DC12285CID 1375606
CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27.
View activity & pricesDC Chemicals · Research reagentsDC12285 
DC10751
DC7081
DC9967
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Small Molecule Research Tools
2816 products · Page 29 of 59
Browse 372 research categories
DC12285DC10751M2698
M2698 (MSC2363318A) is an orally active, ATP competitive, selective p70S6K and Akt dual-inhibitor with IC50s of 1 nM for p70S6K, Akt1 and Akt3. M2698 can cross the blood-brain barrier and has anti-cancer activity[1].
View activity & pricesDC7081PF-04217903
PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM, susceptible to oncogenic mutations (no activity to Y1230C mutant).
View activity & pricesDC9967SQ22536
SQ22536 is an effective adenylate cyclase (AC) inhibitor.
View activity & pricesDC2056Droxidopa (L-DOPS,SM-5688)
Droxidopa(L-DOPS, SM5688) is a synthetic amino acid precursor which acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); capable of crossing the protective blood–brain…
View activity & pricesDC7222P005091(P5091)
P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with an EC50 of 4.2 μM.
View activity & pricesDC26008DSP2230
DSP-2230 is a selective Nav1.7/Nav1.8 blocker[1][2].
View activity & pricesDC8055Cyclo(-RGDfK)
Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Sequence: Cyclo(Arg-Gly-Asp-Phe-Lys).
View activity & pricesDC8029ANA-12
ANA-12 is a potent and selective TrkB antagonist with IC50s of 45.6 nM and 41.1 μM for the high and low affinity sites, respectively.
View activity & pricesDC21940Pizuglanstat
Pizuglanstat is a potent, selective prostaglandin D synthase inhibitor.
View activity & pricesDC11274AMPPD
AMPPD, 1,2 - dioxo-cyclohexane derivatives, is a new biochemistry ultrasensitive alkaline phosphatase substrate.
View activity & pricesDC10737Tropifexor (LJN452)
Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
View activity & pricesDC7992PX 12
PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1 (Trx-1); inhibits the growth of MCF-7 and HT-29 cells with IC50 values of 1.9 and 2.9 μM, respectively.
View activity & pricesDC21360MZ1
MZ 1 is a BRD4 protein degrader based on PROTAC technology.
View activity & pricesDC74298BC18630
BC18630 (BC 18630) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 39 nM in cell-based assays.
View activity & pricesDC12522MKK7-COV-3
MKK7-COV-3 (MKK7 Covalen inhibitor 3) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 5 nM, displays >1,000-fold selectivity over MKK4 (IC50=7.81 uM), shows EC50 of 1.3 uM for reduction of p-JNK…
View activity & pricesDC7836Doramapimod (BIRB-796)
Doramapimod (BIRB 796) is a highly potent p38 MAPK inhibitor with an IC50 of 4 nM. It also inhibits B-Raf with an IC50 of 83 nM.
View activity & pricesDC7279SB-590885
SB-590885 is a potent B-Raf inhibitor with Ki of 0.16 nM, and has 11-fold greater selectivity for B-Raf over c-Raf, without inhibition to other human kinases.
View activity & pricesDC23204WZ8040
WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).WZ8040 is 30- to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against…
View activity & pricesDC11141ME0328
ME0328 is a potent and selective ARTD3/PARP3 inhibitor with an IC50 of 0.89±0.28 μM.
View activity & pricesDC7572AZD1981
AZD1981 is a potent and selective CRTh2 antagonist; displaces radio-labelled PGD2 from human recombinant DP2 with high potency (pIC50 = 8.4).
View activity & pricesDC8126CALCIUM IONOPHORE II
N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide (Calcium ionophore II) is a lipophilic ionophore that can be used in preparing calcium ion-selective electrode[1].
View activity & pricesDC9874ML-348(ML348)
ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM), Exhibits 14-fold selectivity for LYPLA1 over LYPLA2, Also selective over a panel of ~30 other serine hydrolases.target: LYPLA1…
View activity & pricesDC11208TAK-071
TAK-071 is a novel muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM[1].
