DC9542MPTP (hydrochloride)
MPTP hydrochloride is a brain penetrant dopamine neurotoxin, inducing Parkinson’s Disease.
View activity & pricesDC Chemicals · Research reagentsDC9542 
DC2105
DC10130
DC7049
DC22664
DC10518
DC7180
DC7461
DC11396
DC9241
DC8074
DC7938
DC8184
DC8091
DC7405
DCC0545
DC7752
DC5099
DC22612
DC7727
DCAPI1102
DC7173
DC8066
DC8001
DC5195
DC12703
DC7258
DC7647
DC5040
DCAPI1476
DC7832
DC7479
DC5007
DC6801
DC7094
DC7570
DC20275
DC7857
DC8229
DC7947
DC7853
DC8092
DCAPI1568
DC4221
DC10152
DC7923
DC12131
DC7750
Other Research Tools
1099 products · Page 3 of 23
All small molecule research tools
DC9542DC2105Lovastatin (MK-803)
Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.
View activity & pricesDC10130Glabridin
Glabridin is a natural isoflavan from Glycyrrhiza glabra, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor,…
View activity & pricesDC7049AdipoRon
AdipoRon is an orally active adiponectin receptor (AdipoR) agonist, binding to AdipoR1 and AdipoR2 with Kds of 1.8 and 3.1 μM, respectively.
View activity & pricesDC22664Fezolinetant
Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.
View activity & pricesDC10518KIN1148
KIN1148, a small-molecule IRF3 agonist, is a novel influenza vaccine adjuvant found to enhance flu vaccine efficacy.
View activity & pricesDC7180KN-93 Phosphate
KN-93 is a selective Ca2+/calmodulin-dependent protein kinase II inhibitor, which has been implicated in the regulation of smooth muscle contractility. CaM kinase II activation was inhibited by KN-93 pretreatment (IC50…
View activity & pricesDC7461Meisoindigo
Meisoindigo(Natura-α; N-Methylisoindigotin; Dian III), a derivative of Indigo naturalis, might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML).IC50 value:Target: apoptosis inducerin vitro:…
View activity & pricesDC11396DM1-SMe
DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. DM1-SMe can be readily conjugate to the SH group of an antibody to form…
View activity & pricesDC9241Tretinoin(Retinoic acid）
Tretinoin(Retinoic acid） is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for…
View activity & pricesDC8074MHY1485
MHY1485 is a cell-permeable mTOR activator. MHY1485 has an inhibitory effect on the autophagic process by inhibition of fusion between autophagosomes and lysosomes.
View activity & pricesDC7938SCR7 pyrazine
SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine is also a CRISPR/Cas9 enhancer which increases the efficiency of Cas9-mediated…
View activity & pricesDC8184Pilaralisib(XL-147; SAR245408)
Pilaralisib (XL147; SAR245408) is a potent and highly selective class I PI3Ks inhibitor with IC50s of 39 nM, 383 nM, 23 nM and 36 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ.
View activity & pricesDC8091Pyridostatin trifluoroacetate salt
Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM.
View activity & pricesDC7405DY131
DY131, a selective ERRγ agonist, could potentiate the ERRγ-induced growth inhibition in LNCaP- ERRγ and DU145- ERRγ cells in a dose-dependent manner compared with respective parental cells. DY131 inhibited the growth…
View activity & pricesDCC0545Alkyne-a-dsbso
Novel Enrichable and MS-Cleavable Cross-linker to Define Protein-Protein Interactions by Mass Spectrometry
View activity & pricesDC7752Vidofludimus(4SC-101; SC12267)
Vidofludimus(4SC-101; SC12267) is a novel immunosuppressive drug that inhibits DHODH; inhibits IL-17 secretion in vitro independently of effects on lymphocyte proliferation.
View activity & pricesDC5099Felbamate
Felbamate (FBM) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .Felbamate (marketed under the brand name Felbatol by MedPointe) is an…
View activity & pricesDC22612Afatinib
Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively.
View activity & pricesDC7727PH-797804
PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM; 4-fold more selective versus p38β and does not inhibit JNK2.
