DC6901Daporinad(FK866,APO866)
FK866 is an effective inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) with an IC50 of 0.09 nM.
View activity & pricesDC Chemicals · Research reagentsDC6901 
DC4232
DC6301
DC10131
DC1099
DC8344
DC1071
DC5049
DC7868
DC8158
DC1069
DC9482
DC4177
Skin Cancer
13 products · Page 1 of 1
All small molecule research tools
DC6901DC4232Vismodegib (GDC-0449)
Vismodegib (GDC-0449) is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM. It also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively.
View activity & pricesDC6301PLX-4720
PLX-4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-RafV600E than wild-type B-Raf.
View activity & pricesDC10131BMS-986205(Linrodostat)
BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
View activity & pricesDC1099Trametinib
Trametinib is a potent MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Due to the poor solubility of Trametinib, Trametinib DMSO solvate (Cat. No.: HY-10999A) is recommeded.
View activity & pricesDC8344LY3009120
LY3009120 is a pan RAF inhibitor which inhibits BRAFV600E, BRAFWT and CRAFWT with IC50s of 5.8, 9.1 and 15 nM, respectively.
View activity & pricesDC1071Vemurafenib (PLX4032)
Vemurafenib is a novel and potent inhibitor of B-RAF kinase, with IC50s of 31 and 48 nM for RAFV600E and c-RAF-1, respectively.
View activity & pricesDC5049RAF265 (CHIR-265)
RAF265 is a potent RAF/VEGFR2 inhibitor.
View activity & pricesDC7868AS703026（Pimasertib）
Pimasertib (AS703026) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2, used for cancer treatment.
View activity & pricesDC8158Pexidartinib(PLX3397)
Pexidartinib (PLX-3397) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 13 nM, 27 nM, and 11 nM for CSF1R, c-Kit, and FLT3, respectively.
View activity & pricesDC1069AZD6244 (Selumetinib,ARRY-142886)
Selumetinib is a highly potent MEK inhibitor, with an IC50 of 14 nM against MEK1.
View activity & pricesDC948217-AAG
17-AAG is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90.
View activity & pricesDC4177Cobimetinib(GDC-0973; XL518)
Cobimetinib (GDC-0973, RG7420) is a potent, selective and oral MEK inhibitor with an IC50 of 4.2 nM for MEK1.
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