DC2047Crizotinib (PF-2341066)
Crizotinib is a potent inhibitor of c-Met and ALK with an IC50 of 11 nM and 24 nM in cell-based assays, respectively.
View activity & pricesDC Chemicals · Research reagentsDC2047 
DC7797
DCAPI1451
DC8730
DC8907
DC8322
DC10361
DC10266
DC7703
DC68007
DC9838
DC1012
DC10656
DC10558
DC82103
DC7688
DC7399
DC10752
DC9280
DC4143
DCAPI1501
DC8755
DC9535
DC10687
DC3139
DC7204
DC8925
DCAPI1329
DC4182
DC5908
DC7129
DC10545
DC12141
DC10065
DC8257
DCAPI1425
DC7745
DC6502
DC8398
DC10463
DC7093
DC8413
DC10885
DC20267
DC10019
DC7132
DC7481
Small Molecule Research Tools
2816 products · Page 47 of 59
Browse 372 research categories
DC2047DC7797ML365
ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3) with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiology assay).ML365 possesses more than 60-fold selectivity for…
View activity & pricesDCAPI1451Voriconazole
Voriconazole(UK-109496) is a second-generation triazole antifungal used to treat serious fungal infections.IC50 Value: Target: AntifungalVoriconazole displays potent activity against Candida, Cryptococcus and…
View activity & pricesDC8730Cambendazol
Cambendazol is an antihelmintic that, at a dose of 50 mg/kg/day in mice, eradicates S. ratti adult worms from intestine and S. stercoralis larva from muscle.It inhibits polymerization of microtubules isolated from…
View activity & pricesDC8907Lopinavir
Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM.Target: HIV proteaseLopinavir is a potent inhibitor of Rh123 efflux in Caco-2 monolayers with IC50 of 1.7 mM. Lopinavir exposure (72 hours) in LS 180V…
View activity & pricesDC8322Anacardic Acid
Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 and PCAF, with IC50s of ∼8.5 μM and ∼5 μM, respectively.
View activity & pricesDC10361Iberin
Iberin, a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. It inhibits cell survival with an IC50 of 2.3 μM in HL60 cell.
View activity & pricesDC10266Nandrolone decanoate
Nandrolone Decanoate is a mild form of an anabolic steroid.
View activity & pricesDC7703AEBSF-hydrochloride
AEBSF is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.
View activity & pricesDC68007Tri-GalNAc-β-Ala-PEG3-MAL
Tri-b-GalNAc-b-Ala-PEG3-MAL contains three terminal beta-N-acetylgalactosamine (GalNAc) sugars arranged in a trivalent configuration, facilitating high-affinity binding to the asialoglycoprotein receptor (ASGPR)…
View activity & pricesDC9838Alsterpaullone
Alsterpaullone (9-Nitropaullone;NSC 705701) is a potent cyclin-dependent kinases (CDK) inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively.…
View activity & pricesDC1012Macitentan (Actelion-1,ACT-064992)
Macitentan is an orally active, non-peptide endothelin receptor antagonist for the treatment of idiopathic pulmonary fibrosis and pulmonary arterial hypertension.
View activity & pricesDC10656(+)-JQ1 carboxylic acid
JQ-1 carboxylic acid is a highly potent, selective and cell-permeable BRD4 inhibitor with IC50s of 77 nM and 33 nM for BRD4(1) and BRD4(2), respectively.
View activity & pricesStructure information available on request
DC10138Auristatin E
Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates.
View activity & pricesDC10558ASP 7663
ASP7663 is an orally active and selective TRPA1 agonist. ASP7663 exerts both anti-constipation and anti-abdominal pain actions[1][2].
View activity & pricesDC82103Ensifentrine
Ensifentrine (RPL-554) is an inhaled first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively. Ensifentrine has bronchoprotective and anti-inflammatory…
View activity & pricesDC7688XMD-17-51
XMD-17-51 is a potent NUAK1-specific NUAK1 inhibitor
View activity & pricesDC7399Deferitrin
Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for…
View activity & pricesDC10752CNDAC HCl
CNDAC hydrochloride is a metabolite of the orally active agent sapacitabine, and a nucleoside analog[1].
