DC33090ONO-8130
ONO-8130 is an orally available EP1 receptor antagonist.
View activity & pricesDC Chemicals · Research reagentsDC33090 
DC57880
DC9970
DC26217
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Other Research Tools
1099 products · Page 14 of 23
All small molecule research tools
DC33090DC57880MRTX1133(MRTX-1133)
MRTX1133 is a noncovalent, potent, and selective KRAS G12D inhibitor. MRTX1133 optimally fills the switch II pocket and extends three substituents to favorably interact with the protein, resulting in an estimated KD…
View activity & pricesDC9970IDE-1
IDE1 is an inducer of definitive endoderm 1 (IDE1).
View activity & pricesDC26217Compstatin
Compstatinis is a 13-residue cyclic peptide, and a potent inhibitor of the complement system.
View activity & pricesDC20410Hydrazinocurcumin
Hydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity, inhibits STAT3 phosphorylation and downregulates…
View activity & pricesDC34373N2-OH-PhIP
N2-OH-PhIP is a PhIP metabolite.
View activity & pricesDC21895DOTA-ADIBO
DOTA-ADIBO is a Click Chemistry intermidate used for antibody-drug conjugates.
View activity & pricesDC65822Valemetostat tosylate
Valemetostat (DS-3201) tosylate, a first-in-class EZH1/2 dual inhibitor with IC50 values ＜10 nM. Valemetostat tosylate can be used for the research of relapsed/refractory peripheral T-cell lymphoma.
View activity & pricesDC60333BRD7586
BRD7586 is a cell-permeable small molecule inhibitor of SpCas9 with EC50 of 6.2 µM and 5.7 µM in the eGFP-disruption and HiBiT-knock-in assays, respectively. BRD7586 specifically engages SpCas9 but not Cas12a in cells…
View activity & pricesDC46910Sebetralstat
Sebetralstat is a plasma kallikrein inhibitor (WO2016083820). Sebetralstat can be used for the research of metabolic diseases.
View activity & pricesDC437692OH-BNPP1
2OH-BNPP1 is an inhibitor of BUB1 kinase, a Ser/Thr kinase, used for the treatment of cancer.
View activity & pricesDC60444FX-909
FX-909（FX 909） is a first-in-class inverse agonist of the peroxisome proliferator-activated receptor gamma (PPARG) lineage transcription factor with EC50 of 1 nM and shows >2000-fold selectivity for PPARG over…
View activity & pricesDC57076GPR65 agonist (BTB09089)
GPR65 agonist (BTB09089) is a novel GPR65 agonist.
View activity & pricesDC22223SB02024
SB02024 is a novel highly potent, selective, ATP competitive, orally active inhibitor of vacuolar protein sorting 34 (Vps34) with Kd of 1 nM, >1000 times selective towards other PI3K isoenzymes; SB02024 is also highly…
View activity & pricesDC39817LDC203974(IMT1B)
LDC203974(IMT1B) is a highly specific inhibitor of human mitochondrial RNA polymerase (POLRMT) with improved pharmacokinetic profiles than LDC195943(IMT1).
View activity & pricesDC23102Nalfurafine
Nalfurafine (TRK-820) is a potent selective and orally active G protein-biased kappa opioid receptor (KOR)-agonist with high translational potential[1]. Nalfurafine (TRK-820) enhances the therapeutic potential of…
View activity & pricesDC65657Palmitoyl hexapeptide-12
Palmitoyl hexapeptide-12 is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient.
View activity & pricesDC8445Onvansertib (NMS-P937)
NMS-1286937 is a potent, selective and orally available PLK1 inhibitor, with an IC50 of 2 nM.
View activity & pricesDC22619Rotigotine
A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM); has 10-fold selectivity for the D3 receptor over the D2, D4, and D5 receptors and 100-fold selectivity for the D3 receptor over the D1 receptor; behaves…
View activity & pricesDC20664AMG-548
AMG-548 is a potent, oral and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γand p38δ. AMG 548 is also extremely potent in the inhibition of…
View activity & pricesDC21259LY 3130481
LY3130481 (CERC611) is a potent, selective, noncompetitive TARP γ8-associated AMPA receptors with IC50 of 65.3 nM (GluA1/TARP γ-8), with no activity for γ-2 (cerebellum) or other TARP members; demonstrates fully…
View activity & pricesDC89083Pacritinib citrate
Pacritinib Citrate is the citrate salt form of pacritinib, an orally bioavailable inhibitor of Janus kinase 2 (JAK2).
View activity & pricesDC45790ErSO
ErSO is a selective anticipatory unfolded protein response (a-UPR) activator. ErSO acts through ERα to elicit strong and sustained cytotoxic activation of the a-UPR. ErSO can be used for the research of cancer.
View activity & pricesDC11283SBI993
SBI-993 is an analog of SBI-477 that shows improved potency and suitable pharmacokinetic properties for in vivo bioavailability
View activity & pricesDC67709UNC10225387B
UNC10225387B is a multi-kinase inhibitor, cocktail of UNC10225387B, UNC10225263A and UNC10225761A, promotes stem-cell-like chimeric antigen receptor T cells (CAR T cells).
