DC7669Kartogenin (KGN)
Kartogenin is an inducer of differentiation of human mesenchymal stem cells into chondrocytes.
View activity & pricesDC Chemicals · Research reagentsDC7669 
DC26017
DC22896
DC20891
DC21740
DC8616
DC31764
DC10196
DC9743
DC7267
DCAPI1520
DC8988
DC20799
DC10776
DC26170
DC8729
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DC34242
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DC31068
DC23990
DC8388
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DC23507
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DC39203
DC9186
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DC22627
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1099 products · Page 18 of 23
All small molecule research tools
DC7669DC26017Golotimod (SCV-07)
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage…
View activity & pricesDC22896Israpafant
Israpafant (Y24180) is a specific antagonist of PAF receptor that inhibits PAF-induced rabbit platelet aggregation in vitro (IC50=3.84 nM), with little effect on adenosine diphosphate- or arachidonic acid-induced…
View activity & pricesDC20891ATN-224
ATN-224 is an oral Cu2+/Zn2+-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC50 of 17.5±3.7 nM.
View activity & pricesDC21740TC-2153
TC-2153 is a specific, small moelcule inhibitor of neuron-specific tyrosine phosphatase STEP with IC50 of 24.6 nM; increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B, and exhibits no…
View activity & pricesDC8616S-(5'-Adenosyl)-L-methionine chloride（SAM）
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all…
View activity & pricesDC31764Miconazole
Miconazole is an imidazole antifungal agent commonly applied topically to the skin or to mucous membranes to cure fungal infections. It works by inhibiting the synthesis of ergosterol, a critical component of fungal…
View activity & pricesDC10196Lodoxamide tromethamine
Lodoxamide tromethamine (U 42585 E) is a medication for the treatment of prophylaxis of mast cell-mediated allergic disease.
View activity & pricesDC9743CB1954(Tretazicar)
Tretazicar (CB 1954), an antitumor prodrug, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand…
View activity & pricesDC7267Riociguat (BAY 63-2521)
Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
View activity & pricesDCAPI1520S-adenosyl-L-methionine(Ademetionine)
S-adenosyl-L-methionine(Ademetionine) is an intermediate metabolite of methionine. Its involvement in methylation assists in cellular growth and repair, maintains the phospho-bilipid layer in cell membranes. It also…
View activity & pricesDC8988Imiquimod
Imiquimod is an immune response modifier and a toll-like receptor 7 agonist.
View activity & pricesDC20799BK-1361(cyclo(RLsKDK))
BK-1361(BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM; displays no significant activity against ADAM 9, 10, 12, 17 , as…
View activity & pricesDC10776Cordycepin
Cordycepin, which is a nucleoside derivative isolated from Cordyceps, inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner.
View activity & pricesDC26170JA2131
JA2131 is a selective bioavailable poly(ADP-ribose) glycohydrolase (RARG) inhibitor with IC50 of 0.4 μM.
View activity & pricesDC8729Bifeprunox
Bifeprunox is a potent dopamine D2-like and 5-HT1A receptor partial agonist with pKis of 7.19 and 8.83 for cortex 5-HT1A and striatum D2, and a pEC50 of 6.37 for hippocampus 5-HT1A, respectively. Bifeprunox is an…
View activity & pricesDC22637BKI1369
BKI-1369 is a bumped kinase inhibitor (BKI). BKI-1369 increases human Ether-a-go-go-related gene (hERG)-inhibitory activity with an IC50 of 1.52 μM. BKI-1369 reduces the parasite burden and diseases severity in the…
View activity & pricesDC10678fluticasone
Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary…
View activity & pricesDC34242MG115
MG-115(MG 115) is an inhibitor of NFκB in the cytoplasm by acting on IKK or the proteasome.
View activity & pricesDC23789AK778
AK778 (Col001) is a small-molecule compound that inhibits the interaction of Hsp47 with collagen, competitively inhibits the interaction and causes the inhibition of collagen secretion by destabilizing the collagen…
View activity & pricesDC26112SLMP53-1
A novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells; enhances p53 transcriptional activity and restores wt-like DNA…
View activity & pricesDC31068Tivozanib (hydrate)
Tivozanib is an orally available, selective VEGFR inhibitor with IC50 values of 0.21, 0.16, and 0.24 nM for VEGFR1, VEGFR2, and VEGFR3, respectively.
View activity & pricesDC23990N-Desethyl Sunitinib
N-Desethyl Sunitinib is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively.
View activity & pricesDC83888-Bromo-cAMP
8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA)[1].
