DC8495PTC-209 hydrobromide
PTC-209 hydrobromide is a specific BMI-1 inhibitor with IC50 of 0.5 μM in both GEMS reporter and ELISA assays.
View activity & pricesDC Chemicals · Research reagentsDC8495 
DC7904
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1099 products · Page 2 of 23
All small molecule research tools
DC8495DC7904CTX0294885
CTX-0294885 is a novel broad-spectrum kinase inhibitor. CTx-0294885 exhibits inhibitory activity against a broad range of kinases in vitro. Use of a quantitative proteomics approach confirmed the selectivity of…
View activity & pricesDC7477pac-1
PAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM.
View activity & pricesDC2012Bedaquiline (TMC207)
Bedaquiline is a diarylquinoline antibiotic that inhibits mycobacterial ATP synthase.
View activity & pricesDC7165NSI-189
NSI-189 is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine.
View activity & pricesDC8710Tranylcypromine HCl
Tranylcypromine HCl is an inhibitor of monoamine oxidase (MAO) and prostacyclin synthase, potently suppresses the enzymatic activity of Lysine-Specific Demethylase 1 (LSD1) (IC50 <2 μM for BHC110/LSD1).
View activity & pricesDC7437JIB-04
JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50s of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.
View activity & pricesDC7900AEGR-733(Lomitapide)
Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
View activity & pricesDC2005PTC124 (Ataluren)
Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.
View activity & pricesDC7066MEK162(Binimetinib)
Binimetinib (MEK162) is an oral and selective MEK1/2 inhibitor with an IC50 of 12 nM.
View activity & pricesDC9641NSC348884
NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.
View activity & pricesDC7443Kobe0065
Kobe0065 is a novel and effective inhibitor of Ras-Raf interaction, competitively inhibiting the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46±13 μM.
View activity & pricesDC7212NMS-873
NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with IC50 value of 30 nM.
View activity & pricesDC7996BAY 87-2243
BAY 87-2243 is a highly potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor.
View activity & pricesDC10844Aftin-4
Aftin-4 is an Amyloid-β42 (Aβ42) inducer.
View activity & pricesDC10201STK16-IN-1
STK16-IN-1 is a STK16 kinase inhibitor with an IC50 of 295 nM.
View activity & pricesDC7375BMS-303141
BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM.
View activity & pricesDC7319CCDC(TGR5-Receptor-Agonist)
TGR5 Receptor Agonist, a potent TGR5(GPCR19) agonist, showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5).
View activity & pricesDC5070IOX2
IOX2 is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM.
View activity & pricesDC7299SRPIN340
SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1.
View activity & pricesDC7523TTP22
TTP 22 is a potent CK2 inhibitor, with an IC50 of 100 nM and a Ki of 40 nM.
View activity & pricesDC26011GSK3145095
GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1].
View activity & pricesDC7734CZC24832
CZC24832 is a highly selective and potent PI3Kγ inhibitor (IC50=27 nM) with apparent dissociation constants (Kdapp) of 19 nM.
View activity & pricesDC5011UNC0631
UNC 0631 is a potent G9a inhibitor with IC50 value of 4 nM.UNC 0631, which had high in vitro potency versus G9a and improved lipophilicity, was highly potent (IC50 < 0.06 μM) in reducing H3K9me2 levels in MDA-MB-231…
View activity & pricesDC7239PluriSln 1(NSC 14613)
PluriSln 1 is an inhibitor of stearoyl-coA desaturase (SCD), and is a pluripotent cell-specific inhibitor.
View activity & pricesDCAPI1436Milbemycin oxime
Milbemycin oxime is a veterinary drug from the group of milbemycins, used as a broad spectrum antiparasitic.
View activity & pricesDC11412SR 0987
SR0987 is a RORγt agonist, with an EC50 of 800 nM.
View activity & pricesDC7586LDN-212854
LDN-212854 is a novel BMP inhibitor that exhibits substantially greater selectivity for BMP versus the TGF-β type I receptors; possesses a bias towards ALK2(IC50=1.3 nM) versus ALK1 and ALK3 compared to other…
View activity & pricesDC7454LH846
LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively.
View activity & pricesDC7896ELR-510444
ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell…
View activity & pricesDC7907UNC2250
UNC2250 is a phosphorylation of endogenous Mer inhibitor with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein.
View activity & pricesDC8244wp1066（STAT Inhibitor III）
WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3.
View activity & pricesDC8738Sal003
Sal003 is a potent cell-permeable analog of the eIF2α phosphatase inhibitor Salubrinal with enhanced aqueous solubility.IC50 value:Target: eIF2α phosphatase inhibitorSal003 has been shown to prevent dephosphorylation…
View activity & pricesDC7229PF-4708671
PF-4708671 is a potent cell-permeable S6K1 inhibitor with a Ki of 20 nM and IC50 of 160 nM.
View activity & pricesDC7975CP 640186
CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACCase) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431.
View activity & pricesDC10476NCGC00244536
NCGC00244536 is a potent KDM4B inhibitor with an IC50 of 10 nM.
View activity & pricesDC9795HA-15
HA15 is a molecule that targets specifically BiP/GRP78/HSPA5target: BiP, GRP78, HSPA5 [1]In vitro: HA15 induces ER stress leading to cancer cell death. kills cancer cells by targeting BiP to increase ER stress, leading…
View activity & pricesDC9240PS-47
PS-47 is available from DC Chemicals for laboratory research. Contact us for application-specific product information.
View activity & pricesDC12800BMS-927711(Rimegepant)
Rimegepant (BMS-927711) is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.
View activity & pricesDC8792Pirfenidone(AMR69)
Pirfenidone is a drug used for the treatment of idiopathic pulmonary fibrosis. It inhibits FGFR, EGFR, PDGFR, TGF-β, thereby slowing tumor cell proliferation.
View activity & pricesDC3153Ivabradine hydrochloride
Ivabradine (hydrochloride) is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent.
View activity & pricesDC5008PP2(AGL 1879)
PP2 is a reversible and ATP-competitive Src family kinases inhibitor with IC50s of 4 and 5 nM for Lck and Fyn, respectively.
View activity & pricesDC57110MAT2A inhibitor-2
MAT2A inhibitor-2 is a methionine adenosyltransferase 2A (MAT2A) inhibitor.
View activity & pricesDC1086GW-9508
GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, stimulates insulin secretion in a glucose-sensitive manner.IC50 value: 7.32 (pEC50) [1]Target:…
View activity & pricesDC7223Palomid 529 (P529)
Palomid 529 is a potent inhibitor of mTORC1 and mTORC2 complexes.
View activity & pricesDC7147GZD824
GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively. IC50 Value: 0.34/0.68 nM(Bce-Abl wt/T315I) [1]Target: Bcr-Abl in vitro: GZD824…
View activity & pricesDC7458LY2608204
LY2608204 is a activator of glucokinase (GK) with EC50 of 42 nM.IC 50 value: 42 nM (EC50)Target: glucokinasein vitro: LY2608204 activates glucokinase (GK) with EC50 of 42 nM at 10 mM glucose with a concentration…
View activity & pricesDC9505Pifithrin-α (hydrobromide)
Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis.
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