DC Chemicals · Product datasheet

GSK-805 — Datasheet

CAT. NO. DC33598

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ParameterValue
Chemical NameN-[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)-benzeneacetamide
CAS No.1426802-50-7
SynonymsGSK805; GSK 805; GSK-805; ROR gamma-t-IN-1; RORγt Inverse Agonist II;
FormulaC23H18Cl2F3NO4S
M.Wt532.3552
SMILESO=C(NC1=CC(Cl)=C(C2=CC=CC=C2OC(F)(F)F)C(Cl)=C1)CC3=CC=C(S(=O)(CC)=O)C=C3
Purity98%

Biological Activity

GSK805, also known as ROR gamma-t-IN-1, is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA binding.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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