertib)
Berzosertib (VE-822) is an ATR inhibitor with a Ki value of less than 0.2 nM. It also inhibits ATM with a Ki of 34 nM.
View activity & pricesDC5142StemRegenin 1(SR-1)
StemRegenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with IC50 of 127 nM.
View activity & pricesDC7444kobe2602
kobe2602 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD; exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 149 ± 55…
View activity & pricesDC6305LY364947
LY-364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, and exhibits 7-fold selectivity over TGFβR-II.
View activity & pricesDC7420GNF-5
GNF-5, an analogue of GNF-2 with improved pharmacokinetic properties, is a selective non-ATP competitive inhibitor of Bcr-Abl with an IC50 value of 0.22±0.1 uM (Wild type Abl).IC50 Value: 0.22±0.1 uM (Wild type Abl)…
View activity & pricesDC7184Lcl-161
LCL161 is a IAP inhibitor which inhibits XIAP in HEK293 cell and cIAP1 in MDA-MB-231 cell with IC50s of 35 and 0.4 nM, respectively.
View activity & pricesDC7395Dapivirine
apivirine(TMC 120, TMC 120 R147681) is a NNRTI for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates.
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