DC49089Cyanosafracin B
Cyanosafracin B is a starting material for synthesis of Ecteinascidin ET-743 and Phthalascidin Pt-650.
View activity & pricesDC Chemicals · Research reagentsDC49089 
DC21964
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1099 products · Page 16 of 23
All small molecule research tools
DC49089DC21964TRPM4 inhibitor 5
TRPM4 inhibitor 5 is a potent and selective inhibitor of TRPM4 with IC50 of 1.5 uM (Na+ influx); selectively inhibits TRPM4 overexpressed in HEK293 cells (IC50=1.8 uM) using classical patch-clamp electrophysiology…
View activity & pricesDC60304TRPM4-IN-2
TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer[1][2].
View activity & pricesDC409862-Nitrosopyridine
2-Nitrosopyridine is a nitroso compound can be used to synthesize antibiotics.
View activity & pricesDC20028Benznidazole (Synonyms: Benznidazol; Ro 07-1051; Ro 71051)
In Vivo Benznidazole (100 mg/kg/day, p.o., 30 days) produces a decrease in electrocardiographic alterations, fewer modifications in the affinity and density of cardiac-receptors, and few isolated areas of fibrosis in…
View activity & pricesDC60095NV-5138
NV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 possesses rapid antidepressant effects[1][2].
View activity & pricesDC43625Paprotrain
Reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2)
View activity & pricesDC45758Revumenib
SNDX-5613 is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute…
View activity & pricesDC60279ART812
ART812 is a DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 has an IC50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ)[1][2].
View activity & pricesDC67275VU0364739
VU0364739 is a selective inhibitor of phospholipase D2 (PLD2) with an IC50 value of 22 nM. Phospholipase D (PLD) enzymes, including PLD1 and PLD2, are involved in various cellular processes, such as signal…
View activity & pricesDC23181(R)-GNE-140
(R)-GNE-140 (GNE-140) is a novel potent, selective lactate dehydrogenase (LDH) inhibitor with IC50 of 3, 5, and 5 nM for LDHA, LDHB, and LDHC, respectively; displays no inhibition on malate MDH-1, MDH-2 (IC50>10 uM for…
View activity & pricesDC65705Cagrilintide
Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant…
View activity & pricesDC9544Stenabolic (SR9009)
SR9009 is a REV-ERBα/β agonist with IC50s of 670 nM and 800 nM for REV-ERBα and REV-ERBβ, respectively.
View activity & pricesDC11456MeO-Suc-Arg-Pro-Tyr-pNA
S-2222 is chromogenic substrate for factor Xa. When catalyzed by factor Xa, it releases a free pNA which could be detected by a spectrophotometer at 405 nm wavelength.Chromogenic substrate S-2222 can be used in many…
View activity & pricesDC74218UT-59
UT-59 is a specific inhibitor that targets the cholesterol-sensing membrane protein Scap (SREBP cleavage-activating protein). It functions by binding to Scap's cholesterol-binding site, which prevents Scap from…
View activity & pricesDC42587Bexin-1
Bexin-1 is a specific inhibitor that targets Munc13-4, a protein critical for regulated exocytosis, particularly in secretory cells such as immune cells (e.g., cytotoxic T lymphocytes, mast cells) and neuroendocrine…
View activity & pricesDC66611PF-07328948
PF-07328948 is a first-in-class branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with IC50 of 15 nM and shows a high degree selectivity over a number of kinases and other off-targets. PF-07328948 is the…
View activity & pricesDC22197PZ09(PKC-9)
PZ09 (PKC-zeta inhibitor 9, PKC-ζ inhibitor PZ9) is a potent, isoform selective PKC-zeta (PKC-ζ) inhibitor with IC50 of 5.18 nM, displays excellent selectivity (>200-fold) over other PKC isoforms with exception of…
View activity & pricesDC36079Artemisitene
Artemisitene is an antimalarial agent and the oxidized form of Artemisinin. Artemisinin precursors are the important basic substances for biosynthesis of Artemisinin, including Artemisinic acid, Artemisinin B,…
View activity & pricesDC24079DG-172 dihydrochloride
DG-172 is a novel PPARβ/δ-selective ligand showing high binding affinity (IC50= 27 nM) and potent inverse agonistic properties; inhibits agonist-induced activity of PPARβ/δ, enhances transcriptional corepressor…
View activity & pricesDC8162Dasotraline(SEP-225289) free base
Dasotraline is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
View activity & pricesDC58312Divarasib
GDC-6036 is a novel oral KRAS G12C inhibitor.
