Structure information available on request
Chemical structureResearch use only
CAT. NO. DC10448Featured

Belizatinib(TSR-011)

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TotalUS$600
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Product overview

Description & Application

Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.

ParameterValue
Chemical NameBelizatinib
CAS No.1357920-84-3
SynonymsBelizatinib;TSR-011;Belizatinib (TSR011);Z8A6022P3J;Belizatinib [INN];4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)benzamide;4-Fluoro-N-{(2e)-6-{[4-(2-Hydroxypropan-2-Yl)piperidin-1-Yl]methyl}-1-[cis-4-(Propan-2-Ylcarbamoyl)cyclohexyl]-1,3-Dihydro-2h-Benzimidazol-2-Ylidene}benzamide;4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-
FormulaC33H44FN5O3
M.Wt577.7326
SMILESFC1C([H])=C([H])C(=C([H])C=1[H])C(N([H])C1=NC2C([H])=C([H])C(=C([H])C=2N1C1([H])C([H])([H])C([H])([H])C([H])(C(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=O)C([H])([H])C1([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(C([H])([H])[H])(C([H])([H])[H])O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.

In Vitro

TSR-011 has antitumour activity in the clinical trials.

In Vivo

TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models[1].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

View online datasheetRequest COA / MSDS

Refer to the certificate supplied with your lot for batch-specific release results.

Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

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