DC7060AZD1152
AZD1152 is a pro-drug of Barasertib-hQPA, which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.
View activity & pricesDC Chemicals · Research reagentsDC7060 
DC4119
DC4174
DC1025
DC7303
DC7187
DC2010
DC5159
DC10648
DC7183
DC7027
DC1106
DC5154
DC7153
DC7927
DC8481
DC5147
DC7978
DC5072
DC5068
DC5197
DC7297
DC1027
DC7111
DC9701
DC5089
DC5024
DC8374
DC7475
DC8522
DC2070
DC5027
DC2096
DC10647
DC2018
DC9660
DC7019
DC8252
DC10439
DC5194
DC8377
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DC8840
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DC4125
DC8342
DC4157
DC5086
Blood Cancer
91 products · Page 1 of 2
All small molecule research tools
DC7060DC4119YM155
YM-155 is a survivin inhibitor with an IC50 of 0.54 nM.
View activity & pricesDC4174NVP-AEW541
NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 0.15 μM, also inhibits InsR, with IC50 of 0.14 μM.
View activity & pricesDC1025AT7519 HCL
AT7519 Hydrochloride is a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.
View activity & pricesDC7303NVP-TAE684
NVP-TAE 684 is a highly potent and selective ALK inhibitor, which blocks the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM.
View activity & pricesDC7187Volasertib(BI6727)
Volasertib is a highly potent Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0.87 nM, as well as the two closely related kinases PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively.
View activity & pricesDC2010Oprozomib (ONX-0912)
Oprozomib (ONX 0912; PR047) is an orally bioavailable inhibitor for CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM.The anti-MM activity of Oprozomib is associated with activation of caspase-8,…
View activity & pricesDC5159CP-868596 (Crenolanib)
Crenolanib is a potent and selective inhibitor of wild-type and mutant isoforms of the class III receptor tyrosine kinases FLT3 and PDGFRα/β with Kds of 2.1 nM/3.2 nM, 0.74 nM, respectively.
View activity & pricesDC10648CA4948-Analog
CA-4948 is a selective and potent IRAK4 inhibitor.
View activity & pricesDC7183Panobinostat(LBH589)
Panobinostat is a non-selective histone deacetylase (HDAC) inhibitor.
View activity & pricesDC7027Glasdegib(PF-04449913)
Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM.
View activity & pricesDC1106PCI-32765 (Ibrutinib)
Ibrutinib (PCI-32765) is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM.
View activity & pricesDC5154BKM120 (NVP-BKM120, Buparlisib)
NVP-BKM120 is a pan-class I PI3K inhibitor, with IC50s of 52, 166, 116 and 262 nM for p110α, p110β, p110δ and p110γ, respectively.
View activity & pricesDC7153CX6258
CX-6258 is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity.
View activity & pricesDC7927EPZ011989
EPZ011989 is a potent, selective orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 wt and EZH2 Y646; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.IC50 value: < 3 nM ( Ki for wt…
View activity & pricesDC8481Delanzomib(CEP-18770)
Delanzomib(CEP-18770) is a novel orally-active inhibitor of the chymotrypsin-like activity of the proteasome that down-modulates the nuclear factor-kappaB (NF-kappaB) activity.
View activity & pricesDC5147Molibresib(I-BET-762）
GSK 525762A is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.
View activity & pricesDC7978Tucidinostat(Chidamide)
Chidamide is a synthetic benzamide-type HDAC inhibitor, inhibits HDAC1, HDAC2, HDAC3 and HDAC10 with IC50s of 95, 160, 67 and 78 nM, respectively.
View activity & pricesDC5072Duvelisib (IPI-145, INK1197)
Duvelisib is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively.
View activity & pricesDC5068Idelalisib (CAL-101,GS-1101)
Idelalisib (CAL-101) is a highly selective and potent p110δ inhibitor with an IC50 of 2.5 nM, showing 40- to 300-fold selectivity for p110δ over other PI3K class I enzymes.
View activity & pricesDC5197Quizartinib (AC220)
Quizartinib (AC220) is a potent Flt3 tyrosine kinase inhibitor with a Kd of 1.6±0.7 nM.
View activity & pricesDC7297SNS-032(BMS-387032)
SNS-032 (BMS-387032) is a selective inhibitor of?CDK2, CDK7, and CDK9 with?IC50s?of 38 nM, 62 nM and 4 nM, respectively.