View activity & pricesDC65023ACE-083
ACE083 is a Locally acting muscle-promoting agent
View activity & pricesDC23024N-65828
NCI-65828 (designated as N 65828) is a small-molecule inhibitor targeting angiogenin (ANG), a protein critical for angiogenesis and cellular proliferation. Its therapeutic potential stems from selective suppression of…
View activity & pricesDC11380Difelikefalin (CR845)
Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in…
View activity & pricesDC10424Fluorescein-5-maleimide
Fluorescein-5-maleimide is a fluorescent thiol-reactive dye used to conjugate fluorescein to proteins (excitation: 494 nm, emission: 519 nm).
View activity & pricesDC30015NVS-ZP7-4
NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. NVS-ZP7-4 altered zinc in the ER, and an analog of…
View activity & pricesDC23001Hypocrellin B
Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B…
View activity & pricesDC75641GENZ-644282 TFA salt
Genz-644282, also known as SAR402674, is a non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity. Topoisomerase I inhibitor Genz-644282 binds to and inhibits the enzyme topoisomerase I,…
View activity & pricesDC8002CPI-360 (R)
CPI-360 is a compound in design and preparation of wew palladium precatalysts for C-C and C-N cross-coupling reactions. For the detailed information of CPI-360 (R), the solubility of CPI-360 (R) in water, the…
View activity & pricesDC8808BX 513 hydrochloride
BX-513 hydrochloride inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Selective CCR1 receptor antagonist (Ki values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors…
View activity & pricesDC31451CCS-1477(CBP-IN-1)
CCS-1477(CBP-IN-1) is a potent p300/CBP bromodomain inhibitor[1].
View activity & pricesDCC0689Aqf026
Novel agonist of the water channel aquaporin-1 (AQP1)
View activity & pricesDC74557PREX-in1
PREX-in1 is a specific small-molecule inhibitor of P-Rex1 and P-Rex2 Rac-GEF activity with IC50 of 4.5 uM (P-Rex1 DHPH Rac-GEF activity) in liposome-based GEF assay, inhibits P-Rex1 and P-Rex2 through their catalytic…
View activity & pricesDC60036SR-717 free acid
SR-717 is an agonist of stimulator of interferon genes STING for treating cancer. SR-717 demonstrates broad interspecies and interallelic specificity. SR-717 functions as a direct cyclic guanosine…
View activity & pricesDC4130Tirapazamine
Tirapazamine is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death.
View activity & pricesDC20201WAY-316606
WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. The affinity of WAY-316606 for sFRP-1 is determined using the FP binding assay with IC50 of 0.5 μM.
View activity & pricesDC67711UNC10225761A
UNC10225761A is a multi-kinase inhibitor, cocktail of UNC10225387B, UNC10225263A and UNC10225761A, promotes stem-cell-like chimeric antigen receptor T cells (CAR T cells).
View activity & pricesDC67665Allopole-A-octyl diamine derivative
Allopole-A-octyl diamine derivative is the prodrug of Allopole-A.
View activity & pricesDC67664Allopole prodrug moiety
Allopole prodrug moiety is the prodrug form of Allopole.
View activity & pricesDC46524HAIYPRH hydrochloride
HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier.
View activity & pricesDC20188Amodiaquine
Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.
View activity & pricesDC9812IWP-4
IWP-4 is a small molecule Wnt inhibitor with an IC50 of 25 nM.
View activity & pricesDC24202Ent-kaurene
Ent-kaurene is a tetracyclic diterpene consisting of ent-kaurane, where the 6-methyl group is replaced by methylene. It derives from a hydride of an ent-kaurane.
View activity & pricesDC60081IL-1R antagonist(TLR1)
TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses[1].
View activity & pricesDC12602LMT-28
LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6–induced luciferase activity), selectively inhibits IL-6–induced phosphorylation of STAT3, JAK2, and gp130;…
View activity & pricesDC23234Atorvastatin
A competitive inhibitor of HMG-CoA reductase that acts as a lipid-lowering agent for prevention of events associated with cardiovascular disease.DyslipidemiaApproved
View activity & pricesDC67846DBCO-PEG4-VC-PAB-MMAE
DBCO-PEG4-VC-PAB-MMAE consists a ADC linker (DBCO-PEG4-VC-PAB) and a tubulin polymerization inhibitor MMAE (HY-15162). DBCO-PEG4-VC-PAB-MMAE can be used in the synthesis of antibody-agent conjugates (ADCs). MMAE is a…
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