Camibirstat (FHD-286) chemical structure
Chemical structureResearch use only
CAT. NO. DC60219Featured

Camibirstat (FHD-286)

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Product overview

Description & Application

FHD-286 is a BRG1/BRM ATPase inhibitor for the treatment of BAF-related disorders such as acute myeloid leukemia.

ParameterValue
Chemical NameFHD-286
CAS No.2671128-05-3
SynonymsN-[(S)-1-[[4-[6-(cis-2,6-Dimethylmorpholino)pyridin-2-yl]thiazol-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]-1-(methylsulfonyl)-1H-pyrrole-3-carboxamide;FHD-286;SMARCA4/SMARCA2 ATPase Inhibitor FHD-286;1H-Pyrrole-3-carboxamide, N-((1S)-2-((4-(6-((2R,6S)-2,6-dimethyl-4-morpholinyl)-2-pyridinyl)-2-thiazolyl)amino)-1-(methoxymethyl)-2-oxoethyl)-1-(methylsulfonyl)-;GTPL11967;F78342;AKOS040759962;N-[(2S)-1-[[4-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-2-yl]-1,3-thiazol-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]-1-methylsulfonylpyrrole-3-carboxamide;HY-144835;N-((S)-1-(4-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-2-yl)thiazol-2-ylamino)-3-methoxy-1-oxopropan-2-yl)-1-(methylsulfonyl)-1H-pyrrole-3-carboxamide;FHD286;QHA5XLA4SA;camibirstat [INN];Camibirstat;NSC-840947;MS-30210;N-[(1S)-2-[[4-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-2-pyridinyl]-2-thiazolyl]amino]-1-(methoxymethyl)-2-oxoethyl]-1-(methylsulfonyl)-1H-pyrrole-3-carboxamide;CHEMBL5095181;2671128-05-3;FHD-286?;UNII-QHA5XLA4SA;1H-Pyrrole-3-carboxamide, N-[(1S)-2-[[4-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-pyridinyl]-2-thiazolyl]amino]-1-(methoxymethyl)-2-oxoethyl]-1-(methylsulfonyl)-;BRG1/BRM Inhibitor FHD-286;N-((2S)-1-((4-(6-((2S,6R)-2,6-dimethylmorpholin-4-yl)pyridin-2-yl)-1,3-thiazol-2-yl)amino)-3-methoxy-1-oxopropan-2-yl)-1-methylsulfonylpyrrole-3-carboxamide;NSC840947;EX-A6082;CS-0435579;FHD 286;SCHEMBL23673174;N-[(2S)-1-[[4-[6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]pyridin-2-yl]-1,3-thiazol-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]-1-methylsulfonylpyrrole-3-carboxamide
FormulaC24H30N6O6S2
M.Wt562.66
SMILES[C@H]1(C)O[C@@H](C)CN(C2=NC(C3N=C(NC(=O)[C@@H](NC(=O)C4=CN(S(=O)(C)=O)C=C4)COC)SC=3)=CC=C2)C1
Purity>98%
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.

Biological Activity

FHD-286 is a BRG1/BRM ATPase inhibitor for the treatment of BAF-related disorders such as acute myeloid leukemia.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Centore, Richard C. et al. Preparation of BRG1/BRM inhibitors for treating cancer. US20220079940 A1.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

Please store the product under the recommended conditions in the Certificate of Analysis.

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