DC4127ABT-263 (Navitoclax)
Navitoclax (ABT-263) is a potent and oral Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM.
View activity & pricesDC Chemicals · Research reagentsDC4127 
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DC7070
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DC8116
DC5057
DC7359
DC12163
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Blood Cancer
91 products · Page 2 of 2
All small molecule research tools
DC4127DC7634PKC-412 (Midostaurin)
Midostaurin (CGP41231; PKC412) is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 ranging from 16-500 nM.
View activity & pricesDC10047PIM-447 dihydrochloride
PIM447 is a pan-PIM kinase ihibitor with Kis of 6, 18, 9 nM for PIM1, PIM2 and PIM3, respectively.
View activity & pricesDC10485GDC0575（ARRY-575，RG7441）
GDC-0575 (ARRY-575, RG7741) is a highly-selective oral small-molecule Chk1 inhibitor with an IC50 of 1.2 nM.
View activity & pricesDC8760Acalisib
Acalisib is a potent and selective PI3Kδ inhibitor with an IC50 of 12.7 nM.
View activity & pricesDC9799CNDAC
CNDAC is the active component of sapacitabine. Sapacitabine is an oral nucleoside analog prodrug that acts through a dual mechanism. The compound interferes with DNA synthesis by causing single-strand DNA breaks and…
View activity & pricesDC2013Bafetinib (INNO-406)
Bafetinib is a Lyn and Bcr-Abl tyrosine kinase inhibitor with potential antineoplastic activity.
View activity & pricesDC7070AT9283
AT9283 is a multitargeted kinase inhibitor which potently inhibits aurora kinase A/B, JAK2/3 (IC50=1.2 nM, 1.1 nM).
View activity & pricesDC7067KPT-330(Selinexor)
KPT-330, analog of KPT-185, is an orally bioavailable selective CRM1 inhibitor.IC50 value: Target: CRM1in vitro: As the clinical candidate analog of KPT-185, KPT-330 exhibits similar effects on the viability of T-ALL…
View activity & pricesDC1006OSI-027
OSI-027 is an ATP-competitive mTOR kinase activity inhibitor with an IC50 of 4 nM. OSI-027 targets both mTORC1 and mTORC2 with IC50s of 22 nM and 65 nM, respectively.
View activity & pricesDC7114Dinaciclib (SCH727965)
Dinaciclib is a potent inhibitor of CDK, with IC50s of 1, 1, 3, and 4 nM for CDK2, CDK5, CDK1, and CDK9, respectively.
View activity & pricesDC8275Apilimod
Apilimod is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively.
View activity & pricesDC8780Flavopiridol Hydrochloride
Flavopiridol Hydrochloride is a broad inhibitor of CDK, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively.
View activity & pricesDC8116Tosedostat (CHR2797)
Tosedostat is an aminopeptidase inhibitor.
View activity & pricesDC5057Enzastaurin (LY317615)
Enzastaurin is a potent and selective PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε.
View activity & pricesDC7359Asp-3026
ASP3026 is a novel and selective inhibitor for ALK (anaplastic lymphoma kinase) with IC50 of 3.5 nM.
View activity & pricesDC12163S55746 (BLC201)
S55746 is an orally active, selective and potent BCL-2 inhibitor, with a Ki of 1.3 nM.
View activity & pricesDC8358ONO-4059(Tirabrutinib)
Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM.
View activity & pricesDC7280Pracinostat(SB939)
Pracinostat is a potent histone deacetylase (HDAC) inhibitor, with IC50s of 40-140 nM, used for cancer research.
View activity & pricesDC9972ARQ-092(Miransertib)
ARQ-092 is an orally bioavailable, selective, and potent allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.
View activity & pricesDC7506Sotrastaurin
Sotrastaurin is a potent pan-PKC inhibitor, with Kis of 0.22 nM, 0.64nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively.
View activity & pricesDC10975ARQ-531
ARQ 531 is a reversible non-covalent inhibitor of Bruton’s Tyrosine Kinase (BTK), with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.
View activity & pricesDC8164Gilteritinib(ASP2215)
Gilteritinib is a potent FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively.
View activity & pricesDC12378Itacitinib(INCB039110)
Itacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis.
View activity & pricesDC7238Gedatolisib(PKI-587)
Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively. PKI-587 is equally effective in both complexes of mTOR, mTORC1 and mTORC2.
View activity & pricesDC3130ICG-001
ICG-001 is an inhibitor of β-catenin/TCF mediated transcription. It works by specifically binding to cyclic AMP response element-binding protein with an IC50 of 3 μM.
View activity & pricesDC5055Plerixafor (AMD3100)
Plerixafor is a selective CXCR4 antagonist with an IC50 of 44 nM.
View activity & pricesDC7367AZ-960
AZ960 also inhibits many kinases less than 50% at a concentration of 0.1 μM such as JAK3 (IC50=9 nM), TrkA, Aurora, and ARK5. In cells, AZ 960 inhibits the phosphorylation of STAT5 in TEL-JAK2 cells with an average…
View activity & pricesDC7665Gandotinib(LY2784544)
Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM. Gandotinib (LY2784544) also inhibits FLT3, FLT4, FGFR2, TYK2, and TRKB with IC50 of 4, 25, 32, 44, and 95 nM.
View activity & pricesDC1002Carfilzomib (PR-171)
Carfilzomib is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells.
View activity & pricesDC11387Erdafitinib
Erdafitinib (JNJ-42756493) is a potent and orally available FGFR family inhibitor; inhibits FGFR1/2/3/4 with IC50s of 1.2, 2.5, 3.0 and 5.7 nM, respectively.
View activity & pricesDC7486PX-478 2HCL
PX-478 is an antitumor inhibitor of hypoxia-inducible factor-1α (HIF-1α).
View activity & pricesStructure information available on request
DC7083Bi 2536
BI 2536 is a dual PLK1 and BRD4 inhibitor with IC50s of 0.83 and 25 nM, respectively.
View activity & pricesStructure information available on request
DC10448Belizatinib(TSR-011)
Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.
View activity & pricesDC7664Quarfloxin (CX-3543)
Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity.
View activity & pricesDC9755eFT508(Tomivosertib)
eFT508 is a potent, highly selective, and orally bioavailable MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms.
View activity & pricesDC10423Motixafortide(BKT140)
BKT140 4-fluorobenzoyl is a novel CXCR4 antagonist with an IC50 vakue of ～1 nM. Sequence: 4F-Benzoyl-Arg-Arg-{2-Naph-Ala}-Cys-Tyr-{Cit}-Lys-Lys-Pro-Tyr-Arg-{Cit}-Cys-Arg-NH2(Disulfide bridge: Cys4-Cys13).
View activity & pricesDC3144Nilotinib
Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
View activity & pricesDC9837Larotrectinib (LOXO-101 sulfate)
Larotrectinib (LOXO-101) sulfate is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms…
View activity & pricesDC2100Dasatinib (BMS-354825)
Description of Dasatinib: Dasatinib is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases.…
View activity & pricesDC10526Elimusertib hydrochloride (BAY 1895344 hydrochloride)
BAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity[1].
View activity & pricesDC8541Iadademstat dihydrochloride (ORY-1001 dihydrochloride)
ORY-1001 dihydrochloride (RG-6016, Ladademstat) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM, displays high selectivity for KDM1A over other FAD-containing…
View activity & pricesDC7265Rigosertib sodium
Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM; shows 30-fold greater selectivity against PLK2 and no activity to PLK3.
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