DC8212SR9011
SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively.
View activity & pricesDC Chemicals · Research reagentsDC8212 
DC42723
DC10899
DC23206
DC12285
DC2056
DC7222
DC26008
DC21940
DC11274
DC12522
DC23204
DC8126
DC26147
DC23207
DC12541
DC12542
DC8749
DC8094
DC12178
DC31035
DC21518
DC7403
DC9620
DC8640
DC10564
DC9771
DC20571
DC21233
DC20449
DC10494
DC25055
DC22540
DC9769
DC7416
DC20241
DC12074
DC20439
DC22928
DC7361
DC20282
DC21064
DC11055
DC9991
DC21044
DC10692
DC26024
DC12356
Other Research Tools
1099 products · Page 9 of 23
All small molecule research tools
DC8212DC42723GSK840
Novel potent and selective RIP3 kinase inhibitor
View activity & pricesDC10899Ralinepag
Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.
View activity & pricesDC23206Bax inhibitor peptide V5
Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
View activity & pricesDC12285CID 1375606
CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27.
View activity & pricesDC2056Droxidopa (L-DOPS,SM-5688)
Droxidopa(L-DOPS, SM5688) is a synthetic amino acid precursor which acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); capable of crossing the protective blood–brain…
View activity & pricesDC7222P005091(P5091)
P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with an EC50 of 4.2 μM.
View activity & pricesDC26008DSP2230
DSP-2230 is a selective Nav1.7/Nav1.8 blocker[1][2].
View activity & pricesDC21940Pizuglanstat
Pizuglanstat is a potent, selective prostaglandin D synthase inhibitor.
View activity & pricesDC11274AMPPD
AMPPD, 1,2 - dioxo-cyclohexane derivatives, is a new biochemistry ultrasensitive alkaline phosphatase substrate.
View activity & pricesDC12522MKK7-COV-3
MKK7-COV-3 (MKK7 Covalen inhibitor 3) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 5 nM, displays >1,000-fold selectivity over MKK4 (IC50=7.81 uM), shows EC50 of 1.3 uM for reduction of p-JNK…
View activity & pricesDC23204WZ8040
WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).WZ8040 is 30- to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against…
View activity & pricesDC8126CALCIUM IONOPHORE II
N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide (Calcium ionophore II) is a lipophilic ionophore that can be used in preparing calcium ion-selective electrode[1].
View activity & pricesDC26147DANUGLIPRON（PF-06882961）
PF-06882961 is a potent, orally bioavailable agonist of the glucagon-like peptide-1 receptor (GLP-1R)
View activity & pricesDC23207JNJ-17203212
JNJ-17203212 is a novel and selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1.
View activity & pricesDC12541iGOT1-01
iGOT1-01 is a small molecule inhibitor of aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1 (GOT1)) with IC50 of 11.3 uM.
View activity & pricesDC12542GOT1 inhibitor 2c
GOT1 inhibitor 2c is a first-in-class, non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with IC50 of 8.2 uM.
View activity & pricesDC8749Plinabulin
Plinabulin (NPI-2358) is a vascular disrupting agents (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells.
View activity & pricesDC8094Ys-49
YS 49 inhibits Ang II-stimulated proliferation of VSMCs via induction of HO-1.YS-49 is a novel positive inotropic isoquinoline compound. YS-49 has potential as a therapeutic strategy for the pathogenesis of Ang…
View activity & pricesDC12178Pemigatinib
Pemigatinib is a selective FGFR inhibitor in development for the treatment of patients with cholangiocarcinoma.
View activity & pricesDC31035Hydroxy dabrafenib
Hydroxy-dabrafenib is one of the three major metabolites of dabrafenib.
View activity & pricesDC21518PLX5622
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor, for extended and specific microglial elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties…
View activity & pricesDC7403Dimethyloxaloylglycine(DMOG)
DMOG (Dimethyloxallyl Glycine) is a cell-permeable and competitive inhibitor of HIF-1α prolyl hydroxylase (HIF-PH).
View activity & pricesDC9620EMD638683
EMD638683 is a potent SGK1 inhibitor with an IC50 of 3 uM. The serum- and glucocorticoid-inducible kinase 1 (SGK1) is transcriptionally upregulated by mineralocorticoids and activated by insulin. EMD638683 could serve…
View activity & pricesDC86401-NM-PP1
1-NM-PP1 is a cell permeable protein kinase D (PKD) inhibitor with an IC50 of 0.398 μM.
