AK778 chemical structure
Chemical structureResearch use only
CAT. NO. DC23789Featured

AK778

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TotalUS$500
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Product overview

Description & Application

AK778 (Col001) is a small-molecule compound that inhibits the interaction of Hsp47 with collagen, competitively inhibits the interaction and causes the inhibition of collagen secretion by destabilizing the collagen triple helix.

ParameterValue
Chemical Name2-[[5-(1H-Benzimidazol-2-yl)-2-methylphenyl]iminomethyl]-4-benzyl-6-nitrophenol
CAS No.328906-67-8
SynonymsOprea1_106567;AK778;2-(((5-(1H-Benzo[d]imidazol-2-yl)-2-methylphenyl)imino)methyl)-4-benzyl-6-nitrophenol;2-[[5-(1H-Benzimidazol-2-yl)-2-methylphenyl]iminomethyl]-4-benzyl-6-nitrophenol
FormulaC28H22N4O3
M.Wt462.499286174774
SMILESOC1C(=CC(=CC=1/C=N/C1=C(C)C=CC(=C1)C1=NC2C=CC=CC=2N1)CC1C=CC=CC=1)[N+](=O)[O-]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

AK778 (Col001) is a small-molecule compound that inhibits the interaction of Hsp47 with collagen, competitively inhibits the interaction and causes the inhibition of collagen secretion by destabilizing the collagen triple helix.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

References 1. Ito S, et al. J Biol Chem. 2017 Dec 8;292(49):20076-20085. View Related Products by Target Heat Shock Protein (HSP)

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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