TRPM4 inhibitor 5 chemical structure
Chemical structureResearch use only
CAT. NO. DC21964Featured

TRPM4 inhibitor 5

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Product overview

Description & Application

TRPM4 inhibitor 5 is a potent and selective inhibitor of TRPM4 with IC50 of 1.5 uM (Na+ influx); selectively inhibits TRPM4 overexpressed in HEK293 cells (IC50=1.8 uM) using classical patch-clamp electrophysiology recordings, shows no significant effect on the TRPM5 current, as well as other TRP family members including TRPM7, TRPM8, TRPV1 and TRPV6.

ParameterValue
Chemical Name4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid
CAS No.351424-20-9
SynonymsTRPM4-IN-5;4-chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid;4-Chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid;CBMicro_024322;Oprea1_449670;GTPL10038;BDBM50526038;STK156559;compound 5 [PMID: 29579323];4-chloro-2-(2-(2-chlorophenoxy)acetamido) benzoic acid;4-chloro-2-{[(2-chlorophenoxy)acetyl]amino}benzoic acid;TRPM4-IN-1
FormulaC15H11Cl2NO4
M.Wt340.1581
SMILESClC1C([H])=C([H])C(C(=O)O[H])=C(C=1[H])N([H])C(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1Cl)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

TRPM4 inhibitor 5 is a potent and selective inhibitor of TRPM4 with IC50 of 1.5 uM (Na+ influx); selectively inhibits TRPM4 overexpressed in HEK293 cells (IC50=1.8 uM) using classical patch-clamp electrophysiology recordings, shows no significant effect on the TRPM5 current, as well as other TRP family members including TRPM7, TRPM8, TRPV1 and TRPV6.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

References 1. Ozhathil LC, et al. Br J Pharmacol. 2018 Jun;175(12):2504-2519. View Related Products by Target TRP Channel

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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