View activity & pricesDC10564BAR 502
BAR502 is a dual FXR and GPBAR1 agonist with IC50 values of 2 μM and 0.4 μM, respectively.
View activity & pricesDC9771ACU4429,ACU 4429,ACU-4429
Emixustat hydrochloride strongly inhibits 11-cis-retinol production with IC50 values of 232 ± 3 nM.Emixustat hydrochloride is a novel visual cycle modulator, in healthy volunteers. Oral Emixustat was safe and well…
View activity & pricesDC20571TRIF agonist AV-C
TRIF agonist AV-C is a novel TRIF pathway agonist that activates innate and interferon-associated responses, strongly inhibits replication of ZIKV, CHIKV, and DENV (IC90~5 uM); activates IFNAR-mediated transcription…
View activity & pricesDC21233LJ 001
LJ 001 ((LJ-001, LJ001) is a broad-spectrum antiviral agent targeting entry of enveloped viruses, including influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1;…
View activity & pricesDC20449MI-2-2
MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and…
View activity & pricesDC10494BMS813160
BMS-813160 is the first dual CCR2/CCR5 antagonist to enter clinical development for cardiovascular.
View activity & pricesDC25055Prodigiosin
Prodigiosin (Prodigiosine) is a secondary metabolite of Symbiotic bacteria, with anti-fungal and anti-cancer activity[1][2].
View activity & pricesDC22540Pasireotide
Pasireotide(SOM 230) is a stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9 respectively).
View activity & pricesDC9769NVP-CGM097 (CGM-097)
NVP-CGM097 is a potent and selective MDM2 inhibitor with IC50 of 1.7±0.1 nM for hMDM2.
View activity & pricesDC7416Taselisib（GDC-0032）
GDC-0032 is a potent, next-generation β iso Form-sparing PI3K inhibitor targeting PI3Kα/δ/γ with IC50 of 0.29 nM/0.12 nM/0.97nM, >10 fold selective over PI3Kβ. IC50 Value: 0.29 nM/0.12 nM /0.97 nM(PI3Kα/δ/γ) Target:…
View activity & pricesDC20241PIH(Pyridoxal isonicotinoyl hydrazine)
Pyridoxal isonicotinoyl hydrazone (PIH) is a lipophilic, tridentate Fe-chelating agent that shows high Fe chelation efficacy[1].
View activity & pricesDC12074HM30181 mesylate
HM30181 mesylate is a competitive and potent P-glycoprotein inhibitor.
View activity & pricesDC20439LXRβ agonist 17
A novel, potent, orally active liver X receptor β (LXRβ) agonist with Ki/EC50 of 3/21 nM, displays 27-fold selectivity over LXRα; also exhibits excellent selectivity against other nuclear hormone receptors…
View activity & pricesDC22928BMS-1001
A potent PD-1/PD-L1 interaction inhibitor with IC50 of 2.25 nM in a homogenous time-resolved fluorescence binding assay.
View activity & pricesDC7361Asunaprevir
Asunaprevir is a potent hepatitis C virus (HCV) NS3 protease inhibitor, with IC50 of 0.2 nM-3.5 nM.
View activity & pricesDC20282GSK199
GSK-199 hydrochloride is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 250 nM in FP binding assay (0.2 mM Ca), 200 nM in PAD4 NH3 release inhibition assay; shows high…
View activity & pricesDC21064GR-127935 hydrochloride
GR-127935 potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor.
View activity & pricesDC11055Desmethyl dabrafenib
Desmethyl dabrafenib (GSK2167542, Dabrafenib metabolite M8) is the desmethyl- metabolic byproduct of Dabrafenib, ameliorates developmental pathologies of Kabuki Syndrome in vivo.
View activity & pricesDC9991MQAE
MQAE is a fluorescent indicator that is quenched via collision with chloride, and is more sensitive and selective than 36Cl and microelectrode-based methods for chloride measurement in cells.
View activity & pricesDC21044GGTI 2418
GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also…
View activity & pricesDC10692R162
R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1), with anti-cancer properties.
View activity & pricesDC26024GNE-8324
GNE-8324 is a potent and selective NMDA receptor PAM.
View activity & pricesDC123562-NBDG
2-NBDG is a fluorescent indicator for direct glucose uptake measurement and also is an indicator of cell viability.
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