View activity & pricesDC27035EIDD-2801(Molnupiravir)
EIDD-2801 is an orally bioavailable isopropylester prodrug of the ribonucleoside analog EIDD-1931. EIDD-2801 shows anti-influenza virus and coronaviruses activities. EIDD-2801 has the potential for seasonal and…
View activity & pricesDC9690Sinogliatin (HMS5552, RO5305552)
Sinogliatin (HMS5552, RO5305552) is a mall molecule glucokinase (GCK; GK) activator.
View activity & pricesDC8333SC-79
SC79 is a selective and cell-permeable Akt activator which activates Akt phosphorylation and inhibits Akt membrane translocation.
View activity & pricesDC7552PTC-028
PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. Depletion of BMI-1 by PTC-028 induces…
View activity & pricesDC26147DANUGLIPRON（PF-06882961）
PF-06882961 is a potent, orally bioavailable agonist of the glucagon-like peptide-1 receptor (GLP-1R)
View activity & pricesDC23207JNJ-17203212
JNJ-17203212 is a novel and selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1.
View activity & pricesDC7389CP-673451
CP-673451 is a potent and selective inhibitor of PDGFR with IC50s of 10 and 1 nM for PDGFRα and PDGFRβ, respectively.
View activity & pricesDC12541iGOT1-01
iGOT1-01 is a small molecule inhibitor of aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1 (GOT1)) with IC50 of 11.3 uM.
View activity & pricesDC12542GOT1 inhibitor 2c
GOT1 inhibitor 2c is a first-in-class, non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with IC50 of 8.2 uM.
View activity & pricesDC8116Tosedostat (CHR2797)
Tosedostat is an aminopeptidase inhibitor.
View activity & pricesDC8749Plinabulin
Plinabulin (NPI-2358) is a vascular disrupting agents (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells.
View activity & pricesDC7103LY2603618(IC-83)
LY2603618 is a potent and selective inhibitor of Chk1 with an IC50 of 7 nM.
View activity & pricesDC5078Tivozanib(AV-951)
Tivozanib (AV-951; KRN951) is a highly potent and selective VEGFR 1/2/3 inhibitor with IC50s of 0.21, 0.16, and 0.24 nM in cell assay, respectively.
View activity & pricesDC7993Prexasertib (LY2606368) 2HCl
Prexasertib dihydrochloride (LY2606368 dihydrochloride) is a potent and selective ATP competitive inhibitor of the Chk1 protein kinase, with IC50s of <1 nM and 8 nM for CHK1 and CHK2, respectively, and a Ki of 0.9 nM…
View activity & pricesDC7792G-749
G-749 is a novel FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants with IC50s of 0.4/0.6/3.5/7.5 nM for Wt Flt3/D835Y/MV4-11/Molm-14 respectively.G-749 showed potent and…
View activity & pricesDC8094Ys-49
YS 49 inhibits Ang II-stimulated proliferation of VSMCs via induction of HO-1.YS-49 is a novel positive inotropic isoquinoline compound. YS-49 has potential as a therapeutic strategy for the pathogenesis of Ang…
View activity & pricesDC7530Voreloxin
Voreloxin is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.
View activity & pricesDC12370YF2
YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows…
View activity & pricesDC12178Pemigatinib
Pemigatinib is a selective FGFR inhibitor in development for the treatment of patients with cholangiocarcinoma.
View activity & pricesDC11571E3 Ligase Ligand 3
An E3 ligase ligand for PROTAC.
View activity & pricesDC31035Hydroxy dabrafenib
Hydroxy-dabrafenib is one of the three major metabolites of dabrafenib.
View activity & pricesDC21518PLX5622
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor, for extended and specific microglial elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties…
View activity & pricesDC11450Selpercatinib(LOXO-292)
Selpercatinib is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 163, has an IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M) , and RET (G810R), respectively[1].…
View activity & pricesDC7532Walrycin-B
Walrycin B is a novel antibacterial compound specifically targeting the essential WalR response regulator.Walrycin B is known as an analog of toxoflavin (a phytotoxin from Burkholderia glumae), which has been shown to…
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