View activity & pricesDC1027Bortezomib (Velcade,MG-341,PS-341)
Bortezomib (PS-341) is a potent 20S proteasome inhibitor with a Ki of 0.6 nM.
View activity & pricesDC7111CX-4945 (Silmitasertib)
CX-4945 is a potent, selective and oral casein kinase 2 (CK2) inhibitor with a Ki of 0.38 nM.
View activity & pricesDC9701Tipifarnib
Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, and the anti-proliferative effects are most prominent in H-ras or N-ras mutant cells.
View activity & pricesDC5089Ixazomib Citrate (MLN-9708)
Ixazomib citrate (MLN9708) is a reversible inhibitor of the chymotrypsin-like proteolytic β5 site of the 20S proteasome with an IC50 of 3.4 nM and a Ki of 0.93 nM.
View activity & pricesDC5024MK-8776 (SCH 900776)
SCH900776 is a potent, selective and oral inhibitor of checkpoint kinase1 (Chk1) with an IC50 of 3 nM. It shows 50- and 500-fold selectivity over CDK2 andChk2, respectively.
View activity & pricesDC8374Enasidenib ( AG-221)
Enasidenib is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K, respectively.
View activity & pricesDC7475OTSSP167 HCl
OTSSP167 (hydrochloride) is a highly potent MELK inhibitor with IC50 value of 0.41 nM.
View activity & pricesDC8522KW-2449
KW-2449 is a multi-targeted kinase inhibitor of FLT3, ABL, ABLT315I and Aurora kinase with IC50s of 6.6, 14, 4 and 48 nM, respectively.
View activity & pricesDC2070GSK690693
GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2/13/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes.
View activity & pricesDC5027ABC294640（Opaganib）
Opaganib (ABC294640) is a selective, competitive sphingosine kinase 2 (SK2) inhibitor with Ki of 9.8 μM.
View activity & pricesDC2096AG490
AG-490 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
View activity & pricesDC10647EPZ015938(pemrametostat)
GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM.
View activity & pricesDC2018LY335979 (Zosuquidar 3HCl)
Zosuquidar trihydrochloride is an inhibitor of P-glycoprotein with a Ki value of 59 nM.
View activity & pricesDC9660Acalabrutinib(ACP196)
Acalabrutinib is a novel, potent, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM in in vitro assay.
View activity & pricesDC7019LY-2874455
LY2874455 is a pan-FGFR inhibitor with IC50s of 2.8, 2.6, 6.4, 6 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively.
View activity & pricesDC8252Vorinostat (SAHA)
Vorinostat is a potent and orally available inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC7 (Class II) and HDAC11 (Class IV ), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively.
View activity & pricesDC10439Vorasidenib (AG881)
Vorasidenib is a pan isocitrate dehydrogenase (IDH) inhibitor.
View activity & pricesDC5194NVP-BGJ398(Infigratinib)
Infigratinib (BGJ-398) is a potent inhibitor of the FGFR family with IC50s of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.
View activity & pricesDC8377CC-115
CC-115 is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.
View activity & pricesDC7196MGCD0103 (Mocetinostat)
Mocetinostat (MGCD0103) is a potent, orally active and isotype-selective HDAC (Class I/IV) inhibitor with IC50s of 0.15, 0.29, 1.66 and 0.59 μM for HDAC1, HDAC2, HDAC3 and HDAC11, respectively. Mocetinostat shows no…
View activity & pricesDC8840CB-5083
CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . CB-5083 causes rapid and…
View activity & pricesDC8051AG-120 (Ivosidenib)
Ivosidenib (AG-120) is a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor with an IC50 of 12 nM for mouse IDH1R132H.
View activity & pricesDC4125PHA-739358 (danusertib)
Description of Danusertib: Danusertib is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Aurora kinase inhibitor PHA-739358 binds to and inhibits the Aurora kinases, which may result…
View activity & pricesDC8342EW-7197
Vactosertib (EW-7197) is an ATP-competitive inhibitor of ALK5 with an IC50 of 12.9 nM. It also inhibits ALK2 and ALK4 at nanomolar concentrations.
View activity & pricesDC4157Dovitinib (TKI258, CHIR258)
Dovitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively.
View activity & pricesDC5086Ixazomib(MLN2238)
Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC50 of 3.4 nM (Ki of 0.93 nM).
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