View activity & pricesDC32524MTDIA
MTDIA, also known as MT-DADMe-ImmA, and Methylthio-DADMe-Immucillin A, is a MTAP inhibitor. Human 5'-methylthioadenosine phosphorylase (MTAP) is solely responsible for 5'-methylthioadenosine (MTA) metabolism to permit…
View activity & pricesDC20945DC_AC50
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance[1].
View activity & pricesDC48721Biotin-aniline
Biotin-aniline is a probe with substantially high reactivity towards RNA and DNA. Biotin-aniline emerges as more efficient probe for capturing subcellular transcriptome in living cells with high spatial specificity.
View activity & pricesDC31239NSC729477
Exherin, also known as ADH-1, is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin,…
View activity & pricesDC46193BRM/BRG1 ATP Inhibitor-1
BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4…
View activity & pricesDC38000Leupeptin
Leupeptin is a protease inhibitor, will strongly inhibit Trypsin, Papain, Plasmin, Thrombokinase, Kallikrein and Cathepsin B. The half-maximal inhibitory concentration ranges from 0.5 to 75 μg/ml, depending on the…
View activity & pricesDC65679BI-2493
BI-2493 is a structural analogue of BI-2865 and a highly selective pan-KRAS inhibitor. BI-2493 can attenuate tumor growth. BI-2493 can be used for cancer iseases research.
View activity & pricesDC65676Fenretinide Glucuronide Monosodium Salt
Fenretinide Glucuronide Monosodium Salt, is the metabolite of Fenretinide (F250000), which is a synthetic retinoid deriverative, substances related to vitamin A. They are also shown to be used for the treatment of…
View activity & pricesDC22826Suramin sodium salt
Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity; inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34; induces…
View activity & pricesDC23522Aplaviroc HCl
Aplaviroc, also known as AK-602; GW-873140; GW873140A; ONO-4128, is a CCR5 entry inhibitor for the potential treatment of HIV infection. Aplaviroc (GW873140) binds specifically to human cellular CC chemokine receptor 5…
View activity & pricesDC21570Azvudine
Azvudine (RO 0622) is a potent HCV NS5B RNA polymerase inhibitor, inhibits HCV replication in the replicon system with IC50 of 24 nM; inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or…
View activity & pricesDC21105H3B-8800
H3B-8800 is an orally available splicing modulator that targets spliceosome SF3b complex containing either WT or mutant SF3B1 (binding IC50 of 0.3-2 nM); demonstrates dose-dependent inhibition of both canonical…
View activity & pricesDC65502BI-2865
BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 blocked nucleotide exchange to prevent the activation of wild-type KRAS and a broad range of KRAS mutants, including G12A/C/D/F/V/S, G13C/D, V14I, L19F, Q22K,…
View activity & pricesDC21584MIN-101
MIN-101 (Roluperidone, CYR-101, MT-210) is a higly potent 5-HT2A and sigma 2 receptor antagonist, with no direct dopamine affinities, for treatment of negative symptoms in schizophrenia. Schizophrenia Phase 3 Clinical
View activity & pricesDC60219Camibirstat (FHD-286)
FHD-286 is a BRG1/BRM ATPase inhibitor for the treatment of BAF-related disorders such as acute myeloid leukemia.
View activity & pricesDC9717amyloid P-IN-1(GSK3039294)
pharmaceutical compositions comprising the same and the use of the same for treatment of diseases or disorders wherein depletion of serum amyloid P component (SAP) would be beneficial, including amyloidosis,…
View activity & pricesDC21821Perhexiline maleate
Perhexiline maleate is a potent carnitine palmitoyltransferase 1 (CPT 1) inhibitor with IC50s of 77 and 148 μM for rat heart and liver CPT 1, respectively.
View activity & pricesDC65521PTC-258 2HCl
PTC-258 2HCl is a specific and orally active splicing modulator of Elongator complex protein 1 gene (ELP1). PTC258 increases the expression of ELP1 in vitro and in vivo. PTC258 is well tolerated in mouse model.
View activity & pricesDC7410Erastin
Erastin is a ferroptosis activator.
View activity & pricesDC9651Ingenol 3-angelate
Ingenol 3-Angelate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has…
View activity & pricesDC47470SBP-3264
SBP-3264 (SBP3264) is a sepecific inhibitor of Hippo signaling pathway kinases STK3 and STK4 with low nanomolar potency. SBP-3264 specifically inhibited the Hippo signaling pathway in cultured mammalian cells and…
View activity & pricesDC60535NT-0796
NT-0796 is a Brain-Penetrant and Highly Potent. NLRP3 Inflammasome Inhibitor (IC50 = 0.32 nM) for Neuroinflammatory Disorders.
View activity & pricesDC60646GSDMD agonist DMB (C-185)
DMB(C-185) is a direct and selective GSDMD agonist that activates GSDMD pore formation and pyroptosis without cleaving GSDMD. DMB treatment synergizes with anti-PD-1 and does not alter circulating proinflammatory…
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