Israpafant chemical structure
Chemical structureResearch use only
CAT. NO. DC22896Featured

Israpafant

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TotalUS$650
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Product overview

Description & Application

Israpafant (Y24180) is a specific antagonist of PAF receptor that inhibits PAF-induced rabbit platelet aggregation in vitro (IC50=3.84 nM), with little effect on adenosine diphosphate- or arachidonic acid-induced aggregation.

ParameterValue
Chemical Name4-(2-chlorophenyl)-2-(4-isobutylphenethyl)-6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
CAS No.117279-73-9
SynonymsY-24180;Y24180;Y 24180
FormulaC28H29ClN4S
M.Wt489.074
SMILESCC1C2=NN=C(N2C3=C(C=C(S3)CCC4=CC=C(C=C4)CC(C)C)C(=N1)C5=CC=CC=C5Cl)C
Purity>98%
Storage2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Biological Activity

Israpafant (Y24180) is a specific antagonist of PAF receptor that inhibits PAF-induced rabbit platelet aggregation in vitro (IC50=3.84 nM), with little effect on adenosine diphosphate- or arachidonic acid-induced aggregation.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

1. Takehara S, et al. Prostaglandins. 1990 Dec;40(6):571-83.

2. Kagoshima M, et al. Pharmacology. 1997 May;54(5):261-70.

3. Yamaguchi S, et al. Inflamm Res. 2000 Nov;49(11):584-90.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

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