View activity & pricesDCAPI1102Telithromycin (Ketek)
For the detailed information of Telithromycin (Ketek), the solubility of Telithromycin (Ketek) in water, the solubility of Telithromycin (Ketek) in DMSO, the solubility of Telithromycin (Ketek) in PBS buffer, the…
View activity & pricesDC7173Irbesartan
Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.Target: Angiotensin ReceptorIrbesartan treatment markedly induces the expression of the adipogenic marker…
View activity & pricesDC8066Loxiglumide
Loxiglumide is a cholecystokinin (CCK-1) receptor antagonist.
View activity & pricesDC8001CPI 169 R-enantiomer
CPI-169, a representative compound from that effort, inhibits the catalytic activity of PRC2 with an IC50 of < 1nM, decreases cellular levels of H3K27me3 with an EC50 of 70 nM, and triggers cell cycle arrest and…
View activity & pricesDC5195Omecamtiv mecarbil (CK-1827452)
Omecamtiv mecarbil is a cardiac myosin activator.
View activity & pricesDC127035-Formyl-2-pyrimidinecarbonitrile
5-Formyl-2-pyrimidinecarbonitrile is a chemical intermidate..
View activity & pricesDC7258Bemcentinib（R428，BGB324)
Bemcentinib (R428) is a potent and selective inhibitor of Axl with an IC50 of 14 nM.
View activity & pricesDC7647Ximelagatran
Ximelagatran (H 376/95) is an orally active thrombin inhibitor that selectively and competitively inhibits both free and clot-bound thrombin. Ximelagatran is an anticoagulant agent with a rapid onset of anticoagulant…
View activity & pricesDC5040Oclacitinib maleate
Oclacitinib(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nM). IC50 value: 10 nM (JAK1) Target: JAKs in vitro: Oclacitinib…
View activity & pricesDCAPI1476Ertapenem Sodium
Ertapenem sodium is a new long-acting 1-β-methyl carbapenem antibiotic with a broad antibacterial spectrum including common aerobic and anaerobic bacteria and organisms with extended-spectrum β-lactamases.
View activity & pricesDC7832KB-R7943 mesylate
KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 µM.
View activity & pricesDC7479Tiplaxtinin(PAI-039)
Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 μM.
View activity & pricesDC5007pp1
PP1 is a potent, and Src family-selective tyrosine kinase inhibitor with IC50 of 5 and 6 nM for Lck and Fyn, respectively.
View activity & pricesDC6801Bindarit
Bindarit(AF-2838), a CCL2, CCL7 and CCL8 inhibitor, is an anti-inflammatory agent.
View activity & pricesDC7094Alpelisib(BYL-719)
Alpelisib (BYL-719) is a potent and selective PI3Kα inhibitor with an IC50 of 5 nM.
View activity & pricesDC7570Z-VAD(OMe)-FMK
Z-VAD(OMe)-FMK is a cell-permeable and irreversible pan-caspase inhibitor.
View activity & pricesDC20275LMP-744 hydrochloride
LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase (Top1) inhibitor with antitumor activity[1].
View activity & pricesDC7857GSK-LSD1
GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1).
View activity & pricesDC8229Vorapaxar Sulfate (SCH 530348)
Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate inhibits…
View activity & pricesDC7947Ledipasvir
Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively.
View activity & pricesDC7853GSK2801
GSK2801 is a potent, selective and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd=136 nM) and BAZ2B(Kd=257 nM) bromodomains.GSK2801 binds to BAZ2 bromodomains with dissociation constants (KD) of 136 and…
View activity & pricesDC8092L-755,507
L755507 is a potent, selective agonist of β3-AR with an IC50 of 35 nM.
View activity & pricesDCAPI1568Saxagliptin Hydrochloride
Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs.
View activity & pricesDC4221Teriflunomide(A-771726)
Teriflunomide is the active metabolite of leflunomide, an approved therapy for rheumatoid arthritis. It inhibits pyrimidine synthesis and therefore potently decreases T cell and B cell proliferation.
View activity & pricesDC10152Miquelianin (Quercetin 3-O-glucuronide)
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid.
View activity & pricesDC7923TAK-599 (ceftaroline fosamil)
TAK-599 (ceftaroline fosamil) is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).
View activity & pricesDC12131BF-227(E/Z)
BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils.
View activity & pricesDC7750UNC-0642
UNC0642 is a potent and selective G9a/GLP inhibitor, with an IC50 of less than 2.5 nM.
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