View activity & pricesDC12626MitoBloCK-11
MitoBloCK-11 (MB-11) is a s mall molecule inhibitor of mitochondrial protein import possibly acts through transport protein Seo1, but not Tom70 or Tom20; inhibits precursor proteins that contain hydrophobic segments,…
View activity & pricesDC31174Doxorubicin
Doxorubicin free base, also called doxorubicin, is an anthracycline antibiotic with antineoplastic activity. Approved API for cancer therapeutic use is doxorubicin HCl. Doxorubicin, isolated from the bacterium…
View activity & pricesDC23507FC131
FC131 TFA is a CXCR4 antagonist that inhibits the binding of [125I]-SDF-1 to CXCR4 with an IC50 value of 4.5 nM. FC131 TFA has anti-HIV activity.
View activity & pricesDC8285Acotiamide HCl
Acotiamide monohydrochloride trihydrate is an orally active and first-in-class gastroprokinetic agent for the treatment of functional dyspepsia. Acotiamide monohydrochloride trihydrate enhances acetylcholine released…
View activity & pricesDC21072Voxilaprevir
Voxilaprevir (GS-9857) is a fluorinated macrocyclic hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor with potent in vitro antiviral activity against genotypes 1-6 HCV and broad coverage of…
View activity & pricesDC26224CTOP
CTOP is a potent and highly selective μ-opioid receptor antagonist. CTOP antagonizes the acute morphine-induced analgesic effect and hypermotility. CTOP enhances extracellular dopamine levels in the nucleus accumbens.…
View activity & pricesDC21644SHP504
SHP504 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 21 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).downregulates DUSP6 mRNA, a downstream MAPK pathway marker, in…
View activity & pricesDC7333UNC-1999
UNC1999 is a SAM-competitive, potent and selective inhibitor of EZH1/2 with IC50s of 10 nM and 45 nM, repectively.
View activity & pricesDC5889Fludarabine
Fludarabine(NSC 118218), a DNA synthesis inhibitor, is a chemotherapy drug used in the treatment of hematological malignancies.Fludarabine or fludarabine ph osphate (Fludara) is a chemotherapy drug used in the…
View activity & pricesDC39048Zamicastat
Zamicastat is a concentration-dependent dual P-gp and BCRP inhibitor with IC50 values of 73.8±7.2 μM and 17.0±2.7 μM, respectively.
View activity & pricesDC39204CID 139600315(GNF-4877)
GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50…
View activity & pricesDC39203JWG-071
JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology[1].
View activity & pricesDC9186Lercanidipine HCl
Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class.Lercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels…
View activity & pricesDC26220VKGILS-NH2
VKGILS-NH2 is a reversed amino acid sequence control peptide for SLIGKV-NH2 (protease-activated receptor 2 (PAR2) agonist). VKGILS-NH2 has no effect on DNA synthesis in cells[1][2].
View activity & pricesDC22627Trametinib DMSO solvate
Trametinib DMSO solvate is a potent MEK inhibitor that specifically inhibits MEK1/2, with an IC50 value of about 2 nM.
View activity & pricesDC65648Retatrutide (LY3437943)
LY3437943 is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). LY3437943 inhibits for human GCGR,…
View activity & pricesDC23302Disarib
Disarib is a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain, demonstrates strong affinity to BCL2, but not to other antiapoptotic BCL2 family members(BCL-xL, BCL2A1 etc.); is a novel BCL2…
View activity & pricesDC9103Rebeprazole sodium
Rabeprazole sodium(LY307640 sodium) is an antiulcer drug in the class of proton pump inhibitors.Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not…
View activity & pricesDC22243TAS0728
TAS0728 is a potent, selective, oral active, irreversible and covalent-binding HER2 inhibitor, binds to HER2 at C805, inhibits its kinase activity, with an IC50 of 13 nM. TAS0728 shows IC50s of 4.9, 8.5, 31, 65, 33,…
View activity & pricesDC10064GSK-F1
GSK-F1 is a potent inhibitor of PI4KA. It has markedly better pharmacokinetic properties in vivo with respects to GSK-A1 (SYN-1219). GSK-F1 does not cross the blood-brain barrier. Phosphatidylinositol 4-kinase type…
View activity & pricesDC32374Nicotinamide Mononucleotide
β-nicotinamide mononucleotide is an intermediate in NAD+ biosynthesis produced from nicotinamide (NAM) and phosphoribosyl pyrophosphate (PRPP) by nicotinamide phosphoribosyl transferase enzyme.
View activity & pricesDC39201NMDAR/TRPM4 inhibitor 8
NMDAR/TRPM4 inhibitor 8 (Compound 8) is a neuroprotective NMDAR-TRPM4 interaction interface inhibitor but spare the critical healthy NMDAR function.
View activity & pricesDC11162MID-1
MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in…
View activity & pricesDC28247Aripiprazole Lauroxil
Aripiprazole lauroxil, an N-acyloxymethyl prodrug of aripiprazole, is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to…
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