View activity & pricesDC9280BMS-1 (PD1/PDL1 inhibitor 1)
PD-1/PD-L1 inhibitor C1 is a potent and selective small molecule inhibitor of the PD-1/PD-L1 protein/protein interactions with IC50 < 100 nM (PD-1/PD-L1 Homogenous Time-Resolved Fluorescence (HTRF) binding assay). It…
View activity & pricesDC4143Besifloxacin HCl
Besifloxacin hydrochloride is a fourth-generation fluoroquinolone antibiotic.
View activity & pricesDCAPI1501Lasofoxifene tartrate
Lasofoxifene Tartrate is a non-steroidal selective estrogen receptor modulator (SERM).
View activity & pricesDC8755WAY 100635 Hydrochloride
WAY 100635 Hydrochloride is available from DC Chemicals for laboratory research. Contact us for application-specific product information.
View activity & pricesDC9535Brivaracetam
Brivaracetam(UCB-34714) is a 4-substituted pyrrolidone butanamide as agent with significant antiepileptic activity; high affinity SV2A ligand and also shows an ability to inhibit Na+ channels. in vitro: Brivaracetam…
View activity & pricesDC10687Sematilide hydrochloride
Sematilide hydrochloride (CK-1752 hydrochloride) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III…
View activity & pricesDC3139Erlotinib hydrochloride
Erlotinib hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM.
View activity & pricesDC7204Ezatiostat(TER199; TLK199)
Ezatiostat is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).
View activity & pricesDC8925Atipamezole
Atipamezole is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM.
View activity & pricesDCAPI1329Argatroban
Argatroban is a direct, selective thrombin inhibitor.
View activity & pricesDC4182Temozolomide
Temozolomide (NSC 362856; CCRG 81045) is an oral DNA alkylating agent used to treat some brain cancers.
View activity & pricesDC5908Honokiol
Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the…
View activity & pricesDC7129GANT61(NSC 136476)
GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.
View activity & pricesDC10545AX-024 HCl
AX-024 hydrochloride is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A.
View activity & pricesDC12141E3 Ligase Ligand-Linker Conjugates 22
E3 Ligase Ligand-Linker Conjugates 22 incorporates an E3 ligase ligand and a linker, can be used for the treatment of EZH2-mediated cancer.
View activity & pricesDC10065Takeda-6d
Takeda-6d has potent inhibitory activity in both B-RAF with an IC50 of 7.0 nM and VEGFR2 with an IC50 of 2.2 nM.
View activity & pricesDC8257GNE 477
GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM)/mTOR(Ki=21 nM) inhibitor.
View activity & pricesDCAPI1425Anastrozole
Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM.
View activity & pricesDC7745Filorexant(mk-6096)
Filorexant (MK-6096) is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor(<3 nM in binding).
View activity & pricesDC6502cardamonin
Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM
View activity & pricesDC8398NPS-1034
NPS-1034 is a dual inhibitor of AXL and MET with IC50s of 10.3 and 48 nM, respectively.
View activity & pricesDC10463Repotrectinib(TPX-005)
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.
View activity & pricesDC7093BX912
BX-912 is a potent PDK1 inhibitors with an IC50 of 12 nM.
View activity & pricesDC8413STF-083010
STF-083010 is an Ire1 inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress.
View activity & pricesDC10885BCI-121
BCI-121 significantly inhibits SMYD3-substrate interaction and chromatin recruitment and is effective in reducing proliferation in various cancer cells types. BCI-121 significantly reduces proliferation of HT29 (by…
View activity & pricesDC20267Serotonin hydrochloride(5-HT)
Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
View activity & pricesDC10019VPS34 inhibitor 1 (Compound 19, PIK-III analogue)
VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM.
View activity & pricesDC7132GF 109203X
Bisindolylmaleimide I (GF109203X) is a highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor with a Ki of 14 nM.
View activity & pricesDC7481PHT427
PHT-247 is an inhibitor of the pleckstrin homology (PH) domain of Akt, and it is also an inhibitor of PDPK1 with Kis of 2.7 µM and 5.2 µM and for Akt and PDPK1, respectively.
View activity & prices