CA4948-Analog chemical structure
Chemical structureResearch use only
CAT. NO. DC10648Featured

CA4948-Analog

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TotalUS$750
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Product overview

Description & Application

CA-4948 is a selective and potent IRAK4 inhibitor.

ParameterValue
Chemical NameN-(1-(6'-amino-[2,3'-bipyridin]-5-yl)vinyl)-2-morpholinooxazolo[4,5-c]pyridin-6-amine
CAS No.1801343-74-7
SynonymsCA-4948; CA 4948; CA4948
FormulaC21H19N7O3
M.Wt417.42
SMILESO=C(C1=CC=CC(C2=CC=C(N)N=C2)=N1)NC3=CN=C4C(OC(N5CCOCC5)=N4)=C3
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

CA-4948 is a selective and potent IRAK4 inhibitor.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

CA-4948 is a selective and potent IRAK4 inhibitor which can be used as a therapeutic agent for hematological cancers with dysregulated TLR/MYD88/IRAK4 signaling. CA-4948 exhibits favorable DMPK properties, oral bioavailability, and is well tolerated in mice. Furthermore, CA-4948 is previously shown to exhibit dose-dependent efficacy in ABC-DLBCL MYD88-L265P xenograft tumor models[1].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

View online datasheetRequest COA / MSDS

Refer to the certificate supplied with your lot for batch-specific release